The earliest recorded observations of Antarctic icebergs occurred in 1688 and 1700 in the Gregorian New Style (NS) Calendar. The first sighting took place after Christmas 1687 in the Julian Old Style (OS) Calendar, when just north of the Antarctic Peninsula, Edward Davis observed “ice islands” with lengths of 5–10 km; the second occurred in February 1699 OS, when north of South Georgia, Edmond Halley observed and first sketched tabular icebergs. Although these were the earliest documented observations, because icebergs occur adjacent to New Zealand and South America, seagoing Māori and indigenous South Americans may have observed them eight centuries earlier. Davis and Halley’s observations were in the iceberg stream that flows to the east of the Antarctic Peninsula. Davis’s observations were the result of the Batchelor’s Delight being blown south from Cape Horn by a storm; his misadjusted compass meant they sailed east across instead of north through the stream. Comparison of Davis’s positions with satellite iceberg trajectories suggests his observations occurred at 62.5°S between 53.0° and 54.3°W. Davis assumed his icebergs were floating, but because Halley’s ice islands appeared stationary, he thought they were grounded, missing an opportunity to speculate on the existence of a southern ice-covered continent.

Parental surrogacy remains a highly controversial issue in contemporary ethics with considerable variation in the legal approaches of different jurisdictions. Finding a societal consensus on the issue remains highly elusive. John Rawls’ theory of public reason, first developed in his A Theory of Justice (1971), offers a unifying model of political discourse and engagement that enables reasonable citizens to accept policies that they do not necessarily support at a personal level. The theory established a promising framework for private citizens with distinct moral positions on the subject to find common ground and, in doing so, to negotiate a consensus regarding the degree and nature of regulation that is palatable to all rational citizens.

We present the case of a 31-year-old female with Fontan circulation who developed signs of protein-losing enteropathy 10 days after second COVID-19 vaccination. After standard investigations for identification of potential triggers for protein-losing enteropathy, we concluded that coronavirus disease 2019 (COVID-19) booster vaccination could have been the most probable underlying trigger. Prompt investigation of new symptoms post-vaccination in high-risk patients is necessary.

Plant secondary metabolites (PSMs) may improve gastrointestinal health by exerting immunomodulatory, anti-inflammatory and/or antiparasitic effects. Bark extracts from coniferous tree species have previously been shown to reduce the burden of a range of parasite species in the gastrointestinal tract, with condensed tannins as the potential active compounds. In the present study, the impact of an acetone extract of pine bark (Pinus sylvestris) on the resistance, performance and tolerance of genetically diverse mice (Mus musculus) was assessed. Mice able to clear an infection quickly (fast responders, BALB/c) or slowly (slow responders, C57BL/6) were infected orally with 200 infective third-stage larvae (L3) of the parasitic nematode Heligmosomoides bakeri or remained uninfected (dosed with water only). Each infection group of mice was gavaged for 3 consecutive days from day 19 post-infection with either bark extract or dimethyl sulphoxide (5%) as vehicle control. Oral administration of pine bark extract did not have an impact on any of the measured parasitological parameter. It did, however, have a positive impact on the performance of infected, slow-responder mice, through an increase in body weight (BW) and carcase weight and reduced feed intake by BW ratio. Importantly, bark extract administration had a negative impact on the fast responders, by reducing their ability to mediate the impact of parasitism through reducing their performance and tolerance. The results indicate that the impact of PSMs on parasitized hosts is affected by host's genetic susceptibility, with susceptible hosts benefiting more from bark extract administration compared to resistant ones.

Daniel Immerman has recently put forward a novel account of harm, the Worse than Nothing Account. We argue that this account faces fatal problems in cases in which an agent performs several simultaneous actions. We also argue that our criticism is considerably more powerful than another one that has recently been advanced.

The capacocha was one of the most important types of Inca sacrifices. Road stations (tambos) were built for the pilgrims who travelled to mountain peaks with the sacrifices. Spatial analysis of two tambos on the slopes of the Pichu Pichu and Chachani volcanoes in Peru reveals segregation in the sacred landscape.

We report on four brachyuran crabs collected from the carapaces of loggerhead sea turtles Caretta caretta nesting on Yakushima Island in Kagoshima prefecture, Japan. Three of these crab species have not been previously reported as epibionts on sea turtles. Our research suggests that physical damage to a turtle's carapace, such as cracks and holes created by other epibionts like the burrowing barnacle Tubicinella cheloniae, can create unique habitats for these opportunistic crabs.

