This paper reports the methods and preliminary findings of Germina, an ongoing cohort study to identify biomarkers and trajectories of executive functions and language development in the first 3 years of life. 557 mother-infant dyads (mean age of mothers 33.7 years, 65.2% white, 48.7% male infants) have undergone baseline and are currently collecting data for other timepoints. A linear regression was used to predict baseline Bayley-III using scores derived from data-driven sparse partial least squares utilizing a multiple holdout framework of 15 domains. Significant associations were found between socioeconomic/demographic characteristics (B = 0.29), epigenetics (B = 0.11), EEG theta (B = 0.14) and beta activity (B = 0.11), and microbiome functional pathways (B = 0.08) domains, and infant development measured by the Bayley-III at T1, suggesting potential interventions to prevent impairments.

Childhood maltreatment, a significant distal risk factor for individual development, is potentially linked to maladaptive cognitive emotion regulation strategies (MCERS) and increased internalizing problems (i.e., depression and anxiety). Prior research has widely identified that MCERS mediate the link between childhood maltreatment and internalizing problems. However, this result overlooks the potential bidirectional relationship between MCERS and internalizing problems. In this study, we aim to explore whether childhood maltreatment longitudinally linked to internalizing problems through the mediating role of MCERS, or, conversely, was related to subsequent MCERS through internalizing problems. Gender differences in the associations between these variables were also examined. Participants were 892 adolescents from a longitudinal design with two waves (487 females, 405 males; Mage = 15.36, SDage = 1.43). Our results indicated that childhood maltreatment was longitudinally related to MCERS and internalizing problems. T1 MCERS mediated the relationship between T1 child maltreatment and T2 internalizing problems, while T1 internalizing problems also played a mediating role between T1 child maltreatment and T2 MCERS. These findings were also equivalent across genders. Taken together, childhood maltreatment was longitudinally associated with internalizing problems through MCERS, and also related to subsequent MCERS through internalizing problems.

Children and adolescents display varying trajectories of conduct problems (CP), but it is unclear if these CP trajectories can be distinguished by childhood antecedents and adolescent outcomes. Therefore, we tested if child- and environmental-level risk factors predict CP trajectory membership and if CP trajectories are associated with developmental outcomes in adolescence. Six waves of data (teacher-, parent- and child self-reports) were used from 2,045 children. General growth mixture modeling identified four CP trajectories (waves 2–5): childhood-persistent, childhood-limited, adolescent-onset, and low CP. Relative to the adolescent-onset CP trajectory, wave 1 child- and environmental-level risk factors increased the likelihood of being in the childhood-persistent CP trajectory, though all but two (callous-unemotional traits and non-intact family) antecedents lost significance after controlling for wave 1 conduct problems. Few significant differences emerged in risk factors when comparing childhood-persistent and childhood-limited CP trajectories. Individuals identified in the adolescent-onset and childhood-persistent CP trajectories faced a higher risk for later maladjustment than those in the childhood-limited CP trajectory, whereas the adolescent-onset and childhood-persistent CP trajectories only differed in three out of 13 outcomes. Overall, findings indicate that individuals with CP are at risk for later maladjustment, but predicting the childhood-persistent trajectory of CP in young children is difficult.

Co-occurring autism and attention-deficit/hyperactivity disorder (ADHD) have been associated with poorer social skills. Most studies examining the association of ADHD symptoms and social skills in autism employ categorical and cross-sectional designs, which provide a narrow view of the development of ADHD symptoms. Using group-based trajectory modeling, we identified five trajectories of caregiver-reported attention problems in an inception cohort of autistic children (N = 393) followed from age 2–5 years (T1) to age 10.5–11 years (T8): Low-Stable (LS; 15.5% of participants), Low-Decreasing (LD; 25.2%), Low-Increasing (LI; 19.2%), Moderate-Decreasing (MD; 32.9%), and High-Stable (HS; 7.2%). Child FSIQ and caregiver age at baseline were lower and caregiver depression at baseline was higher for participants in the MD group than the LS group. Psychotropic medication use was associated with higher attention problems. The MD and HS groups had similar mean Vineland Adaptive Behavior Scales, Second Edition (VABS-II) Socialization standard scores at T8, which were lower than other groups. The LI group had lower Socialization scores than the LS group. Results support that a decline in caregiver-reported attention problems is common but not universal in autistic children and that even moderate/subclinical attention problems may relate to social skills outcomes in autism.

