Hostname: page-component-78c5997874-v9fdk Total loading time: 0 Render date: 2024-11-05T04:20:49.245Z Has data issue: false hasContentIssue false
  • English
  • Français

“What have we GANEd?” A theoretical construct to explain experimental evidence for noradrenergic regulation of sensory signal processing

Published online by Cambridge University Press:  05 January 2017

Rachel Navarra  and
Barry Waterhouse
Rachel Navarra
Affiliation:
Department of Cell Biology and Neuroscience, Rowan University School of Medicine, Stratford, NJ [email protected]@rowan.edu
Barry Waterhouse
Affiliation:
Department of Cell Biology and Neuroscience, Rowan University School of Medicine, Stratford, NJ [email protected]@rowan.edu
Get access Rights & Permissions [Opens in a new window]

Abstract

The GANE (glutamate amplifies noradrenergic effects) theory posits a mechanism for amplifying noradrenergic modulatory actions and enhancing the processing of high-priority sensory signals for immediate or future experience-guided action. This theoretical construct is thought provoking with respect to the central processing of high-priority versus low-priority stimuli, but it requires some refinement to account for physiological fluctuations in NE efflux as a function of naturally occurring transitions in behavioral state and the experimentally observed phenomena associated with noradrenergic regulation of sensory signal transfer.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 39 , 2016 , e219
Copyright
Copyright © Cambridge University Press 2016 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Aston-Jones, G., Rajkowski, J. & Cohen, J. (1999) Role of locus coeruleus in attention and behavioral flexibility. Biological Psychiatry 46(9):1309–20.CrossRefGoogle ScholarPubMed
Berridge, C. W. & Abercrombie, E. D. (1999) Relationship between locus coeruleus discharge rates and rates of norepinephrine release within neocortex as assessed by in vivo microdialysis. Neuroscience 93:1263–70.CrossRefGoogle ScholarPubMed
Berridge, C. W. & Waterhouse, B. D. (2003) The locus coeruleus–noradrenergic system: Modulation of behavioral state and state-dependent cognitive processes. Brain Research Reviews 42(1):33–84. doi: 10.1016/s0165-0173(03)00143-7.Google Scholar
Cheun, J. E. & Yeh, H. H. (1992) Modulation of GABAA receptor-activated current by norepinephrine in cerebellar Purkinje cells. Neuroscience 51:951–60.Google Scholar
Devilbiss, D. M. & Waterhouse, B. D. (2000) Norepinephrine exhibits two distinct profiles of action on sensory cortical neuron responses to excitatory synaptic stimuli. Synapse 37(4):273–82.Google Scholar
Florin-Lechner, S. M., Druhan, J. P., Aston-Jones, G. & Valentino, R. J. (1996) Enhanced norepinephrine release in prefrontal cortex with burst stimulation of the locus coeruleus. Brain Research 742 (1/2):89–97.Google Scholar
Marrocco, R. T., Lane, R. F., McClurkin, J. W., Blaha, C. D. & Alkire, M. F. (1987) Release of cortical catecholamines by visual stimulation requires activity in thalamocortical afferents of monkey and cat. The Journal of Neuroscience 7:2756–67.Google Scholar
Moises, H. C., Waterhouse, B. D. & Woodward, D. J. (1983) Locus coeruleus stimulation potentiates local inhibitory processes in rat cerebellum. Brain Research Bulletin 10:795–804.CrossRefGoogle ScholarPubMed
Mouradian, R. D., Seller, F. M. & Waterhouse, B. D. (1991) Noradrenergic potentiation of excitatory transmitter action in cerebrocortical slices: Evidence of mediation by an alpha1-receptor-linked second messenger pathway. Brain Research 546:83–95.Google Scholar
Nai, Q., Dong, H. W., Linster, C. & Ennis, M. (2010) Activation of alpha1 and alpha2 noradrenergic receptors exert opposing effects on excitability of main olfactory bulb granule cells. Neuroscience 169:882–92.Google Scholar
Rajkowski, J., Majczynski, H., Clayton, E. & Aston-Jones, G. (2004) Activation of monkey locus coeruleus neurons varies with difficulty and performance in a target detection task. Journal of Neurophysiology 92(1):361–71.CrossRefGoogle Scholar
Rogawski, M. A. & Aghajanian, G. K. (1982) Activation of lateral geniculate neurons by locus coeruleus or dorsal noradrenergic bundle stimulation: Selective blockade by the alpha1-adrenoceptor antagonist prazosin. Brain Research 250:31–39.Google Scholar
Waterhouse, B. D., Azizi, S. A., Burne, R. A. & Woodward, D. J. (1990) Modulation of rat cortical area 17 neuronal responses to moving visual stimuli during norepinephrine and serotonin microiontophoresis. Brain Research 514:276–92.Google Scholar
Waterhouse, B. D., Moises, H. C., Yeh, H. H. & Woodward, D. J. (1982) Norepinephrine enhancement of inhibitory synaptic mechanisms in cerebellum and cerebral cortex: Mediation by beta adrenergic receptors. Journal of Pharmacology and Experimental Therapeutics 221:495–506.Google ScholarPubMed
Waterhouse, B. D., Sessler, F. M., Cheng, J. T., Woodward, D. J., Azizi, S. A. & Moises, H. C. (1988) New evidence for a gating action of norepinephrine in central neuronal circuits of mammalian brain. Brain Research Bulletin 21:425–32.Google Scholar