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Publisher:
Cambridge University Press
Online publication date:
August 2009
Print publication year:
2007
Online ISBN:
9780511541766

Book description

MicroRNAs (miRNAs) are RNA molecules, conserved by evolution, that regulate gene expressions and their discovery has revolutionised both basic biomedical research and drug discovery. Expression levels of miRNAs have been found to vary between tissues and with developmental stages and hence evaluation of the global expression of miRNAs potentially provides opportunities to identify regulatory points for many different biological processes. This wide-ranging reference work, written by leading experts from both academia and industry, will be an invaluable resource for all those wishing to use miRNA techniques in their own research, from graduate students, post-docs and researchers in academia to those working in R&D in biotechnology and pharmaceutical companies who need to understand this emerging technology. From the discovery of miRNAs and their functions to their detection and role in disease biology, this volume uniquely integrates the basic science with industry application towards drug validation, diagnostic and therapeutic development.

Reviews

'… comprehensive and detailed … compiled logically … informative and easy to read.'

Source: Microbiology Today

'… a useful reference guide for those interested in miRNA …'

Source: Immunology News

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Contents


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  • 23 - High throughput microRNAs profiling in cancers
    pp 309-321
    • By Muller Fabbri, Center for Human Cancer Genetics The Ohio State University Comprehensive Cancer Center 385L Comprehensive Cancer Center 410 West 10th Avenue Columbus, OH 43210 USA, Ramiro Garzon, Center for Human Cancer Genetics The Ohio State University Comprehensive Cancer Center 385L Comprehensive Cancer Center 410 West 10th Avenue Columbus, OH 43210 USA, Amelia Cimmino, Center for Human Cancer Genetics The Ohio State University Comprehensive Cancer Center 385L Comprehensive Cancer Center 410 West 10th Avenue Columbus, OH 43210 USA, George Adrian Calin, Center for Human Cancer Genetics The Ohio State University Comprehensive Cancer Center 385L Comprehensive Cancer Center 410 West 10th Avenue Columbus, OH 43210 USA, Carlo Maria Croce, Center for Human Cancer Genetics The Ohio State University Comprehensive Cancer Center 385L Comprehensive Cancer Center 410 West 10th Avenue Columbus, OH 43210 USA

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