As the seventeenth century progressed, there was a growing realization among those who reflected on the kind of knowledge the new sciences could afford (among them Kepler, Bacon, Descartes, Boyle, Huygens) that hypothesis would have to be conceded a much more significant place in natural philosophy than the earlier ideal of demonstration allowed. Then came the mechanics of Newton's Principia, which seemed to manage quite well without appealing to hypothesis (though much would depend on how exactly terms like “force” and “attraction” were construed). If the science of motion could dispense with causal hypothesis and the attendant uncertainty, why should this not serve as the goal of natural philosophy generally? The apparent absence of causal hypothesis from the highly successful new science of motion went far towards shaping, in different ways, the account of scientific knowledge given by many of the philosophers of the century following, notable among them Berkeley, Hume, Reid, and Kant. This “Newtonian” interlude in the history of the philosophy of science would today be accounted on the whole a byway. The Principia, despite its enormous achievement in shaping subsequent work in mechanics, was from the beginning too idiosyncratic from an epistemic standpoint to serve as model for the natural sciences generally.

P. Kyle Stanford (2000) attempts to offer a truth-linked explanation of the success of science which, he thinks, can be welcome to antirealists. He proposes an explanation of the success of a theory T1 in terms of its predictive similarity to the true theory T of the relevant domain. After raising some qualms about the supposed antirealist credentials of Stanford's account, I examine his explanatory story in some detail and show that it fails to offer a satisfactory explanation of the success of science.

Both Representation Theorem Arguments and Dutch Book Arguments support taking probabilistic coherence as an epistemic norm. Both depend on connecting beliefs to preferences, which are not clearly within the epistemic domain. Moreover, these connections are standardly grounded in questionable definitional/metaphysical claims. The paper argues that these definitional/metaphysical claims are insupportable. It offers a way of reconceiving Representation Theorem arguments which avoids the untenable premises. It then develops a parallel approach to Dutch Book Arguments, and compares the results. In each case preference-defects serve as a diagnostic tool, indicating purely epistemic defects.

John Maynard Smith has defended against philosophical criticism the view that developmental biology is the study of the expression of information encoded in the genes by natural selection. However, like other naturalistic concepts of information, this “teleosemantic” concept is equally applicable to many non-genetic factors in development. Maynard Smith also fails to show that developmental biology is concerned with teleosemantic information. Some other ways to support Maynard Smith's conclusion are considered. It is argued that on any definition of information the view that development is the expression of genetic information is misleading. Some reasons for the popularity of that view are suggested.