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Under what conditions do South American states create regional institutions that consolidate or undermine the liberal international order (LIO)? To address this question, we compare two cases of contestation of the LIO through counter-institutionalization in the domains of migration and election monitoring, both of which are closely related to the LIO’s core political principles. We argue that the variation in the effects of counter-institutionalization—LIO-consolidating in the case of migration and LIO-undermining in the case of election monitoring—results from the interaction of two explanatory factors: the source of dissatisfaction with the LIO’s norms and institutions in a specific domain, and the preferences of the state that exercises regional leadership in support of counter-institutionalization. The article sheds light on the coexistence of liberal and illiberal tendencies in South America’s regionalism and contributes to the debate on the determinants and effects of contestations of the LIO in the Global South.
Numerous studies have explored the relationship between brain aging and major depressive disorder (MDD) and attempted to explain the phenomenon of faster brain aging in patients with MDD from multiple perspectives. However, a major challenge in this field is elucidating the ontological basis of these changes. Here, we aimed to explore the relationship between brain structural changes in MDD-related brain aging and neurotransmitter expression levels and transcriptomics.
Methods
Imaging data from 670 Japanese participants (MDD: health controls = 233:437) and the support vector regression model were utilized to predict and compare brain age between MDD patients and healthy controls. A map of differences in cortical thickness was generated, furthermore, spatial correlation analysis with neurotransmitters and correlation analysis with gene expression were performed.
Results
The degree of brain aging was found to be significantly higher in patients with MDD. Moreover, significant cortical thinning was observed in the left ventral area, and premotor eye field in patients with MDD. A significant correlation was observed between MDD-related cortical thinning and neurotransmitter receptors/transporters, including dopaminergic, serotonergic, and glutamatergic systems. Enriched Gene Ontology terms, including protein binding, plasma membrane, and protein processing, contribute to MDD-related cortical thinning.
Conclusions
The findings of this study provide further evidence that patients with MDD experience more severe brain aging, deepening our understanding of the underlying neural mechanisms and genetic basis of the brain changes involved. Additionally, these findings hold promise for the development of interventions aimed at preventing further deterioration in MDD-related brain aging, thus offering potential therapeutic avenues.
Investigating speech fluency has, for a long time, been at the core of second language (L2) studies, as fluency is believed to epitomise successful acquisition of L2, characterise effective communication, elucidate the complex process of acquisition, and predict L2 speakers' proficiency. The significance attributed to fluency in these areas explicates the research attention paid to it over the past decades. An important area of development in this regard is L2 assessment in which fluency is recognised as a key underlying construct of spoken language ability by international language tests (e.g., IELTS, TEEP, APTIS) and language benchmarks (e.g., CEFR). Many high-stakes tests of English and other languages include fluency in their rating scales, with the earliest on record tracing back to the 1930s – the College Board's English Competence Examination (1930) in America. Including fluency as a fundamental aspect of speaking ability in the rating scales, rating descriptors, and rater training materials, either as an independent criterion or combined with others (e.g., delivery), has become common practice in language testing over the past decades. What has made assessment of fluency even more appealing to researchers and test providers in recent years is the objectivity and reliability of its measurement and its compatibility with the technological developments in automated assessment of speaking. Fluency is now largely recognised as a construct that can be efficiently and reliably assessed in automated assessment of spoken language ability and used to predict proficiency (de Jong, 2018*; Ginther et al., 2010*; Kang & Johnson, 2021*; Tavakoli et al., 2023).
We seek to clarify how changes in the prevalence of drug use disorder (DUD) in Sweden in the 1950–1990 birth cohort impact the aggregation and co-aggregation in siblings of DUD and alcohol use disorder (AUD).
Methods
We examined risk for DUD and AUD in siblings of 102,624 DUD cases and matched control probands and 123,837 AUD case and matched control probands identified using Swedish registries. Flexible parametric survival models assessed the difference in disorder risk in siblings of case versus control probands.
Results
Over birthyears 1950–1990, rates of DUD increased substantially in the Swedish population. In siblings of DUD cases versus controls, the risk for DUD increased dramatically starting in birthyear 1965 while their risk for AUD fell moderately. A similar, but less pronounced pattern, was seen in the siblings of AUD versus control probands. These differences were much larger in male than in female siblings.
Conclusions
The factors that drove upward population rates of DUD in Sweden (e.g. increased availability, reduced stigma) produced much stronger effects in high-risk subjects (siblings of DUD and AUD probands) than in normal risk groups (siblings of controls), thereby increasing familial aggregation of DUD. However, parallel declines in AUD rates in high-risk versus normal-risk siblings were observed, likely due to ‘competitive effects’ reducing coaggregation of DUD and AUD. Results of genetic studies of substance use disorders can be substantially impacted by changes in availability and stigma of psychoactive substance use and indirectly by ‘competition’ as predicted by behavioral economic models, between abusable substances.
