Hostname: page-component-78c5997874-xbtfd Total loading time: 0 Render date: 2024-11-12T20:05:22.330Z Has data issue: false hasContentIssue false
  • English
  • Français

A call for mapping the development of the microbiota-gut-brain axis during human infancy

Published online by Cambridge University Press:  15 July 2019

Caroline Malory Kelsey Open the ORCID record for Caroline Malory Kelsey [Opens in a new window]  and
Tobias Grossmann Open the ORCID record for Tobias Grossmann [Opens in a new window]
Caroline Malory Kelsey
Affiliation:
Psychology Department, University of Virginia, Charlottesville, VA 22903. [email protected]@virginia.eduwww.uvababylab.org
Tobias Grossmann
Affiliation:
Psychology Department, University of Virginia, Charlottesville, VA 22903. [email protected]@virginia.eduwww.uvababylab.org
Get access Rights & Permissions [Opens in a new window]

Abstract

We argue for the importance of looking at the microbiota-gut-brain axis from a human developmental perspective. For this purpose, we first briefly highlight emerging research with infants attesting that the microbiome plays a role in early brain and cognitive development. We then discuss the use of developmentally informed humanized mouse models and implications of microbiome research that go beyond probiotic administration.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 42 , 2019 , e74
Check for updates
Copyright
Copyright © Cambridge University Press 2019 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Abrahamsson, T., Jakobsson, H., Andersson, A. F., Björkstén, B., Engstrand, L. & Jenmalm, M. (2014) Low gut microbiota diversity in early infancy precedes asthma at school age. Clinical & Experimental Allergy 44(6):842–50. Available at: https://doi.org/10.1111/cea.12253.Google Scholar
Borre, Y. E., O'Keeffe, G. W., Clarke, G., Stanton, C., Dinan, T. G. & Cryan, J. F. (2014) Microbiota and neurodevelopmental windows: Implications for brain disorders. Trends in Molecular Medicine 20(9):509–18. Available at: https://doi.org/10.1016/j.molmed.2014.05.002.Google Scholar
Carlson, A. L., Xia, K., Azcarate-Peril, M. A., Goldman, B. D., Ahn, M., Styner, M. A., Thompson, A. L., Geng, X., Gilmore, J. H. & Knickmeyer, R. C. (2018) Infant gut microbiome associated with cognitive development. Biological Psychiatry 83(2):148–59. Available at: https://doi.org/10.1016/j.biopsych.2017.06.021.Google Scholar
Curran, E. A., O'Neill, S. M., Cryan, J. F., Kenny, L. C., Dinan, T. G., Khashan, A. S. & Kearney, P. M. (2015) Research review: Birth by caesarean section and development of autism spectrum disorder and attention-deficit/hyperactivity disorder: A systematic review and meta-analysis. Journal of Child Psychology and Psychiatry 56(5):500–508. Available at: https://doi.org/10.1111/jcpp.12351.Google Scholar
Dominguez-Bello, M. G., Costello, E. K., Contreras, M., Magris, M., Hidalgo, G., Fierer, N. & Knight, R. (2010) Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proceedings of the National Academy of Sciences USA 107(26):11971–75. Available at: https://doi.org/10.1073/pnas.1002601107.Google Scholar
Heikkilä, M. & Saris, P. (2003) Inhibition of Staphylococcus aureus by the commensal bacteria of human milk. Journal of Applied Microbiology 95(3):471–78. Available at: https://doi.org/10.1046/j.1365-2672.2003.02002.x.Google Scholar
Kelsey, C., Dreisbach, C., Alhusen, J. & Grossmann, T. (2019) A primer on investigating the role of the microbiome in brain and cognitive development. Developmental Psychobiology. First published online October 12, 2018. Available at: https://doi.org/10.1002/dev.21778.Google Scholar
Kostic, A. D., Gevers, D., Siljander, H., Vatanen, T., Hyötyläinen, T., Hämäläinen, A.-M., Peet, A., Tillmann, V., Pöhö, P., Mattila, I., Lähdesmäki, H., Franzosa, E. A., Vaarala, O., de Goffau, M., Harmsen, H., Ilonen, J., Virtanen, S. M., Clish, C. B., Orešič, M., Huttenhower, C., Knip, N., on behalf of the DIABIMMUNE Study Group & Xavier, R. J. (2015) The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes. Cell Host & Microbe 17(2):260–73. Available at: https://doi.org/10.1016/j.chom.2015.01.001.Google Scholar
Krol, K. M. & Grossmann, T. (2018) Psychological effects of breastfeeding on children and mothers. Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 61(8):977–85. Available at: https://doi.org/10.1007/s00103-018-2769-0.Google Scholar
Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X.-N., Kubo, C. & Koga, Y. (2004) Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice. Journal of Physiology 558(1):263–75. Available at: https://doi.org/10.1113/jphysiol.2004.063388.Google Scholar
Walker, W. A. (2013) Initial intestinal colonization in the human infant and immune homeostasis. Annals of Nutrition and Metabolism 63(S2):8–15. Available at: https://doi.org/10.1159/000354907.Google Scholar
Walsh, N. C., Kenney, L. L., Jangalwe, S., Aryee, K. E., Greiner, D. L., Brehm, M. A. & Shultz, L. D. (2017) Humanized mouse models of clinical disease. Annual Review of Pathology 12:187–215. Available at: https://doi.org/10.1146/annurev-pathol-052016-100332.Google Scholar