Young people with childhood adversity (CA) were at increased risk to experience mental health problems during the COVID-19 pandemic. Pre-pandemic research identified high-quality friendship support as a protective factor that can buffer against the emergence of mental health problems in young people with CA. This longitudinal study investigated friendship buffering effects on mental health symptoms before and at three timepoints during the pandemic in 102 young people (aged 16–26) with low to moderate CA. Multilevel analyses revealed a continuous increase in depression symptoms following the outbreak. Friendship quality was perceived as elevated during lockdowns and returned to pre-pandemic baseline levels during reopening. A stress-sensitizing effect of CA on social functioning was evident, as social thinning occurred following the outbreak. Bivariate latent change score modeling revealed that before and during the pandemic, young people with greater friendship quality self-reported lower depression symptoms and vice versa. Furthermore, sequential mediation analysis showed that high-quality friendships before the pandemic buffered depression symptoms during the pandemic through reducing perceived stress. These findings highlight the importance of fostering stable and supportive friendships in young people with CA and suggest that through reducing stress perceptions high-quality friendships can mitigate mental health problems during times of multidimensional stress.

Psychopathology assessed across the lifespan often can be summarized with a few broad dimensions: internalizing, externalizing, and psychosis/thought disorder. Extensive overlap between internalizing and externalizing symptoms has garnered interest in bifactor models comprised of a general co-occurring factor and specific internalizing and externalizing factors. We focus on internalizing and externalizing symptoms and compare a bifactor model to a correlated two-factor model of psychopathology at three timepoints in a large adolescent community sample (N = 387; 55 % female; 83% Caucasian; M age = 12.1 at wave 1) using self- and parent-reports. Each model was tested within each time-point with 25–28 validators. The bifactor models demonstrated better fit to the data. Child report had stronger invariance across time. Parent report had stronger reliability over time. Cross-informant correlations between the factors at each wave indicated that the bifactor model had slightly poorer convergent validity but stronger discriminant validity than the two-factor model. With notable exceptions, this pattern of results replicated across informants and waves. The overlap between internalizing and externalizing pathology is systematically and, sometimes, non-linearly related to risk factors and maladaptive outcomes. Strengths and weaknesses to modeling psychopathology as two or three factors and clinical and developmental design implications are discussed.

Polygenic scores (PGSs) have garnered increasing attention in the clinical sciences due to their robust prediction signals for psychopathology, including externalizing (EXT) behaviors. However, studies leveraging PGSs have rarely accounted for the phenotypic and developmental heterogeneity in EXT outcomes. We used the National Longitudinal Study of Adolescent to Adult Health (analytic N = 4,416), spanning ages 13 to 41, to examine associations between EXT PGSs and trajectories of antisocial behaviors (ASB) and substance use behaviors (SUB) identified via growth mixture modeling. Four trajectories of ASB were identified: High Decline (3.6% of the sample), Moderate (18.9%), Adolescence-Peaked (10.6%), and Low (67%), while three were identified for SUB: High Use (35.2%), Typical Use (41.7%), and Low Use (23%). EXT PGSs were consistently associated with persistent trajectories of ASB and SUB (High Decline and High Use, respectively), relative to comparison groups. EXT PGSs were also associated with the Low Use trajectory of SUB, relative to the comparison group. Results suggest PGSs may be sensitive to developmental typologies of EXT, where PGSs are more strongly predictive of chronicity in addition to (or possibly rather than) absolute severity.

Child socioemotional difficulties emerge as early as infancy, increase over time, and place children at risk for future internalizing and externalizing symptoms. The aim of the present study was to investigate pathways that originate within the interparental relationship during pregnancy and unfold during infancy that mitigate risk for toddler socioemotional difficulties and to examine the differential effects of these pathways for children with varying degrees of temperamental fearfulness. Specifically, we examined whether dyadic mutually responsive orientation (MRO; i.e., a system of attunement, reciprocity, cooperation, and warmth) observed in the prenatal interparental relationship and in both mother-infant and father-infant relationships predicted child socioemotional functioning at age 2. Findings revealed a significant direct effect of observed prenatal interparental MRO on mother-infant and father-infant MRO. Results also demonstrated an indirect effect of prenatal interparental MRO on socioemotional functioning via father-infant MRO. Temperamental fearfulness did not interact with interparental MRO, mother-infant MRO, or father-infant MRO to impact socioemotional functioning. Taken together, findings suggest high interparental MRO during pregnancy contributes to similar relational qualities in the parent-infant relationship and mitigates the risk for toddler socioemotional difficulties. Further, results underscore the importance of integrating fathers into prevention and intervention efforts when they are part of the family system.

