Multilayer graphs consist of several graphs, called layers, where the vertex set of all layers is the same but each layer has an individual edge set. They are motivated by real-world problems where entities (vertices) are associated via multiple types of relationships (edges in different layers). We chart the border of computational (in)tractability for the class of subgraph detection problems on multilayer graphs, including fundamental problems such as maximum-cardinality matching, finding certain clique relaxations, or path problems. Mostly encountering hardness results, sometimes even for two or three layers, we can also spot some islands of computational tractability.