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High incidence of subacute sclerosing panencephalitis in South India

Published online by Cambridge University Press:  15 May 2009

V. Saha ,
T. Jacob John ,
P. Mukundan ,
C. Gnanamuthu ,
S. Prabhakar ,
G. Arjundas ,
Z. A. Sayeed ,
G. Kumaresan  and
K. Srinivas
V. Saha
Affiliation:
Departments of Virology, Christian Medical College and Hospital, Vellore
T. Jacob John*
Affiliation:
Departments of Virology, Christian Medical College and Hospital, Vellore
P. Mukundan
Affiliation:
Departments of Virology, Christian Medical College and Hospital, Vellore
C. Gnanamuthu
Affiliation:
Departments of Neurology, Christian Medical College and Hospital, Vellore
S. Prabhakar
Affiliation:
Departments of Neurology, Christian Medical College and Hospital, Vellore
G. Arjundas
Affiliation:
Institute of Neurology, Madras Medical College, Madras
Z. A. Sayeed
Affiliation:
Institute of Neurology, Madras Medical College, Madras
G. Kumaresan
Affiliation:
Institute of Neurology, Madras Medical College, Madras
K. Srinivas
Affiliation:
K. Gopalakrishna Department of Neurology, V.H.8. Medical Centre, Madras T. S. Srinivasan Department of Neurology and Research, Public Health Centre, Madras
*
*Professor T.Jacob John, Head, Department of Virology, Christian Medical College and Hospital. Vellore, India632004.
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During 19837 a clinical diagnosis of subacute sclerosing panencephalitis (SSPE) was confirmed by the detection of measles virus haemagglutination inhibiting antibody in the cerebrospinal fluid (CSF) in 81 subjects resident in Tamilnadu. The antibody titre (reciprocol of the endpoint dilution) in the CSF ranged from 2 to 32 and in the sera from 8 to 2048. The CSF: serum ratios of titres were 1:41:64 in 80 cases and 1:128 in one case. The median age at onset of SSPE was 10 years and 97% of cases were diagnosed at stage 2 and beyond. Based on the geographic distribution of 72 cases in an estimated population of 84 million, the annual incidence of SSPE was calculated to be 214 per million population, or 43 cases per million children below 20 years. Assuming that only 10% of all cases would have reached the level of laboratory diagnosis, the incidence may be as high as 21 cases per million population.

Type
Research Article
Information
Epidemiology & Infection , Volume 104 , Issue 1 , February 1990 , pp. 151 - 156
Copyright
Copyright Cambridge University Press 1990

References

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