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Common neuroanatomical regions are associated with both states of anorexia nervosa (AN) and autistic characteristics, but restoration of body mass index (BMI) has been associated with decreased presentation of autistic characteristics in some individuals with AN. This study aims to examine neuroanatomical correlates associated with autistic characteristics in those with acute anorexia nervosa (ac-AN) and those previously diagnosed with AN but whose weight has been restored (WR). In total, 183 individuals (healthy controls [HCs] = 67; n[ac-AN] = 68; n[WR] = 48) from the Brain imaging of Emotion And Cognition of adolescents with Anorexia Nervosa (BEACON) study were included, with autistic characteristics determined in both ac-AN and WR individuals (n = 116). To further examine BMI, ac-AN and WR group associations were compared. Random forest regression (RFR) models examined whether autistic characteristics and morphology of the anterior cingulate cortex (ACC), middle frontal gyrus (MFG), and orbitofrontal cortex (OFC) were able to predict future levels of social anhedonia and alexithymia. Group-wise differences were identified within the volume and surface area of the MFG and OFC, which were unrelated to BMI. Autistic characteristics were inversely associated with MFG and ACC volume, with differences in associations between ac-AN and WR groups seen in the surface area of the MFG. RFR models identified moderate-to-weak performance and found that autistic characteristics were not important predictive features in a priori and exploratory models. Findings suggest that the presence of autistic characteristics in those with ac-AN are associated with the volume of the MFG and are unrelated to BMI restoration.
In this chapter we will examine the substantial overlap, similarities, and also connections between people with Hoarding Disorder, Obsessive Compulsive Personality, Attention Deficit Hyperactivity Disorder, and Autism. The importance of ADHD in many people with hoarding will be examined along with a discussion about how the increasing recognition of a link between the two conditions has led to research into new ways of treating Hoarding Disorder. It is also recognised that autism interacts with hoarding as well as ADHD in a number of ways. Some people with autism are unable to tolerate any clutter at all whilst others hoard huge numbers of items due difficulty in decision-making. In addition, a substantial proportion of people with autism also have a diagnosis of OCD. As has already been discussed (Chapter 5), OCD may present with hoarding symptoms due to the nature of obsessive thoughts as well as Hoarding Disorder also.
Autistic people have high levels of mental ill-health and an increased risk of suicide across the lifespan. Yet autistic people report difficulties communicating with healthcare professionals and accessing a range of healthcare services. At the same time, mental healthcare workers in other countries are reporting links between confidence when working with autistic patients and the degree of autism knowledge and training they can access.
Methods:
We sought to examine what factors helped or hindered Irish mental healthcare colleagues when working with autistic healthcare service users. An online survey using quantitative and qualitative metrics was circulated among psychiatrists who are members of the College of Psychiatrists of Ireland, both in training and at consultant level, from April 2021 to April 2022.
Results:
Knowledge of autism was high among psychiatrists (n = 140), but self-efficacy scores were variable, particularly in relation to care pathways. Self-efficacy was better among psychiatrists with caseloads of children and youth or individuals with co-occurring intellectual disabilities. Three key qualitative themes emerged relating to capacity and training of mental health professionals, ways to improve mental health services provision for autistic individuals and also the critical need for co-creation and neurodiversity affirmative care.
Conclusions:
The study highlighted critical systemic and professional challenges in providing mental health care to autistic people in Ireland. We provide recommendations for reducing these challenges and for enabling the development of inclusive, evidenced-based care to autistic individuals.
Self-injurious behaviors (SIB) are common in autistic people. SIB is mainly studied as a broad category, rather than by specific SIB types. We aimed to determine associations of distinct SIB types with common psychiatric, emotional, medical, and socio-demographic factors.
Methods
Participants included 323 autistic youth (~50% non−/minimally-speaking) with high-confidence autism diagnoses ages 4–21 years. Data were collected by the Autism Inpatient Collection during admission to a specialized psychiatric inpatient unit (www.sfari.org/resource/autism-inpatient-collection/). Caregivers completed questionnaires about their child, including SIB type and severity. The youth completed assessments with clinicians. Elastic net regressions identified associations between SIB types and factors.
Results
No single factor relates to all SIB types. SIB types have unique sets of associations. Consistent with previous work, more repetitive motor movements and lower adaptive skills are associated with most types of SIB; female sex is associated with hair/skin pulling and self-rubbing/scratching. More attention-deficit/hyperactivity disorder symptoms are associated with self-rubbing/scratching, skin picking, hair/skin pulling, and inserts finger/object. Inserts finger/object has the most medical condition associations. Self-hitting against surface/object has the most emotion dysregulation associations.
Conclusions
Specific SIB types have unique sets of associations. Future work can develop clinical likelihood scores for specific SIB types in inpatient settings, which can be tested with large community samples. Current approaches for SIB focus on the behavior functions, but there is an opportunity to further develop interventions by considering the specific SIB type in assessment and treatment. Identifying factors associated with specific SIB types may aid with screening, prevention, and treatment of these often-impairing behaviors.
