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Functional movement disorders are the most challenging movement disorders to diagnose and treat. Phenomenology and disease course are variable. This group of disorders includes tremor, dystonia, myoclonus, parkinsonism, speech and gait disturbances, and other movement disorders that are incongruent with patterns of pathophysiologic (organic) disease.
The enactment of the European Non-Financial-Reporting-Directive (2014/95/EU) and the new (proposed) Corporate-Sustainability-Reporting-Directive as its successor introduced aspects of corporate social responsibility to the world of financial reporting for almost all listed corporations in the common market. This established a path dependency between the traditional financial and the (new) non-financial reporting regime. As the consequence, the actual non-financial reporting regime does not provide a unique scope of application and does not distinguish between business entities with and without an impact on corporate social responsibility. Nevertheless, the actual content of financial reporting and non-financial reporting is fundamentally different since financial information is a number-based information instrument and sustainability information is a text-based information instrument. Moreover, financial information and non-financial information do not require the same corporate governance procedure for drafting and examining. Finally, it is doubtful that the liability regime of financial disclosure can be used as some kind of blueprint for a civil liability regime for non-financial disclosure. Since the existing framework for civil liability in financial disclosure cannot be used for cases of incorrect non-financial disclosure, it is necessary to develop an independent regime of civil liability for incorrect non-financial disclosure. The existing path dependency between financial and non-financial disclosure prevents this necessary step.
The previous study indicated that ubiquitination is involved in the freezing tolerance of hydrated seeds. Parthenolide (PN), inducing the ubiquitination of MDM2, an E3 ring-finger ubiquitin ligase, adversely affects the freezing tolerance of hydrated lettuce seeds. Therefore, a proteomics analysis was conducted to identify PN's targets in hydrated seeds exposed to cooling conditions. Several pathways, including oxidative phosphorylation (KEGG00190), amino sugar and nucleotide sugar metabolism (KEGG00520), and biosynthesis of nucleotide sugars (KEGG01250), were enriched in the PN treatment under slow-cooling conditions (3°C h−1, P < 0.05). Among the proteins in oxidative phosphorylation, the expression of NADH dehydrogenases and ATP synthases (ATPsyn) decreased in PN treatment. In contrast, uncoupling proteins increased after PN treatment, which led to the dissociation of the electron transport chain from ATP synthesis. Treatments with rotenone, dicoumarol, and oligomycin (i.e., oxidative phosphorylation inhibitors) decreased the survival rate of hydrated seeds under freezing conditions, which indicated that energy metabolism was related to the freezing tolerance of hydrated seeds. The predicted interactions between PN and MDM2-like proteins of Lactuca indicated that LsMDM2-5 forms two potential hydrogen bonds with PN. Furthermore, based on AlphaFold predictions and yeast 2-hybrid results, MDM2-5 might interact directly with NADH2. The knockdown of MDM2-5 by RNAi caused a higher level of NADH2 and ATPsyn and a higher freezing tolerance of hydrated seeds. This indicated that MDM2 played negative roles in regulating ATP synthesis and freezing tolerance of hydrated seeds.
Bycatch, the incidental capture of non-target species in fishing gear, has been recognised as the most significant global conservation threat affecting seabird species. Geographically, bycatch rates vary widely, depending on local fishing efforts, environmental features, and seabird community composition. Regional and local research is essential due to the complexity of accurately extrapolating general conclusions regarding the impacts of bycatch. Existing European bycatch research predominantly focuses on northern regions, leaving a significant knowledge gap regarding bycatch in the Mediterranean Sea. This work presents findings of wintering diving seabirds as bycatch of small-scale fisheries in a coastal area of the northern Adriatic Sea, based on data collected between 2021 and 2023. Seabird distribution varied along the depth profile. The bathymetric range between 3 m and 5 m was the most exploited by fishermen. Bycatch of seabirds was confirmed in the study area, with five species recorded, i.e. Black-necked Grebe Podiceps nigricollis, Red-throated Loon Gavia stellata, Black-throated Loon Gavia arctica, Mediterranean Shag Gulosus aristotelis desmarestii, and Great Crested Grebe Podiceps cristatus. Our results suggest that bathymetry likely plays a strong influence on bycatch occurrence. Incidental captures were not widespread but appeared concentrated in the shallowest depths <5 m and the range <2.5 m was identified as particularly susceptible due to the low associated fishing effort and the majority of bycatch events recorded. We estimate that between 46 and 108 birds were incidentally captured during the research period. This study identifies key factors shaping the areas of bycatch vulnerability and risk, proposing a spatial–temporal mitigation framework within Natura 2000 sites and highlighting the value of local stakeholders’ engagement.
