Grey seals from both the Atlantic and Baltic Sea subspecies are recovering from dramatic declines and recolonising former ranges, potentially leading to overlapping distributions and an emerging subspecies transition zone in Kattegat between Denmark and Sweden. The two subspecies have asynchronous moulting and pupping seasons. We present aerial survey data from 2011 to 2023 in Danish Kattegat during the Atlantic subspecies' moulting (March–April) and pupping (December–January) seasons, as well as the Baltic subspecies' moulting season (May–June). During the Atlantic subspecies' peak moulting season, 82% of the grey seals were recorded north of the island of Læsø (N57°18′, E11°00′). In contrast, during the Baltic moulting season in those years, only 9% of the grey seals were recorded here. This indicates a predominance of Atlantic grey seals in the north and Baltic grey seals in central and southern Kattegat. In 2022 and 2023, three pups were recorded around Læsø during early January, which coincides with the pupping season of northern Wadden Sea grey seals. Previously, pups have been recorded in the same locations during the Baltic pupping season, which demonstrates overlapping breeding ranges. Grey seals are known to have plasticity in the timing of pupping indicated by a west to east cline of progressively later pupping in the eastern North Atlantic. Historical sources document that the Baltic pupping season in Kattegat was earlier than it has been in recent years. Thus, the expanding ranges may be associated with convergence of Atlantic and Baltic subspecies' pupping seasons and potential hybridisation in this emerging transition zone.

The hybridisation of welfare regimes is a critical issue in social policy literature due to the lack of a uniform dependent variable and the comparative, international scope of social policy analysis, and data availability. We argue that what is presented in the global welfare regime literature as an analytical problem of classification or transitioning could also, in fact, be treated as a methodological issue. Based on this, we aim to establish a criterion for determining the membership of a welfare regime by capturing the presence of hybridisation of welfare regimes in a given country at a particular time. We present a novel methodological approach based on multistage sampling to capture the hybridisation of distinct welfare regimes and determine the most populous cluster in Pakistan. Establishing criteria for capturing and determining welfare regime membership can improve the understanding of welfare regime dynamics and factors that contribute to hybridisation. Ultimately, this knowledge can inform policy decisions and contribute to the development of more effective welfare systems for diverse populations.

In a sculpted frieze on a lintel of the so-called Temple of Allat at Hatra (second century AD), two rows of sitting camels converge towards a possible royal portrait. The two lead animals were previously interpreted as Bactrian camels. We reconsider this interpretation in light of recent information on ancient and contemporary practices of hybridisation between Camelus bactrianus and Camelus dromedarius.

Exceptional aspects of the design and location of a pair of first-century fortlets on the Exmoor coast are explicable as a product of local influence. Previous explanations for the remote setting of these small posts and the distinctive defences securing them have focused on a signalling role, with the fortlets serving as a means to transmit messages to naval vessels patrolling the Bristol Channel. Instead, both the landscape setting and articulation with local settlement patterns imply that these installations strengthened pre-existing measures to counter coastal raiding. Parallels between this variant fortlet design and settlement morphology in the South-West peninsula suggest that the army co-opted an indigenous architectural style. The two fortlets could act as components of what was effectively a composite coastal cordon, built on collaboration between the Roman military and the local population.

The present article seeks to fill a number of lacunae with regard to the study of the circulation and assimilation of different bodies of medical knowledge in an important cultural contact zone, that is the Upper Guinea Coast. Building upon ongoing research on trade and cultural brokerage in the area, it focuses upon shifting attitudes and practices with regard to health and healing as a result of cultural interaction and hybridisation against the background of growing intra-African and Afro-Atlantic interaction from the fifteenth to the late seventeenth century. Largely based upon travel accounts, missionary reports and documents produced by the Portuguese Inquisition, it shows how forms of medical knowledge shifted and circulated between littoral areas and their hinterland, as well as between the coast, the Atlantic and beyond. It shows that the changing patterns of trade, migration and settlement associated with Mandé influence and Afro-Atlantic exchange had a decisive impact on changing notions of illness and therapeutic trajectories. Over the centuries, cross-cultural, reciprocal borrowing contributed to the development of healing kits employed by Africans and non-African outsiders alike, which were used and brokered by local communities in different locations in the region.

