Hostname: page-component-586b7cd67f-2brh9 Total loading time: 0 Render date: 2024-11-22T23:10:21.077Z Has data issue: false hasContentIssue false
  • English
  • Français

Carotenoids: functions and fallacies

Published online by Cambridge University Press:  28 February 2007

David I. Thurnham
David I. Thurnham
Affiliation:
Human Nutrition Research Group, Department of Biology and Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland
Rights & Permissions [Opens in a new window]

Abstract

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Symposium on ‘Antioxidants’
Information
Proceedings of the Nutrition Society , Volume 53 , Issue 1 , March 1994 , pp. 77 - 87
Copyright
Copyright © The Nutrition Society 1994

References

Bendich, A. (1991). β-Carotene and the immune response. Proceedings of the Nutrition Society 50, 263–274.CrossRefGoogle ScholarPubMed
Bieri, J. G., Brown, E. D. & Smith, J. C. Jr (1985). Determination of individual carotenoids in human plasma by high performance chromatography. Journal of Liquid Chromatography 8, 473–484.CrossRefGoogle Scholar
Burton, G. W. & Ingold, K. U. (1984). β-carotene: an unusual type of lipid antioxidant. Science 224, 569–573.CrossRefGoogle ScholarPubMed
Cantilena, L. R., Stukel, T. A., Greenberg, E. R., Nann, S. & Nierenberg, D. W. (1992). Diurnal and seasonal variation of five carotenoids measured in human serum. American Journal of Clinical Nutrition 55, 659–663.CrossRefGoogle ScholarPubMed
Carew, T. E., Schwenke, D. C. & Steinberg, D. (1987). Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: Evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit. Proceedings of the National Academy of Sciences, USA 84, 7725–7729.CrossRefGoogle ScholarPubMed
Chopra, M., Puhl, H. & Thurnham, D. I. (1993 a). Effect of lutein on copper initiated oxidation of low density lipoproteins. Proceedings of the International Life Sciences Institute, Europe, p. 92 Abstr.Google Scholar
Chopra, M. & Thurnham, D. I. (1994). Effect of lutein on oxidation of low-density lipoproteins (LDL) in vitro. Proceedings of the Nutrition Society 53, (In the Press).Google Scholar
Chopra, M., Willson, R. L. & Thurnham, D. I. (1993 b). Free radical scavenging activity of lutein in vitro. In Proceedings of the New York Academy of Sciences Conference, pp. 353–356 [Cranfield, L. M., Olson, J. A. and Krinsky, N. I., editors]. New York: NY Academy of Sciences.Google Scholar
Connett, J. E., Kuller, L. H., Kjelsberg, M. O., Polk, B. F., Collins, G., Rider, A. & Hulley, S. B. (1989). Relationship between carotenoids and cancer. The multiple risk factor intervention trial (MRFIT) study. Cancer 64, 126–134.3.0.CO;2-H>CrossRefGoogle ScholarPubMed
Cooney, R. V., Bertram, J. S., Hankin, J. H., Kolonel, L. N., Miyake, A., Billings, K. & Bourne, W. (1991). Relationship between dietary, serum, and tissue levels of carotenoids. Cancer Letters 61, 81–87.CrossRefGoogle ScholarPubMed
Culling-Berglund, A. J., Newcomb, S. A., Gagne, M., Morfitt, W. S. & Davis, T. P. (1989). A sensitive and specific procedure for analysis of β-carotene in human skin. Journal of Micronutrient Analysis 5, 139–148.Google Scholar
Dieber-Rotheneder, M., Puhl, H., Waeg, G., Striegl, G. & Esterbauer, H. (1991). Effect of oral supplementation with D-α-tocopherol on the vitamin E content of human low density lipoprotein and resistance to oxidation. Journal of Lipid Research 32, 1325–1332.CrossRefGoogle ScholarPubMed
Esterbauer, H., Dieber-Rotheneder, M., Striegl, G. & Waeg, G. (1991). The role of vitamin E in preventing the oxidation of low-density lipoproteins. American Journal of Clinical Nutrition 53, 314S–321S.CrossRefGoogle Scholar
Esterbauer, H., Dieber-Rotheneder, M., Waeg, G., Striegl, G. & Jurgens, G. (1990). Biochemical, structural and functional properties of oxidised low-density lipoprotein. Chemical Research in Toxicology 3, 77–92.CrossRefGoogle Scholar
Foote, C. S. & Denny, R. W. (1968). Chemistry of singlet oxygen. VII. Quenching by β-carotene. Journal of American Chemical Society 90, 6233–6235.CrossRefGoogle Scholar
Garewal, H. & Shamdas, G. J. (1991). Intervention trials with beta-carotene in precancerous conditions of the upper aerodigestive tract. In Micronutrients in Health and Disease, pp. 127–140 [Bendich, A. and Butterworth, C. E., editors]. New York: Dekker.Google Scholar
