Far-infrared (FIR) analysis of synthetic Mg-, Ni-, Co-, and Fe-phlogopites coupled with structural data from X-ray diffraction revealed that the K interlayer environments are directly related to octahedral sheet composition and geometry. The general phlogopite formula, KM32+(Si3Al)O10(OH)2, was varied according to octahedral compositions, where M2+ = Mg2+, Fe2+, Co2+, and Ni2+. Octahedral substitutions have a direct effect on the b lattice parameter, which is related to the tetrahedral-octahedral sheet misfit and manifested by change in the tetrahedral rotation angle (α). The ditrigonal interlayer cavity geometry and the potential for retention of the compensating cations therefore varies according to the ionic size and the types and oxidation state of octahedral cations. These structural features appear as frequency shifts on FIR spectra. When Mg2+ is replaced by a smaller cation, Ni2+, the b parameter decreases and the tetrahedral rotation angle, α, increases, inducing the collapse of the ditrigonal ring. When this happens, the local anisotropy of the interlayer site increases, resulting in every other six out of 12 K-O bonds becoming shorter and the in-plane K-O vibration band shifts slightly to greater wavenumbers. Synthetic phlogopites with octahedral substitutions by cations of larger ionic radii (i.e. Co2+ and Fe2+) exhibit b parameter increases, where in the case of the annite end-member, α decreases to almost 0°. As α decreases, compensating cation sites become more hexagonal like and the nearest K-O bond increases in length. The K-O vibration bands move toward much smaller wavenumbers. Far infrared offers the potential for a new approach to study the retention of interlayer cations in other phyllosilicates and the mechanisms by which they are altered, such as heating or by weathering reactions in the environment.

In this paper, we first introduce a simulator of cases estimates of incurred losses called SPLICE (Synthetic Paid Loss and Incurred Cost Experience). In three modules, case estimates are simulated in continuous time, and a record is output for each individual claim. Revisions for the case estimates are also simulated as a sequence over the lifetime of the claim in a number of different situations. Furthermore, some dependencies in relation to case estimates of incurred losses are incorporated, particularly recognising certain properties of case estimates that are found in practice. For example, the magnitude of revisions depends on ultimate claim size, as does the distribution of the revisions over time. Some of these revisions occur in response to occurrence of claim payments, and so SPLICE requires input of simulated per-claim payment histories. The claim data can be summarised by accident and payment “periods” whose duration is an arbitrary choice (e.g. month, quarter, etc.) available to the user. SPLICE is built on an existing simulator of individual claim experience called SynthETIC (introduced in Avanzi et al. 2021b, Insurance: Mathematics and Economics, 100, 296–308), which offers flexible modelling of occurrence, notification, as well as the timing and magnitude of individual partial payments. This is in contrast with the incurred losses, which constitute the additional contribution of SPLICE. The inclusion of incurred loss estimates provides a facility that almost no other simulators do. SPLICE is is a fully documented R package that is publicly available and open source (on CRAN). SPLICE, combined with SynthETIC, provides 11 modules (occurrence, notification, etc.), any one or more of which may be re-designed according to the user’s requirements. It comes with a default version that is loosely calibrated to resemble a specific (but anonymous) Auto Bodily Injury portfolio, as well as data generation functionality that outputs alternative data sets under a range of hypothetical scenarios differing in complexity. The general structure is suitable for most lines of business, with some reparameterisation.

Bio-composite materials with optimal mechanical and structural properties and capability of cell differentiation are crucial for tissue engineering. Synthetic collagen proteins with lengths of approximately 10 nanometers, along with natural spider silk proteins provide an opportunity for development of an optimal biomaterial for scaffolding applications in tissue engineering. This combines unique mechanical, structural and biological properties of two of the nature’s best polymer proteins, albeit the collagen used in the present work is of the synthetic nature, it mimics the properties and advantages of natural collagen itself. In the present work, we study the binding capability of these proteins at a molecular level via molecular dynamics modeling. Spider silk and synthetic collagen protein molecular models in biophysical saline conditions under standard pressure and temperature are investigated to understand if natural binding occurs between the two without any other external factors. An initial minimum separation of 10 angstroms between the proteins was used. Binding was observed between the two proteins throughout the dynamic simulation of 100 nanoseconds. The radius of gyration and minimum distance between the proteins shows a decreasing separation between the two proteins until a stable distance of 2.5 nanometers and 0.2 nanometers respectively, is achieved. Binding is further observed between the proteins via formation of strong and stable hydrogen bonds. A hydrogen bond between collagen Proline-31 and silk Serine-96 was observed to be the most stable and frequent bond between the single collagen and silk system. Results clearly indicate a self-assembly behavior of these two systems illustrating their potential as a biomaterial for tissue engineering.

