Field research was conducted in Nebraska to evaluate the efficacy of herbicides for the control of summer annual weeds in sorghum [Sorghum bicolor (L.) Moench.]. During 1976 to 1979, no-till plots treated with a mixture of paraquat (1,1′-dimethyl-4,4′-bipyridinium ion), atrazine [6-chloro-N-ethyl-N′-(1-methylethyl)-1,3,5-triazine-2,4-diamine], and terbutryn [N-(1,1-dimethylethyl)-N′-ethyl-6-(methylthio)-1,3,5-triazine-2,4-diamine] yielded 33% more sorghum grain than plots receiving the same herbicides when a seedbed was prepared by disking. During 1981 to 1983, season-long weed control was obtained with acetochlor [2-chloro-N-(ethoxymethyl)-N-(2-ethyl-6-methylphenyl) acetamide], alachlor [2-chloro-N-(2,6-diethylphenyl)-N-(methoxymethyl)acetamide], cyanazine {2-[[4-chloro-6-(ethylamino)-1,3,5-triazin-2-yl] amino]-2-methylpropanenitrile}, metolachlor [2-chloro-N-(2-ethyl-6-methylphenyl)-N-(2-methoxy-1-methylethyl)acetamide], or terbutryn added to paraquat plus atrazine and metolachlor plus cyanazine plus paraquat applied 10 days prior to planting. The use of seed safeners did not increase sorghum yield.