The twenty years following the Second World War saw great changes in the research interests of the Observatory at Mount Stromlo, with the early emphasis on solar and geophysical phenomena giving way to stellar and galactic astrophysics. This paper traces the development of the astrophysical research work during the directorships of Woolley, who initiated the change of direction, and of Bok, who continued it. Apart from the shift in the Observatory’s research interests, these years were distinguished by (i) an outstanding period of telescope acquisition, which saw the commissioning of the 74 inch reflector, the 50 inch (formerly the Great Melbourne Telescope), the Yale/Columbia refractor (relocated from South Africa), and the Uppsala Schmidt; (ii) an Australia-wide site-testing programme and the consequent establishment of Siding Spring Observatory with the 40 inch, 24 inch and 16 inch reflectors (the site has subsequently, of course, also become the home of the Anglo-Australian Telescope, the U.K. Schmidt, and the ANU 2.3 m Advanced Technology Telescope); (iii) the incorporation of several major technological developments into the instrument complement of the Observatory, including photo-electric photometry, coudé spectroscopy, spectrum scanners, polarization instruments, and digital computers; (iv) the establishment of the link with the Australian National University and the consequent transformation of the Commonwealth Observatory into the Mount Stromlo Observatory; and (v) the setting up of a large and vigorous graduate school, comprising, at Bok’s departure, about fifteen PhD students on course.