Gaziano, J. M., Manson, J. E., Ridker, P. M., Buring, J. E. & Hennekens, C. H. (1990). Beta carotene therapy for chronic stable angina. Circulation 82, Suppl. III, 201.Google Scholar
Gollnick, H., Hemmes, C., Tillmann, R., Chun, S. C., Sundermeir, K., Hopfenmuller, U. & Biesalski, H. K. (1993). Beta-carotene supplementation and sun-induced alterations of the erythema response in human skin. Proceedings of the International Life Sciences Institute, Europe, pp. 88–89 Abstr.Google Scholar
Greenberg, E. R., Baron, J. A., Stukel, T. A., Stevens, M. M., Mandel, J. S., Spencer, S. K., Elias, P. M., Lowe, N., Nierenberg, D. W., Bayrd, G., Corwin Vance, J., Freeman, D. H. Jr., Clendenning, W. E., Kwan, T. & Skin Cancer Prevention Group (1990). A clinical trial of beta carotene to prevent basal-cell and squamous-cell cancers of the skin. New England Journal of Medicine 323, 789–795.CrossRefGoogle ScholarPubMed
Gregory, J., Foster, K., Tyler, H. & Wiseman, M. (1990). The Dietary and Nutritional Survey of British Adults. London: H.M. Stationery Office.Google Scholar
Handelman, G. J., Dratz, E. A., Reay, C. C. & Van Kuijk, J. G. M. (1988). Carotenoids in the human macula and whole retina. Investigative Ophthalmology & Visual Science 29, 850–855.Google ScholarPubMed
Handelman, G. J., Snodderly, D. M., Krinsky, N. I., Russett, M. D. & Adler, A. J. (1991). Biological control of primate macular pigment. Investigative Ophthalmology & Visual Science 32, 257–267.Google ScholarPubMed
Hennekens, C. H. (1986). Micronutrients and cancer prevention. New England Journal of Medicine 315, 1288–1289.CrossRefGoogle ScholarPubMed
Horwitt, M. K., Harvey, C. C., Dahm, C. H. & Searcy, M. T. (1972). Relationship between tocopherol and serum lipid levels for the determination of nutritional adequacy. Annals of the New York Academy of Sciences 203, 223–236.CrossRefGoogle ScholarPubMed
Jialal, I. & Grundy, S. M. (1991). Preservation of the endogenous antioxidants in low density lipoprotein by ascorbate but not probucol during oxidative modification. Journal of Clinical Investigation 87, 597–601.CrossRefGoogle Scholar
Kaplan, L. A., Lau, J. M. & Stein, E. A. (1990). Carotenoid composition, concentrations and relationships in various human organs. Clinical Physiology and Biochemistry 8, 1–10.Google ScholarPubMed
Krinsky, N. I. (1991). Effects of carotenoids in cellular and animal systems. American Journal of Clinical Nutrition 53, 238S–246S.CrossRefGoogle ScholarPubMed
Krinsky, N. I., Cornwell, D. G. & Oncley, J. L. (1958). The transport of vitamin A and carotenoids in human plasma 73, 233–246.Google ScholarPubMed
Lavy, A., Ben Amotz, A. & Aviram, M. (1992). Preferential inhibition of LDL oxidation by the all-trans isomer of β-carotene in comparison with 9-cis β-carotene. European Journal of Clinical Chemistry and Clinical Biochemistry 31, 83–90.Google Scholar
Mathews-Roth, M. M. (1975). Presence of carotenoids in the erythrocyte membranes for carotenaemic and non-carotenaemic individuals. Clinical Chemistry 21, 258–259.CrossRefGoogle ScholarPubMed
Mathews-Roth, M. M. (1978). Carotenoids in the leukocytes of carotenaemic and non-carotenaemic individuals. Clinical Chemistry 24, 700–701.CrossRefGoogle ScholarPubMed
Mathews-Roth, M. M., Pathak, M. A., Fitzpatrick, T. B., Harber, L. C. & Kass, E. H. (1977). Beta-carotene therapy for erythropoietic protoporphyria and other photosensitive diseases. Archives of Dermatology 113, 1229–1232.CrossRefGoogle Scholar
Mathews-Roth, M. M., Wilson, T., Fujimore, E. & Krinsky, N. I. (1974). Carotenoid chromophore length and protection against photosensitization. Photochemistry and Photobiology 19, 217–222.CrossRefGoogle ScholarPubMed
Moon, R. C. (1989). Comparative aspects of carotenoids and retinoids as chemopreventive agents for cancer. Journal of Nutrition 119, 127–134.CrossRefGoogle ScholarPubMed
Mordi, R. C. (1993). Carotenoids: functions and degradation. Chemistry and Industry issue 3, 79–83.Google Scholar
Morel, D. W., Hessler, J. R. & Chisholm, G. M. (1983). Low density-lipoprotein cytotoxicity induced by free radical peroxidation of lipid. Journal of Lipid Research 24, 1070–1076.CrossRefGoogle ScholarPubMed
