Rice herbicide drift poses a significant challenge in California, where rice fields are near almond, pistachio, and walnut orchards. This research was conducted as part of a stewardship program for a newly registered rice herbicide and specifically aimed to compare the onset of foliar symptoms resulting from simulated florpyrauxifen-benzyl drift with residues in almond, pistachio, and walnut leaves at several time points after exposure. Treatments were applied to one side of the canopy of 1- and 2-yr-old trees at 1/100X and 1/33X of the florpyrauxifen-benzyl rice field use rate of 29.4 g ai ha–1 in 2020 and 2021. Symptoms were observed 3 d after treatment (DAT) for pistachio and 7 DAT for almond and walnut, with peak severity at approximately 14 DAT. While almond and walnut symptoms gradually dissipated throughout the growing season, pistachio still had symptoms at leaf out in the following spring. Leaf samples were randomly collected from each tree for residue analysis at 7, 14, and 28 DAT. At 7 DAT with the 1/33X rate, almond, pistachio, and walnut leaves had florpyrauxifen-benzyl at 6.06, 5.95, and 13.12 ng g–1 fresh weight (FW) leaf, respectively. By 28 DAT, all samples from all crops treated with the 1/33X drift rate had florpyrauxifen-benzyl at less than 0.25 ng g–1 FW leaf. At the 1/100X rate, pistachio, almond, and walnut residues were 1.78, 2.31, and 3.58 ng g–1 FW leaf at 7 DAT, respectively. At 28 DAT with the 1/100X rate, pistachio and almond samples had florpyrauxifen-benzyl at 0.1 and 0.04 ng g–1 FW leaf, respectively, but walnut leaves did not have detectable residues. Together, these data suggest that residue analysis from leaf samples collected after severe symptoms may substantially underestimate actual exposure due to the relatively rapid dissipation of florpyrauxifen-benzyl in nut tree foliage.

Damage to non–dicamba resistant (non-DR) soybean [Glycine max (L.) Merr.] has been frequent in geographies where dicamba-resistant (DR) soybean and cotton (Gossypium hirsutum L.) have been grown and sprayed with the herbicide in recent years. Off-target movement field trials were conducted in northwest Arkansas to determine the relationship between dicamba concentration in the air and the extent of symptomology on non-DR soybean. Additionally, the frequency and concentration of dicamba in air samples at two locations in eastern Arkansas and environmental conditions that impacted the detection of the herbicide in air samples were evaluated. Treatment applications included dicamba at 560 g ae ha−1 (1X rate), glyphosate at 860 g ae ha−1, and particle drift retardant at 1% v/v applied to 0.37-ha fields with varying degrees of vegetation. The relationship between dicamba concentration in air samples and non-DR soybean response to the herbicide was more predictive with visible injury (generalized R 2 = 0.82) than height reduction (generalized R 2 = 0.43). The predicted dicamba air concentration resulting in 10% injury to soybean was 1.60 ng m−3 d−1 for a single exposure. The predicted concentration from a single exposure to dicamba resulting in a 10% height reduction was 3.78 ng m−3 d−1. Dicamba was frequently detected in eastern Arkansas, and daily detections above 1.60 ng m−3 occurred 17 times in the period sampled. The maximum concentration of dicamba recorded was 7.96 ng m−3 d−1, while dicamba concentrations at Marianna and Keiser, AR, were ≥1 ng m−3 d−1 in six samples collected in 2020 and 22 samples in 2021. Dicamba was detected consistently in air samples collected, indicating high usage in the region and the potential for soybean damage over an extended period. More research is needed to quantify the plant absorption rate of volatile dicamba and to evaluate the impact of multiple exposures of gaseous dicamba on non-targeted plant species.

