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Assumptions in studies of heritability and genotype–phenotype association

Published online by Cambridge University Press:  24 October 2012

Michael B. Miller ,
Colin G. DeYoung  and
Matt McGue
Michael B. Miller
Affiliation:
Department of Psychology, University of Minnesota, Minneapolis, MN 55455. [email protected]://scholar.google.com/citations?user=EV_phq4AAAAJ&[email protected]://www.tc.umn.edu/~cdeyoung/
Colin G. DeYoung
Affiliation:
Department of Psychology, University of Minnesota, Minneapolis, MN 55455. [email protected]://scholar.google.com/citations?user=EV_phq4AAAAJ&[email protected]://www.tc.umn.edu/~cdeyoung/
Matt McGue
Affiliation:
Department of Psychology, University of Minnesota, Minneapolis, MN 55455. [email protected]://scholar.google.com/citations?user=EV_phq4AAAAJ&[email protected]://www.tc.umn.edu/~cdeyoung/ Department of Epidemiology, University of SouthernDenmark, DK-5000 Odense C, Denmark. [email protected]://www.psych.umn.edu/people/faculty/mcgue.htm
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Abstract

Charney's dismissal of well-established methods in behavioral genetic research is misguided. He claims that studies of heritability and genetic association depend for their validity on six assumptions, but he cites no sources to support this claim. We explain why none of the six assumptions is strictly necessary for the utility of either method of genetic analysis.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 35 , Issue 5 , October 2012 , pp. 372 - 373
Copyright
Copyright © Cambridge University Press 2012 

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References

Alford, J. R., Funk, C. L. & Hibbing, J. R. (2005) Are political orientations genetically transmitted? American Political Science Review 99(2):153–67.Google Scholar
Bell, J. T. & Spector, T. D. (2011) A twin approach to unraveling epigenetics. Trends in Genetics 27(3):116–25. doi:10.1016/j.tig.2010.12.005.CrossRefGoogle ScholarPubMed
Bouchard, T. J. & Loehlin, J. C. (2001) Genes, evolution, and personality. Behavior Genetics 31(3):243–73.Google Scholar
Bouchard, T. J. & McGue, M. (1981) Familial studies of intelligence: A review. Science 212(4498):1055–59. doi:10.1126/science.7195071.Google Scholar
Devlin, B., Daniels, M. & Roeder, K. (1997) The heritability of IQ. Nature 388:468–71.Google Scholar
Haworth, C. M. A., Wright, M. J., Luciano, M., Martin, N. G., de Geus, E. J. C., van Beijsterveldt, C. E. M., Bartels, M., Posthuma, D., Boomsma, D. I., Davis, O. S. P., Kovas, Y., Corley, R. P., DeFries, J. C., Hewitt, J. K., Olson, R. K., Rhea, S.-A., Wadsworth, S. J., Iacono, W. G., McGue, M., Thompson, L. A., Hart, S. A., Petrill, S. A., Lubinski, D. & Plomin, R. (2010) The heritability of general cognitive ability increases linearly from childhood to young adulthood. Molecular Psychiatry 15(11):1112–20. doi: 10.1038/mp.2009.55.Google Scholar
Neale, M. C. & Cardon, L. (1992) Methodology for genetic studies of twins and families. Kluwer Academic.Google Scholar
Vinkhuyzen, A. A. E., van der Sluis, S., Maes, H. H. M. & Posthuma, D. (2012) Reconsidering the heritability of intelligence in adulthood: Taking assortative mating and cultural transmission into account. Behavior Genetics 42:187–98.Google Scholar
Wright, S. (1920) The relative importance of heredity and environment in determining the piebald pattern of guinea pigs. Proceedings of the National Academy of Sciences 6:320–32.CrossRefGoogle ScholarPubMed
Zwijnenburg, P. J. G., Meijers-Heijboer, H. & Boomsma, D. I. (2010) Identical but not the same: The value of discordant monozygotic twins in genetic research. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics 153B(6):1134–49. doi: 10.1002/ajmg.b.31091.Google Scholar