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Ces dernières décennies, certains travaux ont cherché à montrer que le plus-que-parfait tend à développer des emplois de passé perfectif dépourvus de toute notion d’antériorité. Le but du présent article est de reconsidérer ces analyses, en accordant davantage d’importance à l’anaphoricité de ce temps verbal. Après avoir rappelé les principales propriétés du plus-que-parfait, l’auteur note que les exemples discutés dans ces travaux concernent essentiellement deux contextes d’emploi. Plusieurs de ces exemples sont ici repris et réanalysés. L’auteur en conclut que ces travaux sous-estiment le rôle de l’implicite dans le fonctionnement anaphorique du plus-que-parfait, en exigeant inutilement la présence d’une expression temporelle susceptible d’interpréter l’anaphorique (antécédent). Il en résulte que l’hypothèse parfois avancée d’une aoristisation de ce temps verbal, outre son coût théorique, s’avère inappropriée.
The stage and its architectural features provided an entire world in and of themselves. In the words of Sarah Dustagheer, ‘In general terms, the early modern playhouse had a cosmic verticality in its architectural structure with a stage roof painted like the heavens, situated above a trapdoor onstage that led down to Hell or an underworld beneath the stage, and thus the platform itself represented the earth filled with human actions’ – and often, we might add, filled with trees for humans to hide behind (Dustagheer 2017, 115).
Can United Nations peace operations improve their effectiveness and strengthen longer-term positive legacies in host nations by shifting to greater use of renewable energy? Since the end of the Cold War and the growth of modern UN peace operations, attention has been focused on the missions’ mandate of supporting political strategies for peace and core objectives such as protecting civilians. Could missions better meet their mandate with improved energy options and reduced emissions, or is there a trade-off with the core objectives? As the missions are nearly fully dependent on diesel generators to power their operations, what is the UN’s responsibility to reduce emissions at a time when addressing climate change is a priority of the UN Secretary-General? Is there an ethical case to make for the UN to support greater use of renewable energy where it operates? And could the UN partner with host nations and others to support a shift in energy use that benefits the communities that host peace operations? This essay argues that missions could reduce their emissions and leverage their energy needs to increase security, strengthen ties to local communities, increase energy access, and support the climate goals of host nations. Drawing on case studies in recent peacekeeping missions and the author’s review of UN commitments across mandates, the Sustainable Development Goals, peacebuilding, and climate goals, this essay will address this area of potential innovation that can help build a positive legacy for UN missions and countries emerging from conflict.
In the early modern playhouse, a play by Shakespeare was not the self-contained theatrical event we’ve come to think of it as today. Before taking a place in the playhouse, a London playgoer might have encountered many other forms of impromptu entertainment on the streets: games, sports, morris dances, singing, and conjuring tricks. Indeed, the first dramatic words a playgoer heard may not have been the opening lines of the plays themselves, but the lyrics of a ballad sung by a ‘balladmonger’ who also sold the printed texts of the narrative songs he or she sang.
Clostridiodes difficile’s epidemiology has evolved over the past decades, being recognized as an important cause of disease in the community setting. Even so, there has been heterogeneity in the reports of CA-CDI. Therefore, the aim of this study was to assess the epidemiologic profile of CA-CDI.
This systematic review and meta-analysis were conducted according to PRISMA checklist and Cochrane guidelines (CRD42023451134). Literature search was performed by an experienced librarian from inception to April 2023, searching in databases like MEDLINE, Scopus, Web of Science, EMBASE, CCRCC, CDSR, and ClinicalTrials. Observational studies that reported prevalence, incidence of CA-CDI, or indicators to calculate them were included. Pool analysis was performed using a binomial-normal model via the generalized linear mixed model. Subgroup analysis and publication bias were also explored. A total of 49 articles were included, obtaining a prevalence of 5% (95% CI 3–8) and an incidence of 7.53 patients (95% CI 4.45–12.74) per 100,000 person-years.
In conclusion, this meta-analysis underscores that among the included studies, the prevalence of CA-CDI stands at 5%, with an incidence rate of 7.3 cases per 100,000 person-years. Noteworthy risk factors identified include prior antibiotic exposure and age.
