Hostname: page-component-586b7cd67f-g8jcs Total loading time: 0 Render date: 2024-11-30T23:38:27.106Z Has data issue: false hasContentIssue false
  • English
  • Français

Immune response of guinea-pigs to chemically abbreviated prepatent Metastrongylus apri infection

Published online by Cambridge University Press:  06 April 2009

V. Kumar  and
J. Mortelmans
V. Kumar
Affiliation:
Department of Veterinary Medicine, Institute of Tropical Medicine, 155-Nationalestraat, B 2000 Antwerpen, Belgium
J. Mortelmans
Affiliation:
Department of Veterinary Medicine, Institute of Tropical Medicine, 155-Nationalestraat, B 2000 Antwerpen, Belgium
Get access Rights & Permissions [Opens in a new window]

Summary

The effect of chemical abbreviation of the primary infection dose (PID) of 160 infective larvae of Metastrongylus apri on the immune status of the guinea-pig host was studied. The criteria used for assessing the status of immunity consisted of clinical manifestations following administration of a challenge infection dose (CID) of 800 infective larvae of M. apri, the rate of worm recovery 15 days post-CID and the rate of mortality following administration of CID.

Among the guinea-pigs of the main experimental group, where 15-day-old PID was abbreviated by two parenteral doses of levamisole, a strong immunity to CID given 35 days post-PID was built-up. Against this, all the guinea-pigs of a control group, which did not receive PID, died between 16 and 22 days post-CID.

The increase in serum gamma-globulin level of the guinea-pigs, where the PID was abbreviated chemically, suggested that the rise of this globulin fraction in the serum could be in some way related to the resistant state of guinea-pigs.

Type
Research Article
Information
Parasitology , Volume 72 , Issue 1 , February 1976 , pp. 13 - 18
Copyright
Copyright © Cambridge University Press 1976

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Campbell, W. C. (1963). Attempts to demonstrate immunity to Schistosoma mansoni in mice previously subjected to chemically abbreviated infections. The Journal of Parasitology 49, 824–9.CrossRefGoogle ScholarPubMed
Dixon, J. B. (1968). Immunity to Metastrongylus apri. Veterinary Record 82, 417–8.Google Scholar
Dunn, D. R. (1954). The incidence of lungworms in pigs in north-west Britain. II. Some observations on the establishment of Metastrongylus apri in laboratory animals. Transactions of the Royal Society of Tropical Medicine and Hygiene 48, 9–10.Google Scholar
Düwel, V. D. & Schleich, H. (1971). Das Meerschweinchen-ein Modellwirt für Metastrongyliden. Berliner und Münchener Tierärztliche Wochenschrift, no. 20, 405–8.Google Scholar
Hollo, F. (1966). Investigations on metastrongylosis in swine. III. The pathogenicity of lungworms in artificially infected animals. Acta Veterinaria Academiae Scientiarum Hungaricae 16, 413–28.Google Scholar
Jaggers, S. E. & Herbert, I. V. (1968). Studies on the resistance of pigs to the lungworm Metastrongylus spp. Infection in minimal disease pigs from eight weeks of age. Journal of Comparative Pathology and Therapeutics 78, 161–72.CrossRefGoogle Scholar
Parker, W. H. & Roberts, H. E. (1958). Observations on experimental parasitic bronchitis in calves and response to diethylcarbamazine. Journal of Comparative Pathology and Therapeutics 68, 402–10.CrossRefGoogle ScholarPubMed
Schwartz, B. & Lucker, J. T. (1935). Experimental infections and superinfections of pigs with lungworms. The Journal of Parasitology 21, 432.Google Scholar
Wakelin, D. (1969). Studies on the immunity of albino mice to Trichuris muris. The stimulation of immunity by chemically abbreviated infections. Parasitology 59, 549–55.CrossRefGoogle ScholarPubMed