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Chapter 1.2 - Chapter

from 1 - Inflammatory Conditions

Published online by Cambridge University Press:  06 October 2022

Anita Arsovska
Affiliation:
University of Ss Cyril and Methodius
Derya Uluduz
Affiliation:
Istanbul Üniversitesi
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Summary

Eosinophilic granulomatosis with polyangiitis (EGPA, previously named Churg– Strauss syndrome) is a form of necrotizing vasculitis occurring in patients with asthma and eosinophilia. Clinical manifestations are ranging from general symptoms like fever, arthralgias, myalgias and loss of weight, to involvement of virtually any organ system in the body. Nervous system involvement is usual and mainly concerns the peripheral nerves. Mononevritis multiplex is the most frequent finding, followed by peripheral neuropathy. Central nervous system is affected in almost 5% of patients. Ischemic stroke is a relatively rare complication of the disease. Several possible underlying mechanisms of stroke have been proposed: cardioembolism, vasculitis and/or direct eosinophilic infiltration. Given the rarity and the detrimental impact in quality of life and mortality, treatment in EGPA patients with stroke should be more aggressive in order to achieve clinical remission as quickly as possible. The mainstay of treatment is the combination of corticosteroids and immunosuppressants

Type
Chapter
Information
Rare Causes of Stroke
A Handbook
, pp. 28 - 33
Publisher: Cambridge University Press
Print publication year: 2022

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References

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  • Chapter
  • Edited by Derya Uluduz, Istanbul Üniversitesi
  • Anita Arsovska
  • Book: Rare Causes of Stroke
  • Online publication: 06 October 2022
  • Chapter DOI: https://doi.org/10.1017/9781108902793.006
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  • Chapter
  • Edited by Derya Uluduz, Istanbul Üniversitesi
  • Anita Arsovska
  • Book: Rare Causes of Stroke
  • Online publication: 06 October 2022
  • Chapter DOI: https://doi.org/10.1017/9781108902793.006
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Chapter
  • Edited by Derya Uluduz, Istanbul Üniversitesi
  • Anita Arsovska
  • Book: Rare Causes of Stroke
  • Online publication: 06 October 2022
  • Chapter DOI: https://doi.org/10.1017/9781108902793.006
Available formats
×