This chapter deals with the pharmacotherapy of motor clinical hallmarks in Parkinson’s disease (PD), plus other PD and/or its intervention-related signs and symptoms. The treatment of PD-related non-dopaminergic symptoms such as mainly autonomic, neuropsychiatric and sleep–wake disorders are extensively dealt with in other chapters, so the pharmacotherapy of these disorders are only be discussed briefly. Autonomic non-motor fluctuations comprise cardiovascular (orthostatic hypotension), urogenital (detrusor over- and underactivity-related problems, e.g., urgency, frequency, nocturia, hesitation and straining), and gastrointestinal manifestations (sialorrhea, dysphagia, delayed gastric emptying, constipation). Depression and (mild) cognitive impairment are the most important mainly direct PD-related neuropsychiatric disorders, whereas impulse control disorders, as well as dementia and psychosis, are frequently seen as dopaminomimetic adverse events. Sleep–wake disorders with parasomnias are also characteristic non-motor symptoms in PD. The tailored pharmacologic strategies in these non-dopaminergic symptoms are discussed in detail.

What is the aesthetic status of these interactions? I am tempted to answer: that is it, aesthetic. The answer to a further question, ’whose aesthetic?’, is implicit in my opening argument. The aesthetic must be dynamic, representing ’not a having and a resting, but a growing and a becoming’, as Matthew Arnold phrased the human ideal. It must accord with newly recognised possibilities of literature – of any literature – and equally with those long recognised. Above all, if it hopes to illuminate the particular literature in hand, it must be supported by that literature, must not supplant it.

De Lisser and Durrleman’s second chapter explores the syntax of missing subjects in the acquisition of creole languages by children. They focus on two Creoles – Jamaican, a non-null subject language, and Morisyen, a language which allows null subjects in certain contexts. The results of both cross-sectional and longitudinal analyses reveal striking similarities in the L1 acquisition of subjects in both Jamaican and Morisyen. Both languages start out with a grammar displaying predominantly target-inconsistent missing subjects, which later shifts to a grammar involving an overwhelming number of overt subjects. This development of subjects in the grammar of Creole-speaking children can be accounted for by the modified version of the Truncation approach in terms of the Spell-out mechanism (De Lisser et al., 2016). The initial structure reflects Universal Grammar, a system providing the option of truncation, and which gives rise to subject drop.

Adone’s chapter focuses on home signs, bringing to light the acquisition process against a background of ‘normless’ language environment (Bakker, this volume) and in the absence of exposure to a ‘conventional language model’ (Adone 2005). She thus discusses what absence of exposure means when looking at children home signers. In comparison to previous work, Adone shows that the absence of a conventional language model does not mean complete absence of input. She argues that children ‘scan’ their environment for input and use every bit of language-related information as input. Adone further argues that the verb chains in child home signers’ initial grammars develop into adult-like serial verb constructions. This development can be interpreted as evidence for the view that children exploit input to the best of their ability to ‘create language’.

Chapter 6 looks at how sectoral networks propelled the Anti-Extradition Movement. By focusing on religious groups, legal professionals, and medical practitioners, we demonstrate how social identities informed protesters what roles to take up during a spontaneous movement, and how these sectoral networks provided expertise and resources to facilitate the movement’s organizing efforts.

Chapter 7 examines how secondary school action groups, established by students in their respective schools, played a crucial role in mobilizing teenagers against the extradition bill by tapping into and leveraging their latent social capital. Utilizing Instagram as a platform, these groups facilitated connections among students within and across schools, often by capitalizing on their schools’ identities and leveraging various sources of social capital tied to those identities. This enabled loose and fragmented social networks can be mobilized in social movements, provided that they can activate their latent social capital.

