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“What have we GANEd?” A theoretical construct to explain experimental evidence for noradrenergic regulation of sensory signal processing

Published online by Cambridge University Press:  05 January 2017

Rachel Navarra  and
Barry Waterhouse
Rachel Navarra
Affiliation:
Department of Cell Biology and Neuroscience, Rowan University School of Medicine, Stratford, NJ [email protected]@rowan.edu
Barry Waterhouse
Affiliation:
Department of Cell Biology and Neuroscience, Rowan University School of Medicine, Stratford, NJ [email protected]@rowan.edu
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Abstract

The GANE (glutamate amplifies noradrenergic effects) theory posits a mechanism for amplifying noradrenergic modulatory actions and enhancing the processing of high-priority sensory signals for immediate or future experience-guided action. This theoretical construct is thought provoking with respect to the central processing of high-priority versus low-priority stimuli, but it requires some refinement to account for physiological fluctuations in NE efflux as a function of naturally occurring transitions in behavioral state and the experimentally observed phenomena associated with noradrenergic regulation of sensory signal transfer.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 39 , 2016 , e219
Copyright
Copyright © Cambridge University Press 2016 

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References

Aston-Jones, G., Rajkowski, J. & Cohen, J. (1999) Role of locus coeruleus in attention and behavioral flexibility. Biological Psychiatry 46(9):1309–20.CrossRefGoogle ScholarPubMed
Berridge, C. W. & Abercrombie, E. D. (1999) Relationship between locus coeruleus discharge rates and rates of norepinephrine release within neocortex as assessed by in vivo microdialysis. Neuroscience 93:1263–70.CrossRefGoogle ScholarPubMed
Berridge, C. W. & Waterhouse, B. D. (2003) The locus coeruleus–noradrenergic system: Modulation of behavioral state and state-dependent cognitive processes. Brain Research Reviews 42(1):33–84. doi: 10.1016/s0165-0173(03)00143-7.Google Scholar
Cheun, J. E. & Yeh, H. H. (1992) Modulation of GABAA receptor-activated current by norepinephrine in cerebellar Purkinje cells. Neuroscience 51:951–60.Google Scholar
Devilbiss, D. M. & Waterhouse, B. D. (2000) Norepinephrine exhibits two distinct profiles of action on sensory cortical neuron responses to excitatory synaptic stimuli. Synapse 37(4):273–82.Google Scholar
Florin-Lechner, S. M., Druhan, J. P., Aston-Jones, G. & Valentino, R. J. (1996) Enhanced norepinephrine release in prefrontal cortex with burst stimulation of the locus coeruleus. Brain Research 742 (1/2):89–97.Google Scholar
Marrocco, R. T., Lane, R. F., McClurkin, J. W., Blaha, C. D. & Alkire, M. F. (1987) Release of cortical catecholamines by visual stimulation requires activity in thalamocortical afferents of monkey and cat. The Journal of Neuroscience 7:2756–67.Google Scholar
Moises, H. C., Waterhouse, B. D. & Woodward, D. J. (1983) Locus coeruleus stimulation potentiates local inhibitory processes in rat cerebellum. Brain Research Bulletin 10:795–804.CrossRefGoogle ScholarPubMed
Mouradian, R. D., Seller, F. M. & Waterhouse, B. D. (1991) Noradrenergic potentiation of excitatory transmitter action in cerebrocortical slices: Evidence of mediation by an alpha1-receptor-linked second messenger pathway. Brain Research 546:83–95.Google Scholar
Nai, Q., Dong, H. W., Linster, C. & Ennis, M. (2010) Activation of alpha1 and alpha2 noradrenergic receptors exert opposing effects on excitability of main olfactory bulb granule cells. Neuroscience 169:882–92.Google Scholar
Rajkowski, J., Majczynski, H., Clayton, E. & Aston-Jones, G. (2004) Activation of monkey locus coeruleus neurons varies with difficulty and performance in a target detection task. Journal of Neurophysiology 92(1):361–71.CrossRefGoogle Scholar
Rogawski, M. A. & Aghajanian, G. K. (1982) Activation of lateral geniculate neurons by locus coeruleus or dorsal noradrenergic bundle stimulation: Selective blockade by the alpha1-adrenoceptor antagonist prazosin. Brain Research 250:31–39.Google Scholar
Waterhouse, B. D., Azizi, S. A., Burne, R. A. & Woodward, D. J. (1990) Modulation of rat cortical area 17 neuronal responses to moving visual stimuli during norepinephrine and serotonin microiontophoresis. Brain Research 514:276–92.Google Scholar
Waterhouse, B. D., Moises, H. C., Yeh, H. H. & Woodward, D. J. (1982) Norepinephrine enhancement of inhibitory synaptic mechanisms in cerebellum and cerebral cortex: Mediation by beta adrenergic receptors. Journal of Pharmacology and Experimental Therapeutics 221:495–506.Google ScholarPubMed
Waterhouse, B. D., Sessler, F. M., Cheng, J. T., Woodward, D. J., Azizi, S. A. & Moises, H. C. (1988) New evidence for a gating action of norepinephrine in central neuronal circuits of mammalian brain. Brain Research Bulletin 21:425–32.Google Scholar