This article presents a domain-specific language for writing highly structured multilevel system specifications. The language effectively bridges the gap between requirements engineering and systems architecting by enabling the direct derivation of a dependency graph from the system specifications. The dependency graph allows for the easy manipulation, visualization and analysis of the system architecture, ensuring the consistency among written system specifications and visual system architecture models. The system architecture models provide direct feedback on the completeness of the system specifications. The language and associated tooling has been made publicly available and has been applied in several industrial case studies. In this article, the fundamental concepts and way of working of the language are explained using an illustrative example.

Accelerating COVID-19 Treatment Interventions and Vaccines (ACTIV) was initiated by the US government to rapidly develop and test vaccines and therapeutics against COVID-19 in 2020. The ACTIV Therapeutics-Clinical Working Group selected ACTIV trial teams and clinical networks to expeditiously develop and launch master protocols based on therapeutic targets and patient populations. The suite of clinical trials was designed to collectively inform therapeutic care for COVID-19 outpatient, inpatient, and intensive care populations globally. In this report, we highlight challenges, strategies, and solutions around clinical protocol development and regulatory approval to document our experience and propose plans for future similar healthcare emergencies.

The authors seek to design a lower limb exoskeleton to augment human finned swimming; however, data associated with human finned swimming previously did not exist, particularly data that characterizes the active joint torque requirements for human-scale finned swimming motion and the corresponding thrust generation. Since these data are not directly measurable nor easily computed in human subject experiments, the authors instead employed a human-scale robotic platform to characterize the relationship between joint torque, speed, power, and thrust production during flutter kick swimming, specifically at the hip joints. Among the useful insights from this study: (1) the underwater environment can be accurately modeled as a simple viscous load as seen by the hip joints, where viscous coefficient depends on the type of fin; (2) accordingly, for a given fin, movement at any amplitude and frequency is invariant when motion is normalized by amplitude; velocity and torque by the product of amplitude and frequency; and power and thrust by the square of the product of amplitude and frequency; (3) the power-specific thrust is invariant, regardless of fin type, amplitude of motion, and frequency of motion; and 4) the phasing between right and left legs does not have a significant effect on thrust generation (i.e., kicking in-phase and kicking in opposition behave similarly). The authors hope this data will be useful to other researchers interested in developing lower limb exoskeletons to augment underwater human finned swimming.

Soft robotic devices are designed for applications such as exploration, manipulation, search and rescue, medical surgery, rehabilitation, and assistance. Due to their complex kinematics, various and often hard-to-define degrees of freedom, and nonlinear properties of their material, designing and operating these devices can be quite challenging. Using tools such as optimization methods can improve the efficiency of these devices and help roboticists manufacture the robots they need. In this work, we present an extensive and systematic literature search on the optimization methods used for the mechanical design of soft robots, particularly focusing on literature exploiting evolutionary computation (EC). We completed the search in the IEEE, ACM, Springer, SAGE, Elsevier, MDPI, Scholar, and Scopus databases between 2009 and 2024 using the keywords “soft robot,” “design,” and “optimization.” We categorized our findings in terms of the type of soft robot (i.e., bio-inspired, cable-driven, continuum, fluid-driven, gripper, manipulator, modular), its application (exploration, manipulation, surgery), the optimization metrics (topology, force, locomotion, kinematics, sensors, and energy), and the optimization method (categorized as EC or non-EC methods). After providing a road map of our findings in the state of the art, we offer our observations concerning the implementation of the optimization methods and their advantages. We then conclude our paper with suggestions for future research.

Traction of the head-neck is important in the treatment of patients suffering from neck pain due to degeneration of the intervertebral discs. Conventional neck traction is provided manually by experienced physical therapists who maintain a desired orientation of the head-neck relative to the trunk while applying the traction. It is postulated that innovative designs of neck exoskeletons can provide the same function both flexibly and accurately. This article presents a novel architecture of a parallel mechanism whose base sits on the human shoulders with 4 parallel chains, each chain having a revolute-revolute-universal-revolute (RRUR) structure, while the end-effector is connected rigidly to the human head. Each chain has five degrees-of-freedom (DOF) and applies a constraint on the motion of the end-effector. As a result, this parallel mechanism allows two DOFs to the end-effector. These are (i) forward flexion or lateral bending of the head and (ii) vertical translation. An important motivation for the current design with RRUR structure is to characterize the range of forward flexion/lateral bending of the head-neck with this structure and the vertical translation to the end-effector. A physical prototype was constructed and tested to evaluate the performance of this mechanism in hardware for the proposed application.

