What drives changes in the thematic focus of state-linked manipulated media? We study this question in relation to a long-running Iranian state-linked manipulated media campaign that was uncovered by Twitter in 2021. Using a variety of machine learning methods, we uncover and analyze how this manipulation campaign’s topical themes changed in relation to rising Covid-19 cases in Iran. By using the topics of the tweets in a novel way, we find that increases in domestic Covid-19 cases engendered a shift in Iran’s manipulated media focus away from Covid-19 themes and toward international finance- and investment-focused themes. These findings underscore (i) the potential for state-linked manipulated media campaigns to be used for diversionary purposes and (ii) the promise of machine learning methods for detecting such behaviors.