To obtain accurate navigation results with respect to Earth simultaneously with those with respect to the target for an interplanetary probe to approach the target planet, this paper proposes a Radio/Optical integrated navigation method based on ephemeris correction, which deeply affects the fusion accuracy. In this paper, the model of the ephemeris error is established, and taking the analytical solution of the ephemeris uncertainty as measurement, the target ephemeris error and its covariance are estimated by Kalman filter and fed back to modify the force models. By correcting the target ephemeris and using information fusion, the Radio/Optical integrated navigation prevents the ephemeris uncertainty polluting the fusion accuracy, and efficiently combines the radio and optical navigation results. The results show the influence of the ephemeris error can be removed, and the Radio/Optical integrated navigation is capable of providing accurate navigation results with respect to Earth and the target. The results demonstrate the proposed method yields an accuracy superior to the conventional method, which proves its effectiveness.