This article traces how the Yemeni-origin Sufi order of Ṭarīqa ʿAlawiyya and its ritual litany of al-Ḥaddād, with chants and prayers for the Prophet and his descendants especially from Hadramawt, became part of everyday Muslim devotional practices in Malabar through immigrant networks of Hadrami Sayyids. Competing, sometimes rivalling, and appropriating other Sufi religiosities, the Alawi order meaningfully involved within the theo-legal Sufi discourses that have been remoulding the Sufi cosmopolis in the Indian Ocean. By focusing on two notable early immigrant Sayyids in Malabar, this article argues that the successful placement of the ʿAlawī order within the Sufi cosmopolis and the permeation of the ritual was a complex socio-religious project that was brought forth by various aspects of the sacred genealogy, Alawi Sufi writings, Sufi activism, and the effective utilisation of Hadrami immigrant networks.

This study explores several alternative specifications of futures-based forecasting models to improve existing approaches constrained by restrictive assumptions and limited information sets. In lieu of historical averages, our approaches use rolling regressions and include current market information reflected in the deviation of the current basis from its historical average. To mitigate potential challenges arising from nonstationarity and structural changes in the relationship between farm and futures prices, we employ a 5-year rolling estimation window. We find that a rolling regression approach offers significant improvements (as evidenced by our Modified Diebold–Mariano test) in the accuracy and information content of forecasts of cotton season-average prices (SAPs) mostly at short forecast horizons.

Who deserves credit for epistemic successes, and who is to blame for epistemic failures? Extreme views, which would place responsibility either solely on the individual or solely on the individual’s surrounding environment, are not plausible. Recently, progress has been made toward articulating virtue epistemology as a suitable middle ground. A socio-environmentally oriented virtue epistemology can recognize that an individual’s traits play an important role in shaping what that individual believes, while also recognizing that some of the most efficacious individual traits have to do with how individuals structure their epistemic environments and how they respond to information received within these environments. I contribute to the development of such an epistemology by introducing and elucidating the virtue of epistemic exactingness, which is characterized by a motivation to regulate the epistemically significant conduct of others.

This article presents the preliminary results of investigations at the site of Qach Rresh on the Erbil Plain of the Kurdistan Region of Iraq, conducted by the Rural Landscapes of Iron Age Imperial Mesopotamia project (RLIIM). The site of Qach Rresh is estimated to have been founded in the mid–eighth century B.C.E., at the height of the Assyrian Empire, and continued to be utilised in varying capacity until the onset of the Hellenistic period (c. 320 B.C.E.). Magnetic gradiometry survey and excavations currently suggest that Qach Rresh served as a rural administrative/storage center during the Assyrian Empire, which fell into disrepair following the empire’s collapse. The following post-Assyrian/Iron Age III period then saw several of its large buildings repurposed as refuse areas containing debris from largely domestic contexts. Qach Rresh is the first rural settlement investigated within the Assyrian imperial heartland. The results from this project seem to indicate a high degree of Assyrian state or elite involvement in the countryside, serving as a critical first foray into assessing the relationship between urban governing centers and their “hinterlands”.

What follows is a sketch of three of the main claims of How to Pool Risks across Generations: The Case for Collective Pensions (Otsuka 2023) with which my symposium commentators critically engage: namely, that (1) by efficiently pooling risks across as well as within generations, (2) collective pensions can realize a form of Rawlsian reciprocity involving fair terms of cooperation for mutual advantage, (3) through the voluntary binding agreements of individuals to join a mutual association that provides social insurance. I respond to their challenges to these claims in my replies that follow their contributions.

Interviews with 22 home-based primary care (HBPC) clinicians revealed that infectious disease physicians and clinical pharmacists facilitate infection management and antibiotic selection, respectively, and that local initiatives within programs support antibiotic prescribing decisions. Interventions that facilitate specialist engagement and tailored approaches that address the unique challenges of HBPC are needed.

Early warning for epilepsy patients is crucial for their safety and well being, in particular, to prevent or minimize the severity of seizures. Through the patients’ electroencephalography (EEG) data, we propose a meta learning framework to improve the prediction of early ictal signals. The proposed bilevel optimization framework can help automatically label noisy data at the early ictal stage, as well as optimize the training accuracy of the backbone model. To validate our approach, we conduct a series of experiments to predict seizure onset in various long-term windows, with long short-term memory (LSTM) and ResNet implemented as the baseline models. Our study demonstrates that not only is the ictal prediction accuracy obtained by meta learning significantly improved, but also the resulting model captures some intrinsic patterns of the noisy data that a single backbone model could not learn. As a result, the predicted probability generated by the meta network serves as a highly effective early warning indicator.