This chapter explores the various ways that liberal internationalism has sought to use international institutions to build cooperative systems of order. I start by outlining liberal internationalism’s tradition of thinking about institutions and peaceful change. Liberalism and liberal internationalism are defined by their deep assumptions about modernity, development, and progress as well as by their focus on the challenges of adapting liberal democracy and international order to modernization and rising interdependence. After this, I turn to five system-structural “problems” that liberal internationalism has grappled with over the past two centuries. These are the problems of anarchy, hierarchy, interdependence, liberal openness, and geopolitical vulnerability. Across millennia, the two dominant forms of international order have been either anarchy or hierarchy. Liberal internationalism has been deeply entangled with both types of order. Yet, despite this, its overall ideas and projects have been oriented toward creating a “third way” between anarchy and hierarchy. In all these pursuits, liberals have used institutions as tools and ordering arrangements to solve problems and promote peaceful change.
The striking image of three local Chinese women spectators at the Bandung Conference of 1955 was taken by Lisa Larsen, who was a photographer commissioned by LIFE magazine to cover the conference. What does this photograph tell us about international diplomacy? Was it a coincidence that the female photographer happened to take one of the most visually arresting photographs of women as diplomatic spectators? This chapter proposes to probe further the significance of gender in constructing images of international diplomacy. In general, visual sources of international diplomacy tend to portray women in multiple capacities as actors on the international stage. However, this stands in stark contrast to textual sources, which reveal very little female agency, mostly due to the narrowly defined notions of who constitutes a diplomatic actor in traditional approaches to studying diplomacy. Elsewhere, the author has argued that the invisibility of women in diplomacy can in itself be seen as a performative stance. In this chapter, she explores how we can ‘recover’ the lost female presence in diplomacy by privileging the female gaze, through the iconic female photographer.
Jiří Adámek, Czech Technical University in Prague,Stefan Milius, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany,Lawrence S. Moss, Indiana University, Bloomington
The theme of this chapter is the relation between the initial algebra for a set functor and the terminal coalgebra, assuming that both exist and that the endofunctor is non-trivial. We introduced a notion called pre-continuity. Pre-continuous set functors generalize finitary and continuous set functors. For such functors, the initial algebra and the terminal coalgebra have the same Cauchy completion and the same ideal completion: the $\omega$-iteration of the terminal-coalgebra chain. It follows that for a non-trivial continuous set functor, the terminal coalgebra is the Cauchy completion of the initial algebra.
I write this book to convince you of the importance of studying ancient Greek history. I argue that Greek antiquity was exceptional and consequential. It was contingent – it did not have to be the way it was. And it was decisive, helping to shape what followed.
The contio was vital to the political conversation between the senate and people, creating a shared political space. Its success was not so much rooted in the institutional framework but in the contiones’ ability to connect with the audience’s lived experience. In particular, the nobility’s leadership was found acceptable because it was portrayed as beneficial to all; aristocrats were able to substantiate their claims for social eminence with real assets. The capacity to create consensus by means of a set decision-making process faded over time. The second half of the article traces the growing involvement of the contio with domestic issues since the time of the Gracchi, if not earlier. While promises of spoils and profit remained a recurring theme in public speech, they appeared less and less believable. The political crisis of the late Republic was thus also a crisis in the communication between mass and elite. The consensus evaporated because its inherent benefits had fallen flat: the contio became an outlet of discontent and communications counterintuitive to the preservation of the libera res publica.