Olson, J. A. (1989). Provitamin A function of carotenoids: the conversion of β-carotene into vitamin A. Journal of Nutrition 119, 105–108.CrossRefGoogle ScholarPubMed
Parker, R. S. (1988). Carotenoid and tocopherol composition of human adipose tissue. American Journal of Clinical Nutrition 47, 33–36.CrossRefGoogle ScholarPubMed
Peto, R., Doll, R., Buckley, J. D. & Sporn, M. B. (1981). Can dietary beta-carotene materially reduce human cancer rates? Nature 290, 201–208.CrossRefGoogle ScholarPubMed
Princen, H. M. G., Van Poppel, G., Vogelezang, C., Buytenhek, R. & Kok, F. J. (1992). Supplementation with vitamin E but not β-carotene in vivo protects low density lipoprotein from lipid peroxidation in vitro. Effect of cigarette smoking. Arteriosclerosis and Thrombosis 12, 554–562.CrossRefGoogle Scholar
Regnstrom, J., Nilsson, J., Tornvall, P., Landou, C. & Hamsten, A. (1992). Susceptibility to low-density lipoprotein oxidation and coronary atherosclerosis in man. Lancet 339, 1183–1186.CrossRefGoogle ScholarPubMed
Schmitz, H. H., Poor, C. L., Wellman, R. B. & Erdman, J. W. Jr (1991). Concentrations of selected carotenoids and vitamin A in human liver, kidney and lung tissue. Journal of Nutrition 121, 1613–1621.CrossRefGoogle ScholarPubMed
Stich, H. F., Rosin, M. P., Hornby, A. P., Mathew, B., Sankaranarayanan, R. & Krishnan Nair, M. (1988). Remission of oral leukoplakias and micronuclei in tobacco/betel quid chewers treated with beta-carotene and with beta-carotene plus vitamin A. International Journal of Cancer 42, 195–199.CrossRefGoogle ScholarPubMed
Stich, H. F., Stich, W., Rosin, M. P. & Vallejera, M. O. (1984). Use of the micronucleus test to monitor the effect of vitamin A, beta-carotene and canthaxanthin on the buccal mucosa of betel nut/tobacco chewers. International Journal of Cancer 34, 745–750.CrossRefGoogle ScholarPubMed
Stryker, W. S., Kaplan, L. A., Stein, E. A., Stampfer, M. J., Sober, A. & Willett, W. C. (1988). The relation of diet, cigarette smoking, and alcohol consumption to plasma beta-carotene and alpha-tocopherol levels. American Journal of Epidemiology 127, 283–296.CrossRefGoogle ScholarPubMed
Terao, J. (1989). Antioxidant activity of β-carotene-related carotenoids in solution. Lipids 24, 659–661.CrossRefGoogle ScholarPubMed
Thompson, J. N., Duval, S. & Verdier, P. (1985). Investigation of carotenoids in human blood using high-performance liquid chromatography. Journal of Micronutrient Analysis 1, 81–91.Google Scholar
Thurnham, D. I. (1989). Lutein, cholesterol, and risk of cancer. Lancet ii, 441–442.CrossRefGoogle Scholar
Thurnham, D. I. (1990). Anti-oxidant vitamins and cancer prevention. Journal of Micronutrient Analysis 7, 279–299.Google Scholar
Thurnham, D. I. (1993). Chemical aspects and biological mechanisms of anti-cancer nutrients in plant foods. In Food and Cancer Prevention, pp. 109–118 [Waldron, K. W., Johnson, I. T. and Fenwick, G. R., editors]. London: Royal Society of Chemistry.Google Scholar
Thurnham, D. I., Chopra, M. & Leake, D. (1993). A role for lutein in influencing oxidation of low density lipoprotein. Irish Journal of Medical Science (In the Press).Google Scholar
Thurnham, D. I. & Flora, P. S. (1988). Do higher vitamin A requirements in men explain the difference between the sexes in plasma provitamin A carotenoids and retinol. Proceedings of the Nutrition Society 47, 181A.Google Scholar
Thurnham, D. I. & Tyler, H. A. (1990). Factors influencing plasma carotenoids in British adults. Ninth International Symposium on Carotenoids A6–2, p. 27 Abstr.Google Scholar
van Hinsbergh, V. W., Scheffer, M., Havekas, L. & Kempen, H. J. (1986). Role of endothelial cells and their products in the modification of low density lipoprotein. Biochimica et Biophysica Acta 878, 49–64.CrossRefGoogle Scholar
Wang, X.-D., Tang, G.-W., Fox, J. G., Krinsky, N. I. & Russell, R. M. (1991). Enzymic conversion of β-carotene in β-apocarotenals and retinoids by human, monkey, ferret, and rat tissues. Archives of Biochemistry and Biophysics 285, 8–16.CrossRefGoogle Scholar
Winklhofer-Roob, B. M., Puhl, H., Schmerling, D. H. & Esterbauer, H. (1993). Improved oxidation resistance of low-density lipoproteins of cystic fibrosis patients after efficient beta-carotene supplementation. Proceedings of the International Life Sciences Institute, Europe, p. 116 Abstr.Google Scholar