Let $\Sigma _g$ be a closed oriented surface of genus g. In this article, we discuss how to define coloring invariants and their generalizations for links in $\Sigma _g\times S^1$.
This study investigated the neural mechanisms underlying bilingual speech perception of competing phonological representations. A total of 57 participants were recruited, consisting of 30 English monolinguals and 27 Spanish-English bilinguals. Participants passively listened to stop consonants while watching movies in English and Spanish. Event-Related Potentials and sLORETA were used to measure and localize brain activity. Comparisons within bilinguals across language contexts examined whether language control mechanisms were activated, while comparisons between groups assessed differences in brain activation. The results showed that bilinguals exhibited stronger activation in the left frontal areas during the English context, indicating greater engagement of executive control mechanisms. Distinct activation patterns were found between bilinguals and monolinguals, suggesting that the Executive Control Network provides the flexibility to manage overlapping phonological representations. These findings offer insights into the cognitive and neural basis of bilingual language control and expand current models of second language acquisition.
As this article is being finalized, US President Donald J. Trump has taken numerous executive actions to challenge gender identity; diversity, equity, and inclusion (DEI) programs; and the rights of marginalized populations broadly. These xenophobic, anti-gender political agendas are gaining momentum worldwide (Ayoub and Stoeckle 2024). My hope is that these brief words inspire future politics and gender scholars to apply their research skills to challenge these heteropatriarchal policies that so often reinforce sexism, racism, and homophobia in the name of nationalism. When the Politics & Gender journal began in 2005, the justification question underlying much of its existence was “Does gender matter?” In 2025, if one is to measure the importance of gender by the amount of resistance to gender inclusive policies and feminist advances, one could easily argue that not only does gender matter-but it matters even more.
By exploring Adam Smith’s considerations of arts, this paper stresses that the philosopher establishes a profound connection between music and sympathy. In his essay “Of the Nature of that Imitation which takes place in what are called The Imitative Arts,” Smith delves into esthetic theory, dedicating a significant portion of the text to music and its role in eliciting pleasure and emotions. While previous studies have acknowledged the presence of art-related vocabulary and an esthetic dimension in The Theory of Moral Sentiments, they have not comprehensively mobilized his art essay to illuminate his moral theory. Following this unexplored path, this paper rallies the parallel Smith creates between emotions and musical aspects, such as rhythm and melody, to find a connection between his esthetic and moral ideas. In essence, it reveals how the human esthetic sensibility to look for regularities and order serves as a foundational element in Smith’s understanding of sympathy and social harmony.
Many erroneous literal translations, often produced by low-proficiency bilinguals, can be attributed to a tendency to favor typical translation equivalents; however, the underlying neural mechanism remains poorly understood. This study investigated this typicality effect in real-time translation with the event-related brain potential (ERP) technique. Mandarin Chinese–English bilinguals were presented with a Chinese verb phrase (e.g., kāi chuānghù “open the window” or kāi diànnăo “turn on the computer”) followed by an English verb (e.g., open (a typical translation) or turn on (an atypical translation)) and judged whether the English verb was an appropriate/congruent translation of the verb in the Chinese verb phrase previously presented (e.g., kāi). Compared to typical translation equivalents, atypical equivalents elicited an N400, indicating retrieval difficulty, and an f-PNP in congruent trials, reflecting the effort to inhibit typical translations and integrate atypical ones. This pattern may arise from differences in resting-level activation between typical and atypical equivalents.
In 2023 all Supplemental Nutrition Assistance Program (SNAP) participants were allowed to start grocery shopping online. This paper provides the first answer to the question: What is online shopping worth to the SNAP participant in dollars? Using meal-kit pricing and time-use data, an implicit wage rate and dollar value distribution are estimated for time saved in home food production from online grocery shopping. We report the 95th, 75th, 50th, 25th, and 5th percentile results. We simulate saving 50%, 75%, and 90% of grocery shopping time and estimate the savings per hour per meal. For example, if online shopping saved 75% of shopping time, the median saving per hour per meal would be $2.59. If a family of four made 15 to 30 meals a month, this corresponds to an implicit 5% to 11% increase in the benefits per month due to the time saved. The implicit wage rate provides simple and elegant economic insights into many aspects of food production and consumption not obtainable by just considering the money price.
Parkinson’s disease (PD) is a prevalent neurological disorder and the second most common neurodegenerative disease. Research has explored the impact of infectious agents, such as the parasites, on neurological conditions, including PD. Given the limited studies worldwide and in Iran, this study aims to investigate the relationship between Toxocara infection and PD. This case-control study involved 91 PD patients and 90 healthy controls. After obtaining consent, serum samples and questionnaires were collected. All sera were examined using an ELISA test for IgG antibodies against Toxocara canis. Results were analyzed with SPSS, using chi-square tests, and odds ratios (OR), and confidence intervals (CI) were calculated via univariate and multivariate analyses. The prevalence of anti-Toxocara IgG was 33% (30/91) in PD patients and 33.3% (30/90) in the control group. Both univariate analysis (OR: 0.98; 95% CI: 0.52–1.82) and multivariate analysis (OR: 0.95; 95% CI: 0.49–1.83) indicated no statistically significant association. Additionally, univariate analysis (OR: 0.49; 95% CI: 0.16–1.5) and multivariate analysis (OR: 0.37; 95% CI: 0.09–1.43) suggested non-significant association between Toxocara infection and the severity of PD. Our findings do not support a statistically significant association between Toxocara infection and the PD. While the analysis suggested that Toxocara infection might reduce the severity of PD, these results were also not statistically significant. Further research with larger sample sizes and diverse populations is needed to fully understand the potential relationship between Toxocara infection and PD.