Numerous fabrication protocols are known to yield transition metal oxides with structures related to layered double hydroxides, but the effect of fabrication protocol on the uniformity of mixed-metal compositions remain largely unexplored. We have analysed the apparent solubility limits and the structural implications of iron ions in nickel hydroxide lattices for materials prepared by four different fabrication protocols. Opposing shifts in the (100) and (001) reflection in powder X-ray diffraction results revealed a contraction of the nickel lattice upon successful incorporation of iron, with Ni-M distances exhibiting an apparently linear decrease with respect to iron content. This feature revealed the amount of iron incorporated into nickel-based materials to be dependent on fabrication protocol, varying from apparently negligible concentrations to over fifty atomic percent. The dependency of structure on fabrication protocols provides a handle to improve fundamental understanding of catalytically relevant coordination environments.

Synthesis and characterization of cassava bark nanoparticles (CBNPs) was carried out using ball milling at 36, 48, 60 and 72 hours. The morphology study was done using SEM and the Gwyddion software was used to determine the particle sizes from the SEM images. The particle distribution for the un-milled cassava bark (CB) was between 1.25 + 0.06 to 19.92 + 1.00 µm, while after milling for 36, 48, 60 and 72 hours the average particle size were 4.07 + 0.20, 4.00 + 0.20 µm, 80.90 + 4.05, 74.50 + 3.73 nm respectively. 13.68 + 0.68 nm was obtained by XRD using Scherrer equation after milling for 72 hours and the XRD results revealed the presence of compounds such as SiO2, CaCO3 and KAlSi3O8. TEM was used to determine nanoparticle size distribution after milling for 72 hours and the particle size ranged from 9.73 + 0.49 to 114.60 + 5.73 nm for cassava bark nanoparticles (CBNPs), EDX results showed trace element of Si, Ca, K, Fe, Al, O in the CB milled for 72hours.

A new family of six ionenes containing aromatic amide linkages has been synthesized from ready available starting materials at scales up to ∼50 g. These ionene-polyamides are all constitutional isomers and vary only in the regiochemistry of the amide linkages (para, meta) and xylyl linkages (ortho, meta, para) which are present in the polymer backbone. This paper details the synthesis of these ionenes and associated characterizations. Ionene-polyamides exhibit relatively low melting points (∼150 oC) allowing them to be readily processed into films and other objects. These ionene-polyamide materials are being developed for further study as polymer membranes for the separations of gases such as CO2, N2, CH4 and H2.

Vitamin D has become one of the most discussed nutrients in human nutrition, which has led to an increased interest in milk as a vitamin D source. Problems related to fortifying milk with synthetic vitamin D can be avoided by securing a high content of natural vitamin D in the milk by supplying dairy cows with sufficient vitamin D. However, choosing the most efficient route and form of supplementation requires insight into how different vitamin D metabolites are transported in the body of cattle. There are two forms of vitamin D: vitamin D2 (D2) and vitamin D3 (D3). Vitamin D2 originates from fungi on roughage. Vitamin D3 originates either from endogenous synthesis in the skin or from feed supplements. Vitamin D2 is chemically different from, and less physiologically active than, D3. Endogenous and dietary D3 is chemically similar but dietary D3 is toxic, whereas endogenous D3 appears well regulated in the body.

The aim of this study was to compare the effects of supplementing dairy cows with 1000 IU/day of all-rac-α-tocopheryl acetate (SynAc), RRR-α-tocopheryl acetate (NatAc), or RRR-α-tocopherol (NatAlc), from approximately 3 weeks before estimated calving until 2 weeks after calving, on the concentration of α-tocopherol and its stereoisomers (RRR-, RSS-, RRS-, RSR- and the four 2S-forms of α-tocopherol) in blood and milk. An unsupplemented group was included as control. Blood samples were collected at 3, 2 and 1 weeks before estimated calving, at calving, and 3, 7 and 14 days after calving, while milk samples were taken twice within 24 h after calving and at 7 and 14 days in milk. Overall, time and treatment had significant effects on plasma α-tocopherol with higher concentrations in NatAc than in the other groups. In addition, SynAc had higher concentrations than Control, and NatAlc tended to be higher than Control. The lowest plasma concentrations were observed at calving and 3 days after calving. Independent of treatment, the concentration was higher in colostrum than in milk day 7 and 14 after calving. Analyses of the stereoisomer distribution in plasma and milk showed that, irrespective of dietary treatment, RRR-α-tocopherol was the most predominant form, constituting more than 86%, whereas the remaining part of α-tocopherol was made up by the three synthetic 2R isomers, while the 2S isomers only contributed less than 1% of the total α-tocopherol. In control cows and cows supplemented with natural vitamin E, the proportion of RRR-α-tocopherol in plasma and milk constituted more than 98% of the total α-tocopherol. In conclusion, the results indicate that daily oral supplementation of dairy cows with RRR-α-tocopheryl acetate gives the highest blood concentrations of α-tocopherol in the periparturient period. Analyses of the distribution of the individual stereoisomers of α-tocopherol further indicate that the bioavailability of RRR-α-tocopherol relative to synthetic stereoisomers in cattle is considerably higher than officially accepted until now.

