Recombinant Antibodies for Immunotherapy

doi:10.1017/CBO9780511596773

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Edited by Melvyn Little, Affimed Therapeutics AG

Publisher:: Cambridge University Press
Online publication date:: December 2009
Print publication year:: 2009
Online ISBN:: 9780511596773
DOI:: https://doi.org/10.1017/CBO9780511596773

Subjects:: Life Sciences, Microbiology and Immunology, Biotechnology

89.99 (GBP)

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Recombinant Antibodies for Immunotherapy provides a comprehensive overview of the field of monoclonal antibodies (mAbs), a market that has grown tremendously in recent years. Twenty-five articles by experienced and innovative authors cover the isolation of specific human mAbs, humanization, immunogenicity, technologies for improving efficacy, 'arming' mAbs, novel alternative Ab constructs, increasing half-lives, alternative concepts employing non-immunoglobulin scaffolds, novel therapeutic approaches, a market analysis of therapeutic mAbs, and future developments in the field. The concepts and technologies are illustrated by examples of recombinant antibodies being used in the clinic or in development. This book will appeal to both newcomers and experienced scientists in the field, biology and biotechnology students, research and development departments in the pharmaceutical industry, medical researchers, clinicians, and biotechnology investors.

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Recombinant Antibodies for Immunotherapy

This Book has been cited by the following publications. This list is generated based on data provided by Crossref.

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Contents

Frontmatter
pp i-iv

Contents
pp v-vi

Contributors
pp vii-x

Foreword by Sir Gregory Winter
pp xi-xii

Preface
pp xiii-xiv

RECOMBINANT ANTIBODIES FOR IMMUNOTHERAPY
pp xv-xvi

PART I - HUMANIZED ANTIBODIES
pp 1-2

1 - Humanization of Recombinant Antibodies
pp 3-19

2 - Immunogenicity Assessment of Antibody Therapeutics
pp 20-42

3 - In Vitro Screening for Antibody Immunogenicity
pp 43-52

PART II - GENERATION AND SCREENING OF ANTIBODY LIBRARIES
pp 53-54

4 - Antibody Libraries from Naïve V Gene Sources
pp 55-65

5 - Antibodies from IgM Libraries
pp 66-74

6 - Generation and Screening of the Synthetic Human Combinatorial Antibody Library HuCAL GOLD
pp 75-86

PART III - TRANSGENIC HUMAN ANTIBODY REPERTOIRES
pp 87-88

7 - Therapeutic Antibodies from XenoMouse Transgenic Mice
pp 89-99

8 - VelocImmune: Immunoglobulin Variable Region Humanized Mice
pp 100-108

PART IV - ANTIBODY EFFECTOR FUNCTION
pp 109-110

9 - Mechanisms of Tumor Cell Killing by Therapeutic Antibodies
pp 111-123

10 - Optimization of Fc Domains to Enhance Antibody Therapeutics
pp 124-143

11 - Glycoengineered Therapeutic Antibodies
pp 144-154

PART V - ARMING ANTIBODIES
pp 155-156

12 - Monoclonal Antibodies for the Delivery of Cytotoxic Drugs
pp 157-173

13 - Immunotherapy with Radio-immune Conjugates
pp 174-189

14 - Immunotherapeutic Antibody Fusion Proteins
pp 190-200

PART VI - NOVEL ANTIBODY FORMATS
pp 201-202

15 - Alternative Antibody Formats
pp 203-215

16 - Single-Domain Antibodies
pp 216-230

17 - Engineering of Non-CDR Loops in Immunoglobulin Domains
pp 231-240

PART VII - ANTIGEN-BINDING REPERTOIRES OF NON-IMMUNOGLOBULIN PROTEINS
pp 241-242

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Recombinant Antibodies for Immunotherapy

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