Social anxiety and depression exacerbate in early adolescence. Maladaptive self-referential processing confers risk for both conditions and can be assessed by the Self-Referent Encoding Task (SRET). Our cross-sectional findings indicated that the SRET-elicited anterior late positive potential (LPP) was uniquely associated with social anxiety symptoms, whereas behavioral SRET scores were uniquely associated with depressive symptoms. Expanding this work, this study investigated whether the SRET-generated behavioral and LPP indices differentially predicted changes of social anxiety or depressive symptoms over time. At baseline, 115 community-dwelling youths (66 girls; Mean age/SD = 11.00/1.16 years) completed an SRET with EEG. Youths reported social anxiety and depressive symptoms at baseline and ∼six and ∼ 12 months later, based on which the intercept and slope of symptoms were estimated as a function of time. A larger anterior LPP in the negative SRET condition uniquely predicted a larger slope (faster increase) of social anxiety (but not depressive) symptoms. Greater positive behavioral SRET scores marginally predicted a smaller slope (slower increase) of depressive (but not social anxiety) symptoms. We provided novel evidence concerning the differential, prospective associations between self-referential processing and changes of social anxiety and depressive symptoms in early adolescence.

Coordination in mothers’ and their infants’ parasympathetic nervous system functioning (i.e., respiratory sinus arrhythmia [RSA] synchrony) specifically during playful interactions may promote resilience against exposure to postpartum depressive symptoms (PPD), for both members of the dyad. To test biobehavioral synchrony theory-derived hypotheses, we evaluated whether positive mother-infant RSA synchrony during play attenuated associations between maternal PPD symptoms and future child behavior problems and maternal depressive symptoms. 322 low-income, Mexican-origin mothers and their children participated in 5-min resting baseline and free play interaction tasks when children were 24 weeks of age; mothers reported on their PPD symptoms and on child behavior problems and maternal depressive symptoms at 12- and 36-months child age. Results of multilevel structural equation models demonstrated that, though the associations between maternal PPD symptoms and future child behavior problems and maternal depressive symptoms differed depending on levels of RSA synchrony during play and non-interactive tasks, the protective benefits of positive RSA synchrony on 12-month maternal depressive symptoms and 36-month child internalizing problems were specific to its assessment during a playful interaction. Results suggest that the dyadic coordination of physiological capacities during playful interactions is an active mechanism that promotes resilience to emotional distress for mothers and their children.

The development of inhibitory control (IC) and working memory (WM) in preschool is linked to a multitude of cognitive, emotional, and social outcomes, including elementary school adjustment. Furthermore, there are both cognitive and socioemotional domains of IC and it is unclear if both are related to these outcomes in the same manner. Using a family study design, the present investigation examined preschoolers’ IC, WM and externalizing behavior problems, maternal depression and anxiety measured when the children were in preschool, and elementary school externalizing behaviors and child and family functioning. Families with two children between 2.5 and 5.5 years of age (n = 198; mean age = 3.88, SD = 1.04) completed online surveys and laboratory visits, as well as another online survey after the children entered elementary school. Both cognitive and emotional domains of preschool IC significantly predicted the externalizing and functioning aspects of adjustment in elementary school (but WM did not predict either). In addition, child age predicted functioning in elementary school, and maternal depression predicted externalizing in elementary school. These longitudinal results indicate that supporting both cognitive and emotional aspects of preschool IC can benefit adjustment in elementary school.

This study investigates whether lower self-regulation (SR) facets are risk factors for internalizing symptoms (vulnerability models), consequences of these symptoms (scar models), or develop along the same continuum and thus share common causes (spectrum models) during middle childhood. To analyze these models simultaneously, a random intercept cross-lagged panel model was estimated using Mplus. Data were assessed at three measurement time points in a community-based sample of N = 1657 (52.2% female) children in Germany, aged 6–13. Internalizing symptoms were measured via parent report by the emotional problems scale of the Strengths and Difficulties Questionnaire. Seven SR facets were assessed behaviorally, via parent report and teacher report. At the within-person level, internalizing symptoms were concurrently associated with emotional reactivity at all measurement time points, while no cross-lagged paths reached significance. At the between-person level, internalizing symptoms were associated with working memory updating (r = −.29, p < .001), inhibitory control (r = −.29, p < .001), planning behavior (r = −.49, p < .001), and emotional reactivity (r = .59, p < .001). As internalizing symptoms and SR facets were primarily associated at the between-person level, the results lend support to spectrum models suggesting common causes of internalizing symptoms and impaired SR.