Parkinsonism is used to describe a clinical syndrome of bradykinesia, rest tremor, rigidity and postural instability, and is present in a many sporadic and genetic disorders. The most common cause of parkinsonism is Parkinson’s disease (PD). Typical parkinsonism is characterized by asymmetry, slow progression, and excellent L-Dopa response, whereas atypical parkinsonism is parkinsonism with additional features (oculomotor abnormalities, myoclonus, cerebellar and pyramidal signs, ataxia), faster progression, and poor L-Dopa response. The genetic landscape of parkinsonism may be divided into monogenic variants; oligo- and polygenic forms of (a)typical parkinsonism; and intermediate variants with incomplete penetrance and low frequency. Typical and atypical parkinsonisms are reviewed, presenting and discussing 101 genes and loci associated with parkinsonism, classified based on phenotype into autosomal-dominant typical parkinsonisms, autosomal-recessive (a)typical parkinsonisms, other genetic forms of (a)typical parkinsonisms, and genetic syndromes with features of atypical parkinsonism. Genetic susceptibility and issues related to diagnostic genetic tests are also discussed.
Physical rehabilitation in people with Parkinson’s disease (PD) aims to restore everyday functioning and mobility through a multidisciplinary approach. We present and discuss the current evidence on efficacy of key rehabilitation specialties and therapies that contribute to improving everyday (motor and non-motor) functioning in PD. Rehabilitative therapies aiming to improve posture and balance, transfers, gait, and physical condition have been shown effective. Evidence that physical therapy interventions using for example external or internal cues is effective for improving gait and gait-related mobility is strong, although the evidence for improving upper limb function, speech, and swallowing deficits is still limited. Optimal intensity of rehabilitation services offered by physical therapists, occupational therapists, and speech therapists, as well as their active ingredients and long-term impact, need further underpinning to help continuing development and updating of clinical guidelines.
Members of the Shewanella genus transfer electrons to metal and actinide electron acceptors such as hexavalent uranium, U(VI), via c-type cytochromes. The intracellular mechanism of electron transfer is well studied but the delivery of electrons to external electron acceptors less well so. MtrC, a decaheme c-type cytochrome located on the cell surface side of the outer membrane of many Shewanella species, and extending to the extracellular medium, transfers electrons to U(VI), both in vivo and in vitro when purified. However, it is unclear how the electron transfer between the terminal heme(s) of the protein and extracellular U(VI) occurs. In particular, the type of interaction between MtrC and U(VI), and the parameters controlling electron transfer remain to be elucidated. Here, we investigated the kinetics of U(VI) reduction by S. baltica MtrC in solution for U(VI) complexed with one of five ligands: carbonate, hydroxyl, citrate, nitrilotriacetic acid (NTA) or ethylenediaminetetraacetic acid (EDTA). We observed two initial reaction rates, one more rapid for U-citrate, U-NTA and U-EDTA, and another slower for U-carbonate and U-hydroxo. By combining Nuclear Magnetic Resonance spectroscopy and M4-edge High Resolution X-ray Absorption Near Edge Structure spectroscopy, we attributed these differences to the type of interaction between the U-ligand complex and MtrC, i.e., probably electrostatic interaction with the ligand of U-EDTA, hydrogen bonding to the ligand of U-citrate and U-NTA, and covalent bonding with U-carbonate and U-hydroxo. We also demonstrate the persistence of U(V) in the U-carbonate system when interacting with MtrC. Overall, we showed that the mechanism of electron transfer depended on the chemistry of the soluble U(VI) complex serving as the substrate.