Suicidal thoughts and behaviors (STBs) are a major concern in people with psychotic disorders. There is a need to examine their prevalence over long-term follow-up after first-episode psychosis (FEP) and determine their early predictors.
Methods
Of 510 participants with FEP evaluated on 26 risk factors for later outcomes, 260 were reassessed after 21 years of follow-up for lifetime ratings of most severe suicidal ideation, number of suicide attempts, and lethality of the most severe attempt. Risk factors and STB outcomes were modeled using hierarchical linear regression analysis.
Results
Over the 21-year follow-up period, 62.7% of participants experienced suicidal thoughts, 40.8% attempted suicide, and 18 died of suicide (3.5% case fatality and 20.6% proportionate mortality). Suicidal ideation was independently predicted by parental socioeconomic status, familial load of major depression, neurodevelopmental delay, poor adolescence social networks, and suicidal thoughts/behavior at FEP. The number of suicide attempts was independently predicted by years of follow-up, familial load of major depression, obstetric complications, childhood adversity, and suicidal thoughts/behavior at FEP. Lethality was independently predicted by familial load of major depression, male sex, neurodevelopmental delay, and poor adolescence social networks. The proportion of variance in suicidal ideation, attempts, and lethality explained by the independent predictors was 29.3%, 21.2%, and 18.1%, respectively.
Conclusions
STBs are highly prevalent in psychotic disorders and leads to substantial morbidity and mortality. They were predicted by a number of early risk factors, whose clinical recognition should contribute to improved prediction and prevention in people with psychotic disorders.
The global analogue of a Henselian local ring is a Henselian pair – a ring R and an ideal I which satisfy a condition resembling Hensel’s lemma regarding lifting coprime factorizations of monic polynomials over $R/I$ to factorizations over R. The geometric counterpart is the notion of a Henselian scheme, which can serve as a substitute for formal schemes in applications such as deformation theory.
In this paper, we prove a GAGA-style cohomology comparison result for Henselian schemes in positive characteristic, making use of a ‘Henselian étale’ topology defined in previous work in order to leverage exactness of finite pushforward for abelian sheaves in the étale topology of schemes. We will also discuss algebraizability of coherent sheaves on the Henselization of a proper scheme, proving (without a positive characteristic restriction) algebraizability for coherent subsheaves. We can then deduce a Henselian version of Chow’s theorem on algebraization and the algebraizability of maps between Henselizations of proper schemes.
Novel ultrasound neuromodulation techniques allow therapeutic brain stimulation with unmet precision and non-invasive targeting of deep brain areas. Transcranial pulse stimulation (TPS), a multifrequency sonication technique, is approved for the clinical treatment of Alzheimer’s disease (AD). Here, we present the largest real-world retrospective analysis of ultrasound neuromodulation therapy in dementia (AD, vascular, mixed) and mild cognitive impairment (MCI).
Methods
The consecutive sample involved 58 patients already receiving state-of-the-art treatment in an open-label, uncontrolled, retrospective study. TPS therapy typically comprises 10 sessions (range 8–12) with individualized MRI-based target areas defined according to brain pathology and individual pathophysiology. We compared the CERAD-Plus neuropsychological test battery results before and after treatment, with the CERAD Corrected Total Score ( CTS) as the primary outcome. Furthermore, we analyzed side effects reported by patients during the treatment period.
Results
CERAD Corrected Total Score (CTS) significantly improved (p = .017, d = .32) after treatment (Baseline: M = 56.56, SD = 18.56; Post-treatment: M = 58.65, SD = 19.44). The group of top-responders (top quartile) improved even by 9.8 points. Fewer than one-third of all patients reported any sensation during treatment. Fatigue and transient headaches were the most common, with no severe adverse events.
Conclusions
The findings implicate TPS as a novel and safe add-on therapy for patients with dementia or MCI with the potential to further improve current state-of-the-art treatment results. Despite the individual benefits, further randomized, sham-controlled, longitudinal clinical trials are needed to differentiate the effects of verum and placebo.
