This chapter provides a research agenda for pediatric climate distress. It is structured into five domains. First, it reviews the importance of delineating among existing definitions of climate distress, including distinguishing between normal and pathological stress responses and integrating concepts from existing anxiety literature. Second, it discusses the importance of researching the epidemiology of climate distress, including developing and validating measurement tools, identifying young people most vulnerable and resilient, and considering the effects of parental mental health and social determinants of health on youths’ psychological responses. Third, it highlights the need to explore the psychological meaning and sequelae of climate change, including moral disengagement, dialectics of climate distress, and moral outrage. Fourth, it points to conventional and novel interventions to address climate distress that require further investigation. Fifth, it reviews the need to assess how climate change may impact young peoples’ psychological distress on a biological level. It concludes with recommendations for how to foster interdisciplinary collaborations and increase funding for this research.