Ducks (common, Muscovy and mule ducks) are the third most important bird species in animal production for human consumption worldwide. Our study aimed to improve the efficiency of mule duck breeding, thus contributing to the efficiency of food production in general. In the common duck, females can be bred either with males of the same species (i.e. in pure breeding (PB) subscript p) or in inter-generic crossbreeding (CB; subscript c) with Muscovy drakes to produce the hybrid mule duck. The aim of the present study was to estimate the genetic parameters of several indicators of duration of fertility, considered to be a trait of the female duck, within and between breeding schemes and, in particular, to estimate the purebred–crossbred genetic correlation (rgpc). These indicators were maximum duration of fertility (MD), that is, the time interval between insemination and the last fertilised egg, the number of fertile eggs (F) and of hatched ducklings (H) after a single artificial insemination (AI), and the fertility rate over days 2 to 12 after AI (F2,12), taking three sub-periods (F2,4, F5,8, F9,12) into account. A total of 494 females and 2655 inseminations were involved. PB resulted in longer duration of fertility (MDp = 8.1 v.MDc = 6.4 days). Heritability (h2) was higher for MDp (estimate ± s.e.: 0.27 ± 0.04) than for MDc (0.15 ± 0.04), but both traits were highly correlated with each other (rgpc = 0.85 ± 0.07). Fp and Fc had similar heritability (h2 around 0.24) and displayed a high genetic correlation (0.78 ± 0.07). The same was true for Hp and Hc (h2 around 0.17 and rgpc = 0.88 ± 0.05). The heritability estimates were 0.24 ± 0.03 for F2,12p and 0.20 ± 0.04 for F2,12c, with a 0.80 ± 0.07 genetic correlation between each other. Permanent environmental effects influenced MDp far less than MDc, Fp less than Fc, but Hp and Hc to the same extent. The high values for rgpc (>0.78) indicated that the same genes are involved in the duration of fertility for both PB and CB. Unlike CB, initial fertility for PB (F2,4p) was not correlated to overall fertility rate and to duration of fertility and probably involves different genes, if any. In both breeding schemes, indirect selection on F would be better than direct selection on H to improve H, and easier to implement than selection on MD. Moreover, any gain in one breeding scheme will have its correlated counterpart in the other one, because of the high values of rgpc.

Personal navigation has grown rapidly with the introduction of ubiquitous computing and the new generation of smart phones. Appropriate localisation is nowadays a central element for many applications and mobile services. However the proper estimation of the user's location remains a challenge. This paper presents an innovative concept for accurate and reliable positioning in challenging applications. It consists of three components: an absolute geographical reference, the hybridisation of complementary technologies and specific motion models. Two different applications illustrate this concept: urban displacement of blind people and guidance of firefighters. The validity of the concept is assessed with indoor experimental results. Finally the conclusion gives a prospective view of robust personal navigation.

Aims: To identify subgroups of patients with squamous cell carcinoma (SCC) of the larynx, characterized by the specific deregulation mechanism of the epidermal growth factor receptor (EGFR) gene, and to evaluate EGFR protein expression levels and correlate these with biological and clinicopathological parameters.

Materials and methods: Using tissue microarray technology, 50 formalin-fixed, paraffin-embedded primary laryngeal SCCs were cored and re-embedded into one block. Immunohistochemistry and chromogenic in situ hybridization were performed.

Results: Epidermal growth factor receptor protein over-expression was observed in 27/50 (54 per cent) cases and was statistically associated with tumour grade (p=0.028). Epidermal growth factor receptor gene alterations were identified in 5/50 (10 per cent) cases, which demonstrated amplification (n=4) and deletion (n=1). Chromosome 7 instability was detected in 8/50 (16 per cent) cases.

Conclusions: Epidermal growth factor receptor over-expression is a frequent event in SCCs, but it does not predict a specific molecular mechanism of gene deregulation for targeted therapeutic strategies via monoclonal antibodies.

Textural and mineralogical features in the high-K calc-alkaline Kozárovice granodiorite (Hercynian Central Bohemian Pluton, Bohemian Massif) and associated small quartz monzonite masses imply that mixing between acid (granodioritic) and basic (monzonitic/monzogabbroic) magmas was locally petrogenetically significant.