This is the first report of the blow fly, Calliphora stelviana (Brauer and Bergenstamm, 1891) (Diptera: Calliphoridae), at low elevation in southern Canada. Specimens were collected using liver-baited traps in autumn 2020 within the Windsor–Essex County region of southwestern Ontario, Canada. Previously, this species has been known to inhabit Alaska and the higher altitudes of Colorado, in the United States of America, and central Saskatchewan and northern Québec, in Canada.
We solve a problem posed by Calabi more than 60 years ago, known as the Saint-Venant compatibility problem: Given a compact Riemannian manifold, generally with boundary, find a compatibility operator for Lie derivatives of the metric tensor. This problem is related to other compatibility problems in mathematical physics, and to their inherent gauge freedom. To this end, we develop a framework generalizing the theory of elliptic complexes for sequences of linear differential operators $(A_{\bullet })$ between sections of vector bundles. We call such a sequence an elliptic pre-complex if the operators satisfy overdetermined ellipticity conditions and the order of $A_{k+1}A_k$ does not exceed the order of $A_k$. We show that every elliptic pre-complex $(A_{\bullet })$ can be ‘corrected’ into a complex $({\mathcal {A}}_{\bullet })$ of pseudodifferential operators, where ${\mathcal {A}}_k - A_k$ is a zero-order correction within this class. The induced complex $({\mathcal {A}}_{\bullet })$ yields Hodge-like decompositions, which in turn lead to explicit integrability conditions for overdetermined boundary-value problems, with uniqueness and gauge freedom clauses. We apply the theory on elliptic pre-complexes of exterior covariant derivatives of vector-valued forms and double forms satisfying generalized algebraic Bianchi identities, thus resolving a set of compatibility and gauge problems, among which one is the Saint-Venant problem.
Representations of the human body are ubiquitous in cultures across the world. Beyond the aesthetic, figurines transmit deeper meanings that were readily decodable by their intended audience and may still offer sociocultural insights despite the loss of this coding through time. The discovery of a rare tableau of ‘Bolinas’-type clay figurines dating to 410–380 BC at San Isidro, El Salvador, now permits the theoretical reconstruction of a less stratified Preclassic society in south-east Mesoamerica and the exploration of its spheres of interaction, which may have stretched along the coast from Guatemala to Costa Rica.
Over a hundred gravitational-wave signals have now been detected from the mergers of black holes and neutron stars, but other sources of gravitational waves have not yet been discovered. Some of the most violent explosive events in the Universe are predicted to emit bursts of gravitational waves and may result in the next big multi-messenger discovery. Gravitational-wave burst signals often have an unknown waveform shape and unknown gravitational-wave energy, due to unknown or very complicated progenitor astrophysics. Potential sources of gravitational-wave bursts include core-collapse supernovae, cosmic strings, fast radio bursts, eccentric binary systems, and gravitational-wave memory. In this review, we discuss the astrophysical properties of the main predicted sources of gravitational-wave bursts and the known features of their gravitational-wave emission. We summarise their future detection prospects and discuss the challenges of searching for gravitational-wave burst signals and interpreting the astrophysics of the source.
Plastic pollution is a global issue, with microplastics gaining international attention from Non-governmental organizations (NGOs), the government, the public, media and academia; microplastics are a growing source of concern. This research article aims to explore the Cape Town beachgoers’ general knowledge and understanding of microplastic pollution in terms of its potential effects on the environment and human health. Using a questionnaire, the study was conducted at Muizenberg and Lagoon Beach, and involved participants belonging to the age group of <18–64 years. A sampling technique known as convenience sampling was used. This technique allowed individuals to be selected based on their willingness to be part of the sample and their availability; it allowed participants with no obvious knowledge of microplastics to take part. The data were recorded in Excel and analysed with the Statistical Package Social Sciences. Although the public was relatively familiar with microplastics at the time of the study, 40% of the participants from Muizenberg Beach did not know what microplastics are, while 60% knew. In Lagoon Beach, 26.67% did not know what microplastics are, while 73.33% did. Environmental education and the prohibition of microplastics were identified by the majority of respondents as necessary measures for reducing microplastic pollution and further research was suggested, with some of the respondents believing that the lack of strict regulations on plastic use was the greatest difficulty in reducing the pollution from microplastics.