Although the notion of God as the legislator of nature was already known in the Jewish-Christian tradition, the modern concept of laws of nature was established only in the seventeenth-century mechanical philosophy of nature, particularly by Descartes and Newton, and remained largely confined to that tradition before it became seriously questioned in quantum mechanics. After a brief historical survey, I first discuss various examples of so-called laws of nature in chemistry and physical chemistry proposed in the nineteenth century to conclude that none of them really correspond to the original concept, but that they rather comprise a variety of epistemologically different statements. More recent philosophical approaches to extend the concept of laws, so as to cover chemical cases, all result in inacceptable consequences. The deeper reason of the comparatively little importance of natural laws, I finally argue, is that chemistry as the original epitome of the experimental or Baconian science has largely followed methodological pluralism in which a variety of models to be chosen from for pragmatic reasons are preferred over universal laws of nature as in mathematical physics.