The role of religiosity as an important predictor of partisan identification has been well researched over the years, with most of our understanding of religion focused on Christianity. However, it is not clear that religiosity operates equally for the partisan identification of non-Christian religious groups. One of the most discussed religious minority groups in the United States today is Muslim-Americans. Numbering between 2.3 million and 7 million, Muslim-Americans have been the focus of considerable debate regarding religion and American political inclusion. We argue that religiosity does influence Muslim-American party identification, however not in the same manner as with other groups. While the two major political parties encourage religiosity among Protestants, Jews, and Catholics, they are either silent or opposed to religiosity among Muslims within their parties. Thus, religiosity among Muslim-Americans may not necessarily lead to partisan identification with either Republicans or Democrats. Rather, high levels of religiosity, coupled with perceptions of discrimination against Muslims, may lead many to oppose both major political parties and instead identify with “none of the above.” This is not to say that Muslim-Americans reject civic engagement or political participation in the United States, but rather the two political parties have not carved out a space to welcome Islam, as they have for Christianity and Judaism. We examine new data from the 2007 Muslim-American Public Opinion Survey to assess the predictors of partisan identification among Muslims in the United States.