Cleavers, an annual or winter annual broadleaf weed in the Rubiaceae family, has become troublesome in the wheat fields of the Huang-Huai-Hai region in China due to its herbicide resistance. In North America the common name of the plant is stickwilly; in China it known as cleavers. Four populations of cleavers (JS-15, SD-10, JS-22, and AH-20) were collected from wheat fields in Jiangsu, Shandong, and Anhui provinces, where the plant was not being controlled with applications of florasulam. The aims of this study were to identify the herbicide resistance patterns and investigate the mechanism underlying florasulam resistance. Whole-plant dose-response experiments revealed a notable variation in the degree of resistance exhibited by three specific populations toward florasulam, in comparison to the most sensitive population (S and AH-9), with the highest resistance index reaching 841.4. A gene-sequencing assay for acetolactate synthase (ALS) found that plants that were resistant to ALS from the JS-15, JS-22, and AH-20 populations had a Trp-574-Leu mutation, while no known ALS resistance mutations were discovered in SD-10 plants. In vitro ALS enzyme activity assays also indicated that the extractable ALS from JS-15, JS-22, and AH-20 plants was greatly resistant to florasulam relative to plants that are susceptible. Additionally, according to the resistance rating system, all resistant populations were susceptible to carfentrazone-ethyl + MCPA-sodium and bipyrazone + fluroxypyr-methyl. AH-20, JS-15, and JS-22 exhibited resistance to selected ALS, 4-hydroxyphenylpyruvate dioxygenase (HPPD), and photosystem II (PS II) complex inhibitors, demonstrating RR and RRR resistance profiles, whereas AH-9 displayed sensitivity to virtually all tested agents. The SD-10 population, on the other hand, exhibited RR and RRR resistance to HPPD and PS II inhibitors, and sensitivity to tribenuron-methyl. These findings indicate that a target site–based mechanism drives resistance to the ALS inhibitor florasulam in populations of cleavers, but nontarget site resistance may also have contributed to resistance, but this was not investigated. Other herbicides with different sites of action were tested and were active against cleavers.
It would be ideal if history had gifted us an accurate picture of what each of these spaces was like. Sadly, that couldn’t be further from the case: we have no complete picture of any of the London playing spaces from the period, and much of what we (think we) know of the Globe and the Blackfriars can only been inferred from evidence relating to other playing spaces. Reconstructing these spaces requires piecing together fragments: chiefly, the architectural foundations of the Rose, Curtain, and Theatre playhouses, along with a tiny portion of the Globe, and a copy of a Dutch tourist’s sketch of the Swan playhouse’s interior.
As with all other evidence relating to the London playhouses, the records we have of who actually visited theatres like the Globe and Blackfriars is patchy, and sometimes contradictory. In 1594, the Lord Mayor himself complained that playhouses were ‘the ordinary places of meeting for all vagrant persons & masterless men that hang about the City, thieves, horse-stealers, whoremongers [pimps], cozeners [fraudsters], coney-catching persons [tricksters], practisers of treason, & other such like’ (qtd. in Gurr 1996, 218).
Evidence for what the Globe looked like in any sort of detail is scrappy and divergent indeed. Unfortunately for us, two of the best pieces of pictorial evidence we have do not depict the Globe that was built in 1599 at all, but the second Globe, rebuilt in 1614 on the foundations of the first playhouse after it burned down mid-performance.
Among the remains excavated at the site of the Rose playhouse in Southwark are a number of nutshells, seeds from fruit of all kinds, remnants of bread, and waste from shellfish including oysters, then much less of a luxury than they are today (Bowsher 2012, 190; Gurr 2009, 161–2).
In order to evaluate the seasonal responses of periphytic protozoan fauna to the antibiotic nitrofurazone at sensitive concentration, a 1-year baseline survey was carried out in Chinese coastal waters of the Yellow Sea. To assess the nitrofurazone (NFZ)-induced toxicokinetics in different season, the test protozoan samples were collected using microscope slides and exposed to the sensitive NFZ concentration of 8 mg ml−1. Differences in species composition and typical species were observed in the test organism fauna in the control and treatment among four seasons. However, the community patterns were significantly shifted under the sensitive concentration, with a part of stressed test samples significantly departed from a respected taxonomic pattern. Therefore, it is suggested that periphytic protozoan fauna may be significantly changed at the same sensitive concentration in both the species composition and community pattern, although there were significant differences in tolerant species among four seasons in marine environments.