Net veining, with acicular apatite and numerous lath-shaped plagioclase crystals present in the quartz monzonite, and abundant mafic microgranular enclaves (MME) in the granodiorite, indicate that as the monzonitic magma was injected into the granodioritic magma chamber, it rapidly cooled and was partly disintegrated by the melt already present. Evidence from cathodoluminescence suggests that the two magmas exchanged early-formed plagioclase crystals. In the quartz monzonite, granodiorite-derived crystals were overgrown by narrow calcic zones, followed by broad, normally zoned sodic rims. In the granodiorite, plagioclase crystals with calcic cores overgrown by normally zoned sodic rims are interpreted as xenocrysts from the monzonite. After thermal adjustment, crystallisation of the monzonitic magma ceased relatively slowly, forming quartz and K-feldspar oikocrysts.

Although the whole-rock geochemistry of the quartz monzonite and the MME support magma mixing, major- and trace-element based modelling of the host granodiorite has previously indicated an origin dominated by assimilation and fractional crystallisation. Magma mixing therefore seems to represent a local modifying influence rather than the primary petrogenetic process.

Plutonic complexes with interlayered mafic and silicic rocks commonly contain layers (1–50 m thick) with a chilled gabbroic base that grades upwards to dioritic or silicic cumulates. Each chilled base records the infusion of new basaltic magma into the chamber. Some layers preserve a record of double-diffusive convection with hotter, denser mafic magma beneath silicic magma. Processes of hybridisation include mechanical mixing of crystals and selective exchange of H2O, alkalis and isotopes. These effects are convected away from the boundary into the interiors of both magmas. Fractional crystallisation aad replenishment of the mafic magma can also generate intermediate magma layers highly enriched in incompatible elements.

Basaltic infusions into silicic magma chambers can significantly affect the thermal and chemical character of resident granitic magmas in shallow level chambers. In one Maine pluton, they converted resident I-type granitic magma into A-type granite and, in another, they produced a low-K (trondhjemitic) magma layer beneath normal granitic magma. If comparable interactions occur at deeper crustal levels, selective thermal, chemical and isotopic exchange should probably be even more effective. Because the mafic magmas crystallise first and relatively rapidly, silicic magmas that rise away from deep composite chambers may show little direct evidence (e.g. enclaves) of their prior involvement with mafic magma.

The ultrabasic rocks of the southern portion of the Early Tertiary Cuillin Igneous Complex, Isle of Skye, are recognised as forming a Peridotite Series s.l. and have been separated into six distinct structural–lithological units. These units range from almost pure dunite (Unit 1, at the lowest structural level), through to feldspathic peridotites and allivalites (Units 5 and 6, at the highest structural levels). Detailed field and mineralogical studies indicate that both cumulus and postcumulus processes involving ultrabasic (picritic) magmas may be identified, and that the latter processes have significantly modified many of the primary features of these rocks.

Layering, both modal and phase, is present within all six units, although it is more prominent within the higher units, especially Units 5 and 6. Differing orientations of fabrics defined by cumulus spinel and intercumulus plagioclase layers within Unit 3 indicate the important role of compaction and intercumulus melt migration. Unit 4 is extremely heterogeneous, involving material ranging in composition from peridotite to allivalite, and provides clear evidence for postcumulus melt movement, magma-mixing, disruption and brecciation. Units 5 and 6 developed with a more porous cumulus framework, giving rise to dendritic growths involving cumulus olivine and poikilitic plagioclase.

It is concluded that postcumulus melt movement, injection and magma-mixing, involving ultrabasic magmas, were significant processes in the formation of the ultrabasic rocks of the Cuillin Igneous Complex.

When basaltic magma is emplaced into continental crust, melting and generation of granitic magma can occur. We present experimental and theoretical investigations of the fluid dynamical and heat transfer processes at the roof and floor of a basaltic sill in which the wall rocks melt. At the floor, relatively low density crustal melt rises and mixes into the overlying magma, which would form hybrid andesitic magma. Below the roof the low-density melt forms a stable layer with negligible mixing between it and the underlying hotter, denser magma. Our calculations applied to basaltic sills in hot crust predict that sills from 10-1500 m thick require only 2-200 years to solidify, during which time large volumes of overlying layers of convecting silicic magma are formed. These time scales are very short compared with the lifetimes of large silicic magma systems of around 106 years, and also with the time scale of 107 years for thermal relaxation of the continental crust. An important feature of the process is that crystallisation and melting occur simultaneously, though in different spots of the source region. The granitic magmas formed are thus a mixture of igneous phenocrysts and lesser amounts of restite crystals. Several features of either plutonic or volcanic silicic systems can be explained without requiring large, high-level, long-lived magma chambers.