In 1914, an epidemic of bubonic plague ravaged colonial Dakar. The panicked French colonial administration blamed the native population and evicted indigenous Africans from the city center before burning their homes. The Dakarois fought back through a general strike, political maneuvering, and, finally, by taking to the streets. Out of this year of disease, politics, racism, and resistance came the new, segregated neighborhood of Médina, which was created to house the displaced African population of Dakar. Over the twentieth century, as Dakar swelled into a metropolis around it, Médina was a unique space in the Senegalese capital—a hotbed of cultural creativity, a crossroads for waves of migrants, and a potent and enduring contrast with the nearby downtown, known as the Plateau. This article explores the ways in which the plague of 1914 reshaped Dakar and left a lasting impression on a century of Senegalese cultural production.