Uwe Walter explains how memoria in Rome was rooted in institutions vital to the res publica. Many of these were embedded in an oral context with highly suggestive settings – public speech, the theatre, festival performances, among others. Hence, they had only a limited capacity to store memories and preserve them over time. In similar fashion, buildings and monuments were subject to decay, and with their splendour their memorial force vanished. Historiography was of a different quality. Fabius Pictor attempted to create a unified memory of the res publica, distilled and synthesized from multiple individual and collective repositories of memory across a variety of media – and charged with the authority of the senatorial voice. Two concluding case studies illustrate how Walter envisions the relation between narrative synthesis and the production of meaning: one, the case of L. Marcius Septimus, lower commander during the Punic Wars; and the other the highly politicized episode of ten high-ranking prisoners released after the battle of Cannae by Hannibal on their word of honour that they would raise a ransom in Rome in exchange for their comrades. Each tradition integrated different elements of memory to generate a qualitatively new knowledge of past events.

The conditional legal immunity for hosting unlawful content (safe harbour) provided by Section 79 of the Information Technology Act, 2000 (IT Act) is central to the regulation of online platforms in India for two reasons. First, absent this immunity, platforms in India risk being secondarily liable for a wide range of civil and criminal offences. Second, the Indian Government has recognised that legal immunity for user-generated content is key to platform operations and has sought to regulate platform behaviour by prescribing several pre-conditions to safe harbour. This chapter examines the different obligations set out in the Intermediary Guidelines and evaluates the efforts of the Indian government to regulate platform behaviour in India through the pre-conditions for safe harbour. This chapter finds that the obligations set out in the Intermediary Guidelines are enforced in a patchwork and inconsistent manner through courts. However, the Indian Government retains powerful controls over content and platform behaviour by virtue of its power to block content under Section 69A of the IT Act and the ability to impose personal liability on platform employees within India.

This book is not an attempt to apply to classical literature the habits of modem literary criticism, but as it might be supposed to be just that, I may as well forestall the supposition at the outset. Despite intermittent efforts in recent times, it is still comparatively rare for practising classicists to attempt such ’applications’ and, if anything, especially rare for Hellenists. But the present work represents something much less fashionable altogether: an attempt by a practising classicist to extend the ’theory’ of an aspect of literature in general in the practical context of the literature of antiquity. But in case the claim should seem unduly immodest, it can be said at once that the ’aspect of literature’ in question is, in itself, a small aspect, although not a trivial one. And by way of glossing the claim, let it be said also that the ’habits of modem literary criticism’ and the theoretical apparatus (if any) that accompanies them are not simply separable from their ’traditional’ counterparts. There is rather, as anyone familiar with the ancestry of modern criticism will know, a developing tradition, complex and many-sided, but continuous, which, in its development, sometimes modifies, sometimes innovates entirely and sometimes reconstitutes, in effect, earlier modes.

Corecursive algebras are algebras that admit unique solutions of recursive equation systems. We study these and a generalization: completely iterative algebras. The terminal coalgebra turns out to be the initial corecursive algebra as well as the initial completely iterative algebra. Dually, the initial algebra is the initial (parametrically) recursive coalgebra. These results explain the title of the chapter. We apply recursive coalgebras in order to obtain a new proof of the Initial Algebra Theorem from Chapter 6.

Well-founded coalgebras generalize well-foundedness for graphs, and they capture the induction principle for well-founded orders on an abstract level. Taylor’s General Recursion Theorem shows that, under hypotheses, every well-founded coalgebra is parametrically recursive. We give a new proof of this result, and we show that it holds for all set functors, and for all endofunctors preserving monomorphisms on a complete and well-powered category with smooth monomorphisms. The converse of the theorem holds for set functors preserving inverse images. We provide an iterative construction of the well-founded part of a given coalgebra: It is carried by the least fixed point of Jacobs’ next-time operator.

This chapter presents a number of sufficient conditions to guarantee that an endofunctor has an initial algebra or a terminal coalgebra. We generalize Kawahara and Mori’s notion of a bounded set functor and prove that for a cocomplete and co-well-powered category with a terminal object, every endofunctor bounded by a generating set has a terminal coalgebra. We use this to show that every accessible endofunctor on a locally presentable category has an initial algebra and a terminal coalgebra. We introduce pre-accessible functors and prove that on a cocomplete and co-well-powered category, the initial-algebra chain of a pre-accessible functor converges, and so the initial algebra exists. If the base category is locally presentable and the functor preserves monomorphisms, then the terminal coalgebra exists.

