Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis

doi:10.1017/CBO9780511545313

Human Herpesviruses

Biology, Therapy, and Immunoprophylaxis

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This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

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Page 3 of 4

Contents

49 - HHV-6A, 6B, and 7: persistence in the population: epidemiology and transmission
pp 875-882
- By Vincent C. Emery, Department of Virology, Royal Free and University College Medical School of UCL, London, UK, Duncan A. Clark, Department of Virology, Royal Free and University College Medical School of UCL, London, UK
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Part III - Pathogenesis, clinical disease, host response, and epidemiology: gammaherpesviruses
pp 883-884
- By Patrick S. Moore, Molecular Virology Program, University of Pittsburgh Cancer Institute
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50 - Clinical and pathological aspects of EBV And KSHV infection
pp 885-903
- By Richard F. Ambinder, Johns Hopkins School of Medicine Departments of Oncology, Pathology, and Pharmacology Baltimore, MD, USA, Ethel Cesarman, Weill Medical College of Cornell University Department of Pathology and Laboratory Medicine New York, NY, USA
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51 - EBV: Immunobiology and host response
pp 904-914
- By Denis J. Moss, Infectious Disease and Immunology Division, Queensland Institute of Medical Research and Joint Oncology Program, University of Queensland, Australia, Scott R. Burrows, Infectious Disease and Immunology Division, Queensland Institute of Medical Research and Joint Oncology Program, University of Queensland, Australia, Rajiv Khanna, Infectious Disease and Immunology Division, Queensland Institute of Medical Research and Joint Oncology Program, University of Queensland, Australia
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52 - Immunobiology and host response to KSHV infection
pp 915-928
- By Dimitrios Lagos, Cancer Research UK Viral Oncology Group, Wolfson Institute for Biomedical Research, University College London, London, UK, Chris Boshoff, Cancer Research UK Viral Oncology Group, Wolfson Institute for Biomedical Research, University College London, London, UK
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53 - The epidemiology of EBV and its association with malignant disease
pp 929-959
- By Henrik Hjalgrim, Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S. Denmark, Jeppe Friborg, Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S. Denmark, Mads Melbye, Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S. Denmark
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54 - The epidemiology of KSHV and its association with malignant disease
pp 960-985
- By Jeffrey N. Martin, Department of Epidemiology and Biostatistics, University of California, San Francisco, 185 Berry Street, Suite 5700 San Francisco, CA, USA
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55 - EBV-induced oncogenesis
pp 986-1006
- By Nancy Raab-Traub, Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, USA
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56 - KSHV-induced oncogenesis
pp 1007-1028
- By Donald Ganem, Howard Hughes Medical Institute, Departments of Microbiology and Immunology and Medicine, University of California, San Francisco, CA, USA
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Part IV - Non-human primate herpesviruses
pp 1029-1030
- By Ann Arvin, Department of Pediatrics and Microbiology and Immunology, Stanford University School of Medicine, Patrick Moore, Molecular Virology Program, University of Pittsburgh Cancer Institute Hillman Cancer Center, Richard Whitley, Department of Pediatrics, University of Alabama at Birmingham
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57 - Monkey B virus
pp 1031-1042
- By Julia Hilliard, Department of Biology, Georgia State University, Atlanta, GA, USA
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58 - Simian varicella virus
pp 1043-1050
- By Ravi Mahalingam, Departments of Neurology, University of Colorado Health Sciences Center, Denver, CO, USA, Donald H. Gilden, Microbiology, University of Colorado Health Sciences Center, Denver, CO, USA
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59 - Primate betaherpesviruses
pp 1051-1075
- By Peter A. Barry, Center for Comparative Medicine, W. L. William Chang, Center for Comparative Medicine
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60 - Gammaherpesviruses of New World primates
pp 1076-1092
