Report of the result of familial examinations on 49 stillborn of before half year of life died and dissected children with lethal anomalies.
1. In two of 4 families, whose probands suffered from harelip and clett palate combined with other deformities, is supposed, that—just like harelip and clett palate without other malformations—an unstable dominant gen being origin of the mistake of development.
In one case with a special severe combination and probable consanguinity of the parents is to think of homozygoty.
In a fourth case the question of the origin of the combined deformities by « psychical trauma » may be discussed.
2. In 32 families the cause of death of the probands is to be seen in a lethal closing mistake of the vetebral column.
a) In seven of 20 families with an anencephalus signs of « Dysraphies » and other anomalies were found which may be caused by pathological gens. One time both parents of a (homozygote?) anencephalus who showed deformities of heart and limbs had Spina bifida occulta.
b) In 5 of 12 families with Spina bifida aperta was the cause of deformation an unstable unregular dominant gen. In two other families is this probable.
Anencephalie and Spina bifida aperta may be found together in the same family. Heterogenie ist probable for both.
3. a) Hydrocephalie without other deformities was in 8 families not inherited.
b) 4 families with microcephaly showed differences. Dominant gens for « Dysraphies » and recessive gens may bring about microcephaly.
c) Consanguinity of the parents in a case of cyklopy is seen to be sign of recessive inheritance.