L'article applique à la micro-économie une distinction classique en philosophie du langage, celle des propositions analytiques et synthétiques. Un article ultérieur la rapprochera de la distinction épistémologique des connaissances a priori et a posteriori. On commence par reprendre les définitions principales de l'analytique et du synthétique, et l'on rejette les objections célèbres que Quine a dirigées contre elles. On montre ensuite comment ces définitions opèrent sur la théorie des biens Giffen et des biens substituts. La distinction de l'analytique et du synthétique permet de clarifier des options que les micro-économistes laissent implicites, au risque de tomber dans des pièges sémantiques; en l'occurrence, elle vient renforcer la critique déjà faite de la définition hicksienne des substituts. A titre annexe, on montre que la méthodologie économique identifie incorrectement les propositions analytiques aux tautologies, et les propositions synthétiques à celles qui sont testables.

Perioperative acute right heart failure after orthotopic heart transplantation contributes significantly to morbidity and mortality. Vasodilators administered intravenously may decrease pulmonary vascular resistance, but also affect systemic circulation. A decrease of mean arterial pressure will result in reduced right coronary blood flow and deterioration of right ventricular performance. Vasodilators administered by inhalation, i.e. nitric oxide and prostacyclin, are attractive due to a more selective effect on the pulmonary circulation. This is the first report on the use of aerosolized iloprost, a long-acting prostacyclin analogue, applied for treatment of postoperative right heart failure in cardiac transplantation. After uneventful surgery, a heart transplant recipient was extubated on the first postoperative day and exhibited right heart failure on the following day. Standard treatment did not resolve this clinical problem sufficiently. A trial with inhalation of iloprost (16 μg per inhalation cycle, applied six times per day) was initiated. Iloprost inhalation resulted in a sufficient decrease of pulmonary vascular resistance (–23.5%), while cardiac index (+24.0%) and mixed venous saturation (+9.0%) increased. No profound effect on the systemic vascular resistance was observed (−2.8%). Iloprost inhalation may be an effective alternative to nitric oxide in the intensive care management of acute right heart failure after orthotopic heart transplantation. Due to the prolonged effect on the pulmonary vascular resistance, iloprost is especially useful for extubated patients.

The efficacy of parenteral nutrition could be improved by finding a more effective energy source. Esters of short-chain fatty acids have exhibited some promise as alternatives to glucose. The present study reports on two new esters and one amide, each containing acetoacetate as the organic acid. The three compounds: glyceryl bisacetoacetate, N-2',3'-dihydroxypropyl-3-oxo-butanamide (1-acetoacetamido-2,3-propane diol), and partially reduced glucosyl pentaacetoacetate, were synthesized and then continuously infused into rats for 7d. The infusion rate provided 50% of the rats' estimated metabolic energy requirement, and rats were fed with a reduced-energy oral diet that provided the remaining 50% of energy plus adequate protein. Rat groups for each compound were: (1) experimental-compound-infused and ad libitum-fed, (2) isoenergetic glucose-infused and pairfed, and (3) saline infused and pair-fed. Body-weight changes, N losses and N retention were measured daily. All rats died from partially reduced glucosyl pentaacetoacetate infusion at 100% and 50% of the intended rate. Rats infused with l-acetoacetamido-2,3-propane diol failed to gain weight and to increase the plasma ketone-body concentration. Glyceryl bisacetoacetate produced hyperketonaemia, and weight gain and N variables that were similar to those for glucose-infused rats. It was concluded that only glyceryl bisacetoacetate would make a satisfactory parenteral nutrient.