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This chapter concludes that the individual is considered in the legal reasoning of the Court in the identified contexts to a minor extent and offers reflections on the reasons for this. It recapitulates reflections on formalism and stability that are key in maritime and territorial boundary disputes. It notes that the Court is correctly limited to the request of the parties and cannot innovate beyond their submissions. However, across all chapters it was observed that state litigants often raise concerns about individuals in their custody. It therefore challenges the Court’s judicial caution when faced with potentially developing international law in addressing state’s concerns. It argues that while the Court does not have a formal law-making function, it develops international law nonetheless through its interpretations and clarifications and should not hesitate to do so when clarification is sought by state litigants on matters relating to the affected individuals in such disputes.
Kawasaki disease is a leading cause of acquired heart disease in children in the developed world, characterised by acute systemic vasculitis, with a complex aetiology that remains poorly understood. Recent studies have highlighted the potential anti-inflammatory effects of Interleukin-35 in various proinflammatory and cardiovascular conditions. However, the relationship between Interleukin-35 gene polymorphisms and Kawasaki disease susceptibility, particularly in Chinese children, has not been well-explored.
In this study, we investigated the association between five Interleukin-35 single-nucleotide polymorphisms—rs2243115, rs2243123, rs583911, rs353698, and rs2302164—and Kawasaki disease in a cohort of Chinese children. A total of ninety-four Kawasaki disease patients and one hundred healthy controls were enrolled, with the Kawasaki disease patients further divided into subgroups based on the presence or absence of coronary artery lesions and incomplete or complete Kawasaki disease. Genotyping of Interleukin-35 polymorphisms was performed using the MassARRAY system.
The results showed the GT + GG genotypes and G allele of rs2243115 (T > G) were significantly more prevalent in Kawasaki disease patients with coronary artery lesions than in those without coronary artery lesions, suggesting a possible association with the development of coronary artery lesions. Additionally, the G allele of rs353698 (A > G) was more frequently observed in the incomplete Kawasaki disease group compared to the complete Kawasaki disease group, suggesting a possible association with the risk of incomplete Kawasaki disease.
We consider parallel plane (pp) waves, solutions of Einstein’s equations for which the linearized equation is exact. We describe the Penrose theorem, for the Penrose limit, saying that in the neighborhood of a null geodesic, any space looks like a pp wave. We exemplify it for AdS3 × S3. We then consider gravitational shockwaves, an example of pp waves, in flat space, and in other backgrounds. Finally, we describe the Khan–Penrose interacting solution, for the head-on collision of two gravitational shockwaves.
Travelling wave charges lying on the insulating walls of an electrolyte-filled capillary give rise to oscillatory modes which vanish when averaged over the period of oscillation. They also give rise to a zero mode (a unidirectional, time-independent velocity component) which does not vanish. The latter is a nonlinear effect caused by continuous symmetry breaking due to the quadratic nonlinearity associated with the electric body force in the time-dependent Stokes equations. In this paper, we provide a unified view of the effects arising in boundary-driven electrokinetic flows (travelling wave electroosmosis) and establish the universal behaviour exhibited by the observables. We show that the incipient velocity profiles are self-similar implying that those obtained with a single experimental configuration can be employed again to attain further insights without the need of repeating the experiment. Certain results from the literature are recovered as special cases of our formulation and we resolve certain paradoxes having appeared in the past. We present simple theoretical expressions, depending on a single-fit parameter, that reproduce these profiles, which could thus provide a rapid test of consistency between our theory and future experiment. The effect becomes more pronounced when reducing the transverse dimension of the system, relative to the velocity direction, and increasing the excitation wavelength, and can therefore be employed for unidirectional transport of electrolytes in thin and long capillaries. General relations, expressing the zero mode velocity in terms of the electric potential and the geometry of the system only, can thus be easily adapted to alternative experimental settings.
Chapter III focuses on another key feature of Tolkien’s literary technique, namely the lavish use of omissions, allusive language, and, more specifically, the deletion of (almost) all the explicit references to the hidden ‘divine narrative’ underlying the story; these are scattered throughout the book, but always in a ‘hidden’ or ‘glimpsed’ form. The second part explores the theoretical implications of this poetics of ‘cloaking’ or ‘glimpsing’. This technique evokes in the reader a “heart-racking” longing for something unattainable. This is not just a (well-paralleled) strategy: rather, literature for Tolkien does not just come from the human mind, since human beings are only sub-creators, and the light that their works refract comes from a higher Light: incompleteness and cloaking are thus means by which Tolkien acknowledges the mysterious origin of his sub-creations, and at the same time expresses God’s high concern for freedom, His own and that of the human sub-creators and their readers.
