This article focuses on debates about the relationship between religion, science and national identity that unfolded in late nineteenth- and early twentieth-century Bengal. Combining perspectives from religious studies and global history, it offers a specific approach to theoretical and methodological issues revolving around entanglement, agency and modernity. This will be operationalized, first, through an exploration of personal networks surrounding the Bengali Tantric pandit Shivachandra Bhattacharya Vidyarnava; his Bengali disciple, philosopher and nationalist educator, Pramathanath Mukhopadhyay and Shivachandra’s British disciple, the judge John Woodroffe. Second, an investigation of the connections between self-referentially ‘orthodox’ societies, so-called reformers, and the Theosophical Society will further illustrate the global exchanges that conditioned and shaped contemporary debates about religion, science and politics. This will complicate and shed new light on the contested relationship between modernity and tradition, or reformism and orthodoxy, opening new perspectives for further dialogue between religious studies and global history.