In current and next-generation weed control technologies, sequential applications of contact and systemic herbicides for postemergence control of troublesome weeds are needed to mitigate the evolution of herbicide resistance. A clear understanding of the impact auxin herbicide symptomology has on Palmer amaranth groundcover will aid optimization of sequential herbicide applications. Field and greenhouse experiments were conducted in Fayetteville, AR, and a laboratory experiment was conducted in Lonoke, AR, in 2020 to evaluate changes in Palmer amaranth groundcover following an application of 2,4-D and dicamba with various nozzles, droplet sizes, and velocities. Field experiments utilized three nozzles: Extended Range (XR), Air Induction Extended Range (AIXR), and Turbo TeeJet® Induction (TTI), to assess the effect of spray droplet size on changes in Palmer amaranth groundcover. Nozzle did not affect Palmer amaranth groundcover when dicamba was applied. However, nozzle selection did impact groundcover when 2,4-D was applied; the following nozzle order XR > AIXR > TTI reduced Palmer amaranth groundcover the most in both site-years of the field experiment. This result (XR > AIXR > TTI) matches percent spray coverage data for 2,4-D and is inversely related to spray droplet size data. Rapid reductions of Palmer amaranth groundcover from 100% at time zero to 39.4% to 64.1% and 60.0% to 85.8% were observed 180 min after application in greenhouse and field experiments, respectively, regardless of herbicide or nozzle. In one site-year of the greenhouse and field experiments, regrowth of Palmer amaranth occurred 10,080 min (14 d) after an application of either 2,4-D or dicamba to larger than labeled weeds. In all experiments, complete reduction of live Palmer amaranth tissue was not observed 21 d after application with any herbicide or nozzle combination. Control of Palmer amaranth escapes with reduced groundcover may potentially lead to increased selection pressure on sequentially applied herbicides due to a reduction in spray solution contact with the targeted pest.

Infant siblings of children with autism spectrum disorder (ASD) exhibit greater heterogeneity in behavioral presentation and outcomes relative to infants at low familial risk (LR), yet there is limited understanding of the diverse developmental profiles that characterize these infants. We applied a hierarchical agglomerative cluster analysis approach to parse developmental heterogeneity in 420 toddlers with heightened (HR) and low (LR) familial risk for ASD using measures of four dimensions of development: language, social, play, and restricted and repetitive behaviors (RRB). Results revealed a two-cluster solution. Comparisons of clusters revealed significantly lower language, social, and play performance, and higher levels of restricted and repetitive behaviors in Cluster 1 relative to Cluster 2. In Cluster 1, 25% of children were later diagnosed with ASD compared to 8% in Cluster 2. Comparisons within Cluster 1 between subgroups of toddlers having ASD+ versus ASD− 36-month outcomes revealed significantly lower functioning in the ASD+ subgroup across cognitive, motor, social, language, symbolic, and speech dimensions. Findings suggest profiles of early development associated with resiliency and vulnerability to later ASD diagnosis, with multidimensional developmental lags signaling vulnerability to ASD diagnosis.

Less than half of stool samples from people symptomatic with infectious intestinal disease (IID) will identify a causative organism. A secondary data analysis was undertaken to explore whether symptomology alone could be used to make inferences about causative organisms. Data were utilised from the Second Study of Infectious Intestinal Disease in the Community. A total of 844 cases were analysed. Few symptoms differentiated individual pathogens, but grouping pathogens together showed that viral IID was more likely when symptom onset was in winter (odds ratio (OR) 2.08, 95% confidence interval (CI) 1.16–3.75) or spring (OR 1.92, 95% CI 1.11–3.33), the patient was aged under 5 years (OR 3.63, 95% CI 2.24–6.03) and there was loss of appetite (OR 2.19, 95% CI 1.29–3.72). The odds of bacterial IID were higher with diarrhoea in the absence of vomiting (OR 3.54, 95% CI 2.37–5.32), diarrhoea which persisted for >3 days (OR 2.69, 95% CI 1.82–3.99), bloody diarrhoea (OR 4.17, 95% CI 1.63–11.83) and fever (OR 1.67, 95% CI 1.11–2.53). Symptom profiles could be of value to help guide clinicians and public health professionals in the management of IID, in the absence of microbiological confirmation.

Patients treated with palliative intent present a complex issue for radiotherapy departments in terms of their specific care needs, treatment times, and the productivity of orthovoltage resources. This study seeks to evaluate and quantify patient-related factors, treatment times, and to assess tools and data for future utilisation by radiotherapy departments. A modified Basic Treatment Equivalent (BTE) methodology was chosen, with stopwatch timings taken of treatments on orthovoltage units, over a 4-week period at two radiotherapy departments. Data collected included patient-related, treatment and equipment factors to assess their relative or specific effects on treatment times. Analysis considered the differences in data sets, significance and correlation. Forty-three fractions of treatment were recorded, across a range of treatment sites. The number of fields and delivery of first fractions/plan and treat episodes were found to result in significant differences in treatment time. The use of equipment, age and performance status were not found to be influential. Pain and skin viability symptoms had the greatest impact on treatment times–with these themselves being influenced by the impact of number of fields treated and first fractions. A full study should now be undertaken with a view to design a new equivalence model for the effective assessment of orthovoltage productivity.