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Inter-individual variation shapes the human microbiome

Published online by Cambridge University Press:  15 July 2019

Emily F. Wissel
Affiliation:
Emory University School of Nursing, Wesley Woods Hospital, Atlanta, GA 30329. [email protected]
Leigh K. Smith
Affiliation:
Department of Psychology, University of California at Davis, Davis, CA 95616. [email protected]

Abstract

The target article suggests inter-individual variability is a weakness of microbiota-gut-brain (MGB) research, but we discuss why it is actually a strength. We comment on how accounting for individual differences can help researchers systematically understand the observed variance in microbiota composition, interpret null findings, and potentially improve the efficacy of therapeutic treatments in future clinical microbiome research.

Type
Open Peer Commentary
Copyright
Copyright © Cambridge University Press 2019 

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References

Benton, D., Williams, C. & Brown, A. (2007) Impact of consuming a milk drink containing a probiotic on mood and cognition. European Journal of Clinical Nutrition 61(3):355–61. Available at: https://www.nature.com/articles/1602546.Google Scholar
Bercik, P., Park, A. J., Sinclair, D., Khoshdel, A., Lu, J., Huang, X., Deng, Y., Blennerhassett, P. A., Fahnestock, M., Moine, D., Berger, B., Huizinga, J. D., Kunze, W., McLean, P. G., Bergonzelli, G. E., Collins, S. M. & Verdu, E. F. (2011b) The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication. Neurogastroenterology and Motility 23:1132–39. Available at: https://doi.org/10.1111/j.1365-2982.2011.01796.x.Google Scholar
Clarke, G., Grenham, S., Scully, P., Fitzgerald, P., Moloney, R. D., Shanahan, F., Dinan, T. G. & Cryan, J. F. (2013) The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Molecular Psychiatry 18(6):666–73. Available at: https://doi.org/10.1038/mp.2012.77.Google Scholar
Dill-McFarland, K., Tang, Z.-Z., Kemis, J., Kerby, R., Chen, G., Palloni, A., Sorenson, T., Rey, F. & Herd, P. (2019) Close social relationships correlate with human gut microbiota composition. Scientific Reports 9(1):703. Available at: https://doi.org/10.1038/s41698-018-37298-9.Google Scholar
Falony, G., Joossens, M., Vieira-Silva, S., Wang, J., Darzi, Y., Faust, K., Kurilshikov, A., Bonder, M. J., Valles-Colomer, M., Vandeputte, D., Tito, R. Y., Chaffron, S., Rymenans, L., Verspecht, C., De Sutter, L., Lima-Mendez, G., D'Hoe, K., Jonckheere, K., Homola, D., Garcia, R., Tigchelaar, E. F., Eeckhaudt, L., Fu, J., Henckaerts, L., Zhernakova, A., Wijmenga, C. & Raes, J. (2016) Population-level analysis of gut microbiome variation. Science 352(6285):560–64. Available at: https://doi.org/10.1126/science.aad3503.Google Scholar
Jadhav, K. S., Peterson, V. L., Halfon, O., Ahern, G., Fouhy, F., Stanton, C., Dinan, T. G., Cryan, J. F., & Boutrel, B. (2018) Gut microbiome correlates with altered striatal dopamine receptor expression in a model of compulsive alcohol seeking. Neuropharmacology 141:249–59. Available at: https://doi.org/10.1016/j.neuropharm.2018.08.026.Google Scholar
Liu, R. T. (2017) The microbiome as a novel paradigm in studying stress and mental health. American Psychologist 72(7):655–67. Available at: https://doi.org/10.1037/amp0000058.Google Scholar
Wissel, E. F. & Smith, L. K. (2019) Microbes and the mind: How bacteria shape affect, neurological processes, cognition, social relationships, development, and pathology. Perspectives on Psychological Science. Available at: https://doi.org/10.1177/1745691618809379.Google Scholar