Antarctic research remains an enterprise in which people with certain backgrounds and identities have distinct career advantages over others. In this paper, we focus on barriers to women's participation and success in Antarctic research. Drawing on feminist social science literature on gender inequality in science, we identify two foundational, interrelated factors that have hampered progress across global Antarctic research. We propose that these barriers can be effectively addressed through intersectional approaches to change. We synthesize a broad range of multidisciplinary research on intersectionality in scientific workplaces and apply this literature to the unique institutional, historical and geographical contexts of Antarctic research. We argue that an intersectional lens improves understanding of persistent gender inequalities in Antarctic research, and we offer examples of how intersectionality can be practically applied within Antarctic institutions and communities. By embracing intersectional approaches to change, the Antarctic research community has the opportunity to lead in the advancement of equitable global scientific cultures and to fully realize Antarctica's potential as a place for peaceful, scientific collaboration by and for all humanity - not just a privileged few.