The system composed of a circular cylinder free to move along a transverse rectilinear path within a cross-current has often served as a canonical problem to study the vortex-induced vibrations (VIV) developing in the absence of structural restoring force, thus without structural natural frequency. The object of the present work is to extend the exploration of the behaviour of this system when the path is set to an arbitrary orientation, varying from the transverse to the streamwise direction, and the cylinder is forced to rotate about its axis. The investigation is conducted numerically at a Reynolds number equal to
$100$, based on the body diameter and oncoming flow velocity, for structure to displaced fluid mass ratios down to
$0.01$ and values of the rotation rate (ratio between body surface and oncoming flow velocities) ranging from
$0$ to
$1$. When the transverse symmetry is broken by the orientation of the trajectory or the forced rotation, the cylinder drifts along the rectilinear path, at a velocity that can be predicted by a quasi-steady approach. Three distinct regimes are encountered: a pure drift regime, where the body translates at a constant velocity, and two oscillatory regimes, characterised by contrasted forms of displacement fluctuation about the drifting motion, but both closely connected to flow unsteadiness. VIV, nearly sinusoidal, persist over a wide range of path orientations, for all rotation rates. On the other hand, irregular jumps of the body, triggered by the rotation and named saccades, emerge when the trajectory is aligned, or almost aligned, with the current. The two forms of response differ by their regularity, but also by their amplitudes and frequencies, which deviate by one or more orders of magnitude. The rotation attenuates both VIV and saccades. Yet, an increase of the rotation rate enhances the erratic nature of the saccade regime.