Prostate cancer is the second most common malignancy in American men. High-dose-rate brachytherapy is a popular treatment technique in which a large, localized radiation dose is used to kill cancer. Utilization of curvilinear catheter implantation inside the prostate gland to provide access channels to host the radiation source has shown superiority in terms of improved dosimetric constraints compared to straight needles. To this aim, we have introduced an active needle to curve inside the prostate conformal to the patient’s specific anatomical relationship for improved dose distribution to the prostate and reduced toxicity to the organs at risk. This work presents closed-loop control of our tendon-driven active needle in water medium and air using the position feedback of the tip obtained in real time from an ultrasound (US) or an electromagnetic (EM) tracking sensor, respectively. The active needle consists of a compliant flexure section to realize bending in two directions via actuation of two internal tendons. Tracking errors using US and EM trackers are estimated and compared. Results show that the bending angle of the active needle could be controlled using position feedback of the US or the EM tracking system with a bending angle error of less than 1.00 degree when delay is disregarded. It is concluded that the actuation system and controller, presented in this work, are able to realize a desired bending angle at the active needle tip with reasonable accuracy paving the path for tip tracking and manipulation control evaluations in a prostate brachytherapy.

The washing of synthetic materials has been named as the largest contributor of microplastic pollution to our oceans. With the consumption of petrochemical-based synthetic materials expected to grow, due to an increased demand, the release of microplastic fibres to our environments is expected to also accelerate. To combat microplastic fibre release, this study explores source-directed interventions within the design and manufacturing process of textiles to reduce the amount of pollution released from the surface and the edges of the fabric structure. Using standardised wash tests and polyester fabric swatches that were created in-house with systematic structural adjustments, single jersey knit fabrics were shown to release over three times more microplastic pollution than twill woven fabric. This illustrates that increasing the tightness of a fabric could be implemented within the design of fabrics for environmental benefits. Additionally, the laser cutting technique reduced microplastic fibres released by over a third compared to scissor cutting and overlock serging, showing that the edge of the fabric is a significant source of microplastic pollution released during laundering. This research highlights the adaptable and innovative eco-design approaches to clothing production which is necessary to help the sector reach international sustainability targets and regulations.

Sustainable service-product systems (SPSSs) aided packaging-free shopping are expected to promote sustainable behaviour through enhanced user experience. Yet, understanding about this kind of practice is scarce. In this study, we adopted a qualitative approach through observations and semi-structured interviews with fifteen young consumers. The results present three stages of the practice and identify the challenges in each stage, using the practice theory as a theoretical basis. In light of these, the future offerings of SPSSs are proposed.

This paper presents the design and validation of a wearable shoulder exoskeleton robot intended to serve as a platform for assistive controllers that can mitigate the risk of musculoskeletal disorders seen in workers. The design features a four-bar mechanism that moves the exoskeleton’s center of mass from the upper shoulders to the user’s torso, dual-purpose gravity compensation mechanism located inside the four-bar’s linkages that supports the full gravitational loading from the exoskeleton with partial user’s arm weight compensation, and a novel 6 degree-of-freedom (DoF) compliant misalignment compensation mechanism located between the end effector and the user’s arm to allow shoulder translation while maintaining control of the arm’s direction. Simulations show the four-bar design lowers the center of mass by $ 11 $ cm and the kinematic chain can follow the motion of common upper arm trajectories. Experimental tests show the gravity compensation mechanism compensates gravitational loading within $ \pm 0.5 $ Nm over the range of shoulder motion and the misalignment compensation mechanism has the desired 6 DoF stiffness characteristics and range of motion to adjust for shoulder center translation. Finally, a workspace admittance controller was implemented and evaluated showing the system is capable of accurately reproducing simulated impedance behavior with transparent low-impedance human operation.

Orthotic wrist supports will be beneficial for people with muscular weakness to keep their hand in a neutral rest position and prevent potential wrist contractures. Compensating the weight of the hands is complex since the level of support depends on both wrist and forearm orientations. To explore simplified approaches, two different weight compensation strategies (constant and linear) were compared to the theoretical ideal sinusoidal profile and no compensation in eight healthy subjects using a mechanical wrist support system. All three compensation strategies showed a significant reduction of 47–53% surface electromyography activity in the anti-gravity m. extensor carpi radialis. However, for the higher palmar flexion region, a significant increase of 44–61% in the m. flexor carpi radialis was found for all compensation strategies. No significant differences were observed between the various compensation strategies. Two conclusions can be drawn: (1) a simplified torque profile (e.g., constant or linear) for weight compensation can be considered as equally effective as the theoretically ideal sinusoidal profile and (2) even the theoretically ideal profile provides no perfect support as other factors than weight, such as passive joint impedance, most likely influence the required compensation torque for the wrist joint.