Hereditary cerebellar ataxia (HA) are a heterogeneous group of disorders characterized by the presence of slowly progressive gait ataxia, dysarthria and other cerebellar signs. Detailed clinical history and neurologic as well as systemic examination are key to accurate diagnosis and hierarchical diagnostic investigations. The initial diagnostic evaluation of patients with HA should include a detailed assessment to rule out acquired treatable etiologies. If such a detailed screening is inconclusive, investigations should be directed towards hereditary causes of cerebellar ataxias. Early diagnosis and treatment can lead to favorable outcomes. Disease-specific therapies have emerged for various cerebellar ataxia syndromes including hereditary ones. Despite these advances, management of the majority of HA remains symptomatic. Moreover, there are no US FDA-approved medications for HAs to date. However, there are a few progressive HA conditions that can improve with disease-specific treatment, particularly if initiated early in the disease course. Here, we discuss various hereditary cerebellar ataxia syndromes that are amenable to disease-specific/targeted treatment.

After their rescue from Egyptian slavery, the people of God journey for forty years in the desert, learning the hard lessons of relying on God amidst scarcity, with a place of worship at the center of the community.

Up to this point our concern has been how the ancient historian justifies himself before his audience and attempts to portray himself as the proper person for the writing of history, that is, with his role as narrator rerum. The present chapter examines how he approaches his task when a participant in the deeds he records, and how he reconciles the dual role of actor and auctor rerum. For many historians of the ancient world had the opportunity to be both participant and rememberer. The historian’s formal method of presenting himself has received comparatively little attention, yet it is of interest not only because it tells us something of the way that men who wrote history in the ancient world approached the writing of their own deeds, but also what their concerns were in doing so. It is usually assumed that in order to give authority to his account, an historian who narrated his own deeds used the third person and maintained a show of formal impartiality. But a study of the surviving (and partially surviving) historians reveals a variety of approaches and methods, changing with time, the specific type of history written, and the individual intention of the historian himself.

Tremor is clinically defined by an involuntary rhythmic oscillatory movement of a body part. The most recent 2-axis classification scheme describes a clinical tremor syndrome in axis 1, mainly relying on tremor characteristics (body distribution, activation condition, tremor frequency, regularity, amplitude) and associated signs (isolated versus combined tremor syndromes). Based on further diagnostic tests (blood analysis, imaging, neurophysiology, genetic testing) the etiology is then described in axis 2, which may be acquired, genetic or idiopathic. The most common axis 1 isolated tremor syndromes are essential tremor and enhanced physiologic tremor, characterized by bilateral action tremor of the arms. Combined tremor syndromes relate to the accompanying neurologic sign or are described phenomenologically. These tremor syndromes relate to hyperoscillatory states of distinct networks, with the so-called cerebellar network playing a central role. Depending on the degree of disturbance as well as the additional involvement of other networks, specific tremor phenotypes emerge.

Baptista and Sedlacek’s chapter takes Bickerton’s view that admixture is one of the chief characteristics of Creole languages (Bickerton 2008) as a starting point. The objective of their chapter is to bring to light the tight connections between the congruent forms observed across Creole languages (Faraclas et al. 2014; Faraclas 2012; Baptista 2006, 2009, 2020) which have been argued to result from speakers’ perception of similarities between the languages in contact and Weinreich’s notion of interlingual identification. A close review of interlingual identification (as it was laid out in Weinreich 1953) and how the concept has been applied and experimentally tested in situations of both bilingualism (Flege 1991) and multilingualism (Kresić and Gulan 2012) attest to how speakers use their native language as the mold through which they shape differently their interpretation of the same linguistic element in another language. As a result, the chapter argues that interlingual identification is ground zero for language mixing and language change.