Microstructured surfaces with pillar arrays are widely used to control the wetting morphology and spreading dynamics of droplets. In both simulations and experiments, it is shown that fabricating the surface with various microstructures is a very effective method for achieving the desired symmetry of the moving contact line. However, the method for characterizing miscellaneous pillar-arrayed microstructured surfaces is still insufficient. This paper presents the configurational entropy to characterize the microstructured surfaces with pillar arrays. By calculating the configurational entropy of pillar-arrayed microstructured surfaces, the relationship between the configurational entropy and the wetting morphology of droplets is obtained. For pillar-arrayed microstructured surfaces with the configurational entropy S > 0, the droplet wetting morphology may be much more complex than those with S = 0. The relationship is found to be consistent with the previous results. Furthermore, the wetting dynamics has been analysed. This study may be useful to understand the mechanism of droplet wetting on pillar-arrayed microstructured surfaces and provide insights for the design and manufacture of microstructured surfaces.

Metathesis poses challenges for a typologically constrained theory of phonology: despite being simple to describe, its distribution is highly restricted, making it difficult to create analyses that make predictions while not overgenerating. Here, I investigate metathesis in Uab Meto (Austronesian; Indonesia), an understudied language with CV metathesis that is synchronic and productive. Drawing on original fieldwork, I argue that metathesis is not transposition, but instead a serial delete-and-spread mechanism (cf. Takahashi 2018, 2019). To support this, I present a deep case study into the language’s phonology, showing that metathesis arises from spreading, deletion and epenthesis patterns. I propose that synchronic metathesis systems like Uab Meto’s can only emerge from the successive application of these mechanisms, and hypothesise that true transposition, if it exists, only arises through morpheme-specific operations. This study thus presents a new look onto the typology of synchronic metathesis, and offers an explanatory account of its typological rarity.

Although the African continent is, for the moment, less impacted than the rest of the world, it still faces the risk of a spread of COVID-19. In this study, we have conducted a systematic review of the information available in the literature in order to provide an overview of the epidemiological and clinical features of COVID-19 pandemic in West Africa and of the impact of risk factors such as comorbidities, climatic conditions and demography on the pandemic. Burkina Faso is used as a case study to better describe the situation in West Africa. The epidemiological situation of COVID-19 in West Africa is marked by a continuous increase in the numbers of confirmed cases. This geographic area had on 29 July 2020, 131 049 confirmed cases by polymerase chain reaction, 88 305 recoveries and 2102 deaths. Several factors may influence the SARS-CoV-2 circulation in Africa: (i) comorbidities: diabetes mellitus and high blood pressure could lead to an increase in the number of severe cases of SARS-CoV-2; (ii) climatic factors: the high temperatures could be a factor contributing to slow the spread of the virus and (iii) demography: the West Africa population is very young and this could be a factor limiting the occurrence of severe forms of SARS-CoV-2 infection. Although the spread of the SARS-CoV-2 epidemic in West Africa is relatively slow compared to European countries, vigilance must remain. Difficulties in access to diagnostic tests, lack of hospital equipment, but also the large number of people working in the informal sector (such as trading, businesses, transport and restoration) makes it difficult to apply preventive measures, namely physical distancing and containment.

Processes of unbounded spreading are often claimed to be myopic (e.g. Wilson 2003, McCarthy 2009): the ability of some feature [F] to spread from some segment z to some segment y does not depend on its ability to spread from y to x. Recent work (e.g. Walker 2010, 2014; Jardine 2016) has however cast doubt on the universality of this claim. This paper contributes to the discussion on (non-)myopia on by suggesting that a kind of non-myopic process, trigger deletion, is attested in Gurindji (Pama–Nyungan, McConvell 1988): when the spreading domain contains a certain kind of blocking segment, the spreading trigger deletes. In order to capture this pattern, as well as the extant typology of non-myopic processes, I argue that any successful analysis of unbounded spreading must allow surface candidates to be globally evaluated.

Leishmaniasis develops after parasites establish themselves as amastigotes inside mammalian cells and start replicating. As relatively few parasites survive the innate immune defence, intracellular amastigotes spreading towards uninfected cells is instrumental to disease progression. Nevertheless the mechanism of Leishmania dissemination remains unclear, mostly due to the lack of a reliable model of infection spreading. Here, an in vitro model representing the dissemination of Leishmania amastigotes between human macrophages has been developed. Differentiated THP-1 macrophages were infected with GFP expressing Leishmania aethiopica and Leishmania mexicana. The percentage of infected cells was enriched via camptothecin treatment to achieve 64·1 ± 3% (L. aethiopica) and 92 ± 1·2% (L. mexicana) at 72 h, compared to 35 ± 4·2% (L. aethiopica) and 36·2 ± 2·4% (L. mexicana) in untreated population. Infected cells were co-cultured with a newly differentiated population of THP-1 macrophages. Spreading was detected after 12 h of co-culture. Live cell imaging showed inter-cellular extrusion of L. aethiopica and L. mexicana to recipient cells took place independently of host cell lysis. Establishment of secondary infection from Leishmania infected cells provided an insight into the cellular phenomena of parasite movement between human macrophages. Moreover, it supports further investigation into the molecular mechanisms of parasites spreading, which forms the basis of disease development.

Between October and November 2010, several individuals of Fistularia commersonii, a lessepsian species, were fished by trammel nets in less than two weeks along the French coast in the north-western Mediterranean. These catches represent the most important records of the species in the western basin of the Mediterranean to date, specifically in areas where the species has rarely been observed before. This paper synthesizes the records of F. commersonii along the French coast starting from the first record in November 2007 until the most recent reports, and discusses the present status of the species in the north-western Mediterranean Sea.

A single male specimen of Ogyrides mjoebergi was captured on 28 September 2005, in the Gulf of Antalya. With this new locality, this species seems to have started to spread to a wider area by the Levantine Sea coasts in Turkey.

The results of studies on the schistosomulicidal activity of activated peritoneal and alveolar macrophages (pMø and aMø) from rats immunized with highly irradiated (50 krad.) Schistosoma japonicum cercariae are reported. The authors have examined the activation of these macrophages in terms of spreading, adhesion and ingestion of sheep erythrocytes and pinocytosis of horse-radish peroxidase. Using three criteria, peritoneal macrophages and alveolar macrophages from immunized rats and from rats intraperitoneally injected with BCG were significantly more active than those from normal rats or rats stimulated with 10% proteose-peptone or 1% sodium thioglycolate. A significantly higher percentage of adhesion and ingestion was obtained with the sheep erythrocytes that were co-opsonized by heat-inactivated rat anti-sheep erythrocyte serum and fresh normal rat serum. Schistosomulicidal effects were observed with macrophages from irradiated cercariae-immunized rats in two activation systems: in vitro activation in the presence of macrophage-activating factor (MAF), and in vivo activation by the intraperitoneal challenge with sonicated cercarial antigens.