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Vertebral compression fractures are characterized by a break in the vertebrae comprising the spinal column, most likely on the anterior side and most commonly occurring when the osseous matrix has been weakened. The high morbidity and mortality associated with VCFs have given rise to an estimated annual medical cost of $13.8 billion in the United States alone. Prevention includes screening at-risk individuals’ bone marrow density and augmenting individuals with decreased bone density with bisphosphonates or RANK ligand inhibitors. The management of VCFs has been heavily debated with arguments for both conservative management and invasive augmentation through vertebroplasty and kyphoplasty. Invasive management should be considered in patients with uncontrolled pain, significant vertebral misalignment, and height deformities.
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