I published in the Brit. Med. Jour., December 12, 1885, a method invented by me for the easy and yet accurate estimation of uric acid. The method consists in precipitating the uric acid as a silver salt, estimating the silver, and calculating the uric acid from the silver (168 uric acid to 108 silver). As no process was then invented which had itself been tested, except as Salkowski's, by the side of others acknowledged to be inexact, I did all my work with weighed quantities of uric acid, and tested my process—the only straightforward way of working—by adding known quantities of uric acid to one of two samples of a urine, and finding as a result of my estimations of the uric acid in the two samples practically the same difference as the weight of acid added. Hermann confirms my work (Zeitsch. f. physiol. Chemie, Bd. xii. s. 496), and Czapek, working with Professor Huppert, proposes a modification of my method, while Camerer's results (Zeitsch. f. Biologie, Bd. xxvii. s. 113) run on parallel lines. My results have been adversely criticised by Salkowski, who still maintains that uric acid and silver do not combine in a definite ratio. This observer published in 1872 twelve analyses, which show, according to his belief, that there is no constancy in the proportion between the silver and uric acid, and in 1889 he again affirms the same thing, bringing forward in proof of his assertion some dozen analyses made by his colleague Professor Jolin and himself. I was for some time unwilling to take up the controversy where Professor Salkowski had left it, for, certain of the care with which my own work had been done, I was quite willing to let the matter be settled by other and less prejudiced persons, especially as such seemed willing enough to undertake the task. As, however, my method had been widely used, especially for clinical purposes, and as I had frequently to answer queries concerning its accuracy, I felt it my duty carefully to examine once more the whole question, and if there was any doubt about it, at once to set that doubt at rest. I was I confess agreeably surprised to find that Professor Salkowski had made a slight mistake, which when rectified places his own results and mine in complete accord. In order to make this point quite clear I will venture to reproduce Professor Salkowski's results, arranging his analyses in order, beginning with the one having the least uric acid.