The sixteenth and early seventeenth centuries marked a deep crisis of the international political and legal order of Europe, caused by the Reformation, the emergence of some strong composite monarchies and the discovery of the New World. The chapter maps how the law of nations began to emerge as a new paradigm for the governance of Europe under whose wings rulers, diplomats and scholars attempted to advance claims to an exclusive jurisdiction over international relations by sovereign princes and republics. As such, the ‘law of nations’ functioned as a lever, an argument for power in a period of great clashes between centralising governments, opposing confessions, and regional and local elites, rather than representing a reality. The ultimate success by governments in several important states at the end of the Renaissance was facilitated to a great extent by the patrimonial and transactional nature of the states that allowed to include old, autonomous powers in the machinery of state.
The duration of undiagnosed or untreated bipolar disorder (DUBD) has become a focus of research interest. However, its relationship with clinical characteristics and outcomes remains poorly understood.
Aims
The objective of this systematic review and meta-analysis was to examine DUBD and explore its relationships with clinical characteristics and outcomes in bipolar disorder.
Methods
We conducted a systematic search of the literature to identify studies reporting on DUBD and its relationships with clinical characteristics and outcomes including frequency of relapse into mood episodes, severity and persistence of mood symptoms, functional and cognitive measures, suicidality, hospital admission rate, and comorbidities such as substance use disorders.
Results
Thirty articles met inclusion criteria for the systematic review, and 23 studies were included in the three different sets of meta-analyses. The pooled mean DUBD across all studies was 9.10 years. Early onset, depression as the polarity of the first mood episode, lifetime suicide attempts, comorbid anxiety and alcohol use disorders, and family history of bipolar disorder were associated with significantly longer DUBD, whereas diagnosis of bipolar I disorder and lifetime psychotic symptoms were associated with shorter DUBD. Studies that investigated outcomes subsequent to the diagnosis of bipolar disorder yielded conflicting results.
Conclusion
DUBD may be associated with certain adverse outcomes. This association indicates the importance of adopting a more comprehensive approach to assessing mood disorders, with an emphasis on prioritising early screening for bipolar disorder. The significant heterogeneity among included studies suggests a need for improved methodological rigour in future research.
Chapter IV discusses another important feature of Tolkien’s work, that is, the vast amount of narrative parallelism, both intra- and intertextual, focusing on some case studies (including the relation between the hero Beren and the hobbit Frodo in particular). These parallels are related to Tolkien’s belief in “the seamless web of story”, that is to say, to the view that there is only one single Tree of Tales, criss-crossing primary and secondary realities, which sprouts again and again with new branches and leaves, all different and yet all similar. This ‘organic’ image is helpful to understand key aspects of Tolkien’s literary ‘theory’, including his famous aversion to allegory, which is here related to his belief that literature embodies in new “modes” the same universal “motives” but in a way that is ‘unexpected’ and ‘unconscious’, and the conviction that all stories correlate with each other in a narrative chain having its centre in the Gospel Story.
The present chapter addresses the creation process of the fundamental dichotomic system of the modern law of the sea, viz. territorial sea and high seas, in Old Regime Europe thorough the analyses of ‘state practices’ and doctrines regarding dominium maris, based on some preceding historical backgrounds. It also discusses two neglected issues in order to grasp the accurate, at least theoretically, traces in establishing the current perception of ‘territorial sea’ emanating from the ‘cannon-shot rule’, most famously propounded by Bynkershoek for defining the outer limit of the adjacent sea. The discussion concludes that, although the basic notion of the modern dichotomic system had generally been recognised during the epoch surveyed, no unified criterion for determining the extent of the terrestrial authority over the sea had emerged. It suggests, in the end, the importance of two Italians, Galiani and Azuni, as the earliest known theorists who proposed the theoretical equation of the rules of cannon-shot and three-mile limit and indicates the necessity of fathoming the complex spoors of the history of the law of the sea originating from immensely diverse theories and practices.