- By Bernhard Fleckenstein, Institut für Klinische und Molekulare Virologie Erlangen, Germany, Armin Ensser, Institut für Klinische und Molekulare Virologie Erlangen, Germany
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61 - EBV and KSHV-related herpesviruses in non-human primates
pp 1093-1114
- By Blossom Damania, Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina, NC, USA
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Part V - Subversion of adaptive immunity
pp 1115-1116
- By Richard Whitley, Department of Pediatrics, University of Alabama at Birmingham, Ann Arvin, Department of Pediatrics and Microbiology and Immunology, Stanford University School of Medicine
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62 - Herpesvirus evasion of T-cell immunity
pp 1117-1136
- By Benjamin E. Gewurz, Department of Pathology, Harvard Medical School, Boston, MA, USA, Jatin M. Vyas, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA, Hidde L. Ploegh, Department of Pathology, Harvard Medical School, Boston, MA, USA
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63 - Subversion of innate and adaptive immunity: immune evasion from antibody and complement
pp 1137-1150
- By Lauren M. Hook, Department of Medicine, University of Pennsylvania School of Medicine, PA, USA, Harvey M. Friedman, Department of Medicine, University of Pennsylvania School of Medicine, PA, USA
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Part VI - Antiviral therapy
pp 1151-1152
- By Ann Arvin, Department of Pediatrics and Microbiology and Immunology, Stanford University School of Medicine, Richard Whitley, Department of Pediatrics, University of Alabama at Birmingham
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64 - Antiviral therapy of HSV-1 and -2
pp 1153-1174
- By David W. Kimberlin, Department of Pediatrics, University of Alabama at Birmingham, AL, USA, Richard J. Whitley, Department of Pediatrics, University of Alabama at Birmingham, AL, USA
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65 - Antiviral therapy of varicella-zoster virus infections
pp 1175-1191
- By John W. Gnann, Jr., Departments of Medicine, Pediatrics and Microbiology, Division of Infectious Diseases, University of Alabama at Birmingham and the Birmingham VA Medical Center Birmingham, AL, USA
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66 - Antiviral therapy for human cytomegalovirus
pp 1192-1210
- By Paul D. Griffiths, Royal Free and University College Medical School, London, UK, Michael Boeckh, Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
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67 - New approaches to antiviral drug discovery (genomics/proteomics)
pp 1211-1218
- By Mark N. Prichard, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA
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68 - Candidate anti-herpesviral drugs; mechanisms of action and resistance
pp 1219-1250
- By Karen K. Biron, Clinical Virology, GlaxoSmithKline, Research Triangle Park, NC, USA
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Part VII - Vaccines and immunothgerapy
pp 1251-1252
- By Ann Arvin, Department of Pediatrics and Microbiology and Immunology, Stanford University School of Medicine, Koichi Yamanishi, Department of Microbiology, Osaka University School of Medicine
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69 - Herpes simplex vaccines
pp 1253-1261
- By George Kemble, MedImmune Vaccines, Inc., Mountain View, CA, USA, Richard Spaete, MedImmune Vaccines, Inc., Mountain View, CA, USA
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70 - Varicella-zoster vaccine
pp 1262-1273
- By Anne A. Gershon, Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY, USA
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71 - Human cytomegalovirus vaccines
pp 1274-1291
- By Thomas C. Heineman, Division of Infectious Diseases and Immunology Saint Louis University School of Medicine, Missouri, USA
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72 - Epstein–Barr virus vaccines
pp 1292-1305
- By Andrew J. Morgan, Division of Virology, Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, UK, Rajiv Khanna, Tumour Immunology Laboratory, Division of Infectious Diseases and Immunology, Queensland Institute for Medical Research, Herston, Australia
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73 - DNA vaccines for humanherpesviruses
pp 1306-1317
- By Thomas G. Evans, Vical Incorporated, San Diego, CA, USA, Mary Wloch, Vical Incorporated, San Diego, CA, USA
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Human Herpesviruses

Biology, Therapy, and Immunoprophylaxis

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