There is a lack of longitudinal data on the relationship between upward social comparison on social network sites (SNSs) and depression and its underlying mechanisms. Therefore, this study aimed to examine the relationship between upward social comparison on social network sites and depression and analyze the mediating effects of self-concept clarity and self-esteem in this relationship. We employed a two-wave longitudinal design among 1179 Chinese middle school students. The results indicated that : upward social comparison on SNSs predicted middle school students’ depression; Self-concept clarity and self-esteem sequentially mediated the relationship between upward social comparison on SNSs and middle school students’ subsequent depression. These results suggested that three types of interventions could be effectively used to decrease the risk of depression among middle school students.

The ability to detect and monitor errors enables us to maintain optimal performance across tasks. One neurophysiological index of error monitoring is the error-related negativity (ERN), a fronto-central negative deflection peaking between 0 and 150 ms following an erroneous response. While the developmental literature has illustrated age-related differences in the ERN and its association with anxiety, the literature has mainly focused on the between-person differences of the ERN. Our study examined the within-person variations of the ERN in 115 community-dwelling 9- to 12-year-olds (66 girls; mean age/SD = 11.00/1.16 years). Participants completed an EEG Go/No-Go task and reported their anxiety symptoms. Multilevel growth analyses yielded significant within-person, curvilinear changes in the ERN throughout the task. Youths’ trial-level ERN increased (i.e., became more negative) with early errors, but decreased with subsequent errors. This curvilinear pattern was evident in older, but not younger, youths. Age also interacted with anxiety symptoms: younger youths with higher anxiety showed a continuous increase in the ERN throughout the task, whereas older youths with higher anxiety showed an initial increase followed by a decline in the ERN. Our study contributed novel evidence for the development of the ERN and the underlying mechanisms of the ERN-anxiety relationship that cannot be captured by between-person approaches.

This study investigated the psychometric properties of the Highly Sensitive Child-Rating System (HSC-RS), the existence of sensitivity groups, and the characterization of sensitivity at behavioral, genetic, and physiological levels in 541 preschoolers (M(SD)age = 3.56(0.27); 45%male; 87%Caucasian). Temperament, genetic, cortisol, and electroencephalography asymmetry data were collected in subsamples (n = 94-476). Results showed a reliable observational measure of sensitivity. Confirmatory factor and latent class analysis supported a one-factor solution and three sensitivity groups, that are a low (23.3%), medium (54.2%), and a high (22.5%) sensitivity group. Hierarchical regression analyses showed moderate associations between HSC-RS and observed temperament traits (i.e., behavioral level). In addition, a small negative association between HSC-RS and a genome-wide association study polygenic risk score (GWAS PGS) for Attention Deficit Hyperactivity Disorder was found. No relations with candidate genes, other GWAS PGS phenotypes, and physiological measures were found. Implications of our findings and possible explanations for a lack of these associations are discussed.

Adolescence and young adulthood are sensitive developmental periods to environmental influences. Investigating pre-emptive measures against stressors, such as those associated with the COVID-19 pandemic, on mental health is crucial. We aimed to synthesize evidence on pre-pandemic resilience factors shaping youth mental health outcomes during this period. For this pre-registered systematic review, we searched seven databases for longitudinal studies of youth populations affected by the COVID-19 pandemic, assessing a priori defined resilience factors at the individual, family, or community level before the pandemic. Studies required validated mental health or wellbeing measures collected both before and during the pandemic. Study quality was assessed using the corresponding NIH Quality Assessment Tool. From 4,419 unique records, 32 studies across 12 countries were included, using 46 distinct resilience measures. Due to the heterogeneity of study designs, we applied a narrative synthesis approach, finding that resilience factors were generally associated with better mental health outcomes both prior to and during the pandemic. However, most factors did not mitigate pandemic-related mental health effects. Nonetheless, family-level resilience factors emerged as promising under specific conditions. Study quality was generally fair, with concerns in resilience assessment and sampling quality. Future research should prioritize rigorous study designs and comprehensive resilience assessments.

Suicide is one of the leading causes of death among individuals aged 10–24. Research using intensive longitudinal methods to identify near-term predictors of suicidal thoughts and behaviors (STBs) has grown dramatically. Interpersonal factors may be particularly critical for suicide risk among young people, given the heightened salience of interpersonal experiences during adolescence and young adulthood. We conducted a narrative review on intensive longitudinal studies investigating how interpersonal factors contribute to STBs among adolescents and young adults. Thirty-two studies met the inclusion criteria and focused on theoretical and cross-theoretical interpersonal risk factors. Negative interpersonal states (e.g., perceived burdensomeness), hopelessness, and social support were consistently associated with proximal within-person changes in concurrent, but not prospective, suicidal thoughts. Further, work examining how these processes extend to suicidal behavior and among diverse samples remains scarce. Implications for contemporary interpersonal theories and intensive longitudinal studies of STBs among young people are discussed.