Within the medical model, ‘impairment’ is required for a diagnosis of autism. However, the diagnostic manuals provide limited guidance as to how to interpret impairment, which can impact diagnostic rates and the provision of support. Impairment is discussed within the context of the medical model and current sociocultural landscape.
This chapter is divided into two sections. The first explains fundamental concepts in human genetics. Accounts of genetic findings involve concepts which can prove challenging. Terminology may be unfamiliar and some words have specialised meanings and may not always be used consistently. The first part aims to provide an overview of the key concepts. The subject matter is intrinsically dense and can be hard to take in, so the reader may wish to skim parts of this section and then refer back to it when necessary.
The second part shows how these concepts relate to a range of neuropsychiatric conditions. Before considering individual conditions, it is worth presenting some general principles which characterise the relationship between genetic variation and human disease, in particular in relationship to neuropsychiatric conditions. Modern research has impacted on how we think about this relationship, and so current accounts are somewhat different from what one finds in older sources.
Access to “big data” is a boon for researchers, fostering collaboration and resource-sharing to accelerate advancements across fields. Yet, disentangling complex datasets has been hindered by methodological limitations, calling for alternative, interdisciplinary approaches to parse manifold multi-directional pathways between clinical features, particularly for highly heterogeneous autism spectrum disorder (ASD). Despite a long history of male-bias in ASD prevalence, no consensus has been reached regarding mechanisms underlying sex-related discrepancies.
Methods
Applying a novel network-theory-based approach, we extracted data-driven, clinically-relevant insights from a well-characterized sample (http://sfari.org/simons-simplex-collection) of autistic males (N = 2175, Age = 8.9 ± 3.5 years) and females (N = 334, Age = 9.2 ± 3.7 years). Expert clinical review of exploratory factor analysis (EFA) results yielded factors of interest in sensory, social, and restricted and repetitive behavior domains. To offset inherent confounds of sample imbalance, we identified a comparison subgroup of males (N = 331) matched to females (by age, IQ). We applied data-driven causal discovery analysis (CDA) using Greedy Fast Causal Inference (GFCI) on three groups (all females, all males, matched males). Structural equation modeling (SEM) extracted measures of model-fit and effect sizes for causal relationships between sex, age-at-enrollment, and IQ on EFA-determined factors.
Results
We identified potential targets for intervention at nodes with mediating or indirect effects. For example, in the female and matched male groups, analyses suggest mitigating RRB domain behaviors may lead to downstream reductions in oppositional and self-injurious behaviors.
Conclusions
Our investigation unveiled sex-specific directional relationships that inform our understanding of differing needs and outcomes associated with biological sex in autism and may serve to further development of targeted interventions.
Childhood obsessive-compulsive disorder (OCD) stems from a bunch of restricted and repetitive behaviors, which are part of normal behavioral repertoire up to the age of 7. The persistence of compulsive-like behaviors after that age is often associated with unique comorbidity patterns, which are age-at-onset dependent and reflect different developmental stages. In particular, OCD synchronically co-occurs with a broad constellation of neurodevelopmental disorders, whereas diachronically it is related to an increased risk of major adult psychoses. Moreover, OCD is associated with trait-like sensory phenomena, suggesting a common disrupted sensorimotor grounding.
The present study is aimed at exploring the hypothesis that this specific temporal and comorbidity OCD profile may be due to a developmental heterochronic mechanism of delay in attenuation of ontogenetically early behavioral patterns. The developmental shift of highly evolutionarily conserved behavioral phenotypes might be regulated by epigenetic changes induced by different conditions of sensory unbalance. This evolutionary and developmental model allows capturing childhood OCD in light of the ultimate causes of ritual behavior throughout phylogeny, namely its “homeostatic” function over conditions of unpredictability. Moreover, it may have important clinical implications, as OCD symptoms could represent putative biomarkers of early divergent developmental trajectories, with a pathoplastic effect on course and outcome.
What next for autistics in the academy? In this chapter participants reflect on their career aspirations: the roles they aspire to and their expectations as to whether they will achieve their career goals. For those goals that seem out of reach, this chapter tries to answer the question of whether the barriers are intrinsic to being autistic or are systemic and structural.
This chapter explores the experience of receiving a diagnosis (or reaching a point of self-diagnosis) and how this diagnosis impacted the participants and their self-identity. It examines the extent to which they have developed (or are developing) a positive autistic identity, and the terminology they use to describe themselves and their diagnosis.
In this chapter participants reflect on the steps that senior academics and academic institutions could do to better support early career autistic academics. They also reflect candidly on the things that non-autistic colleagues and friends could do to make them feel more comfortable in both work and social settings.
This chapter describes the thirty-seven autistic academics who share their stories in this book. In a different world they would be introduced to the reader by name, with their unique personalities, interests, and gifts described. However, we live in a world where autism is still very much stigmatised and where disclosure comes with significant risks to career progression and social inclusion. Thus, many of the participants have asked to remain anonymous, and their combined stories are shared in a way that gives the reader a sense of their diversity while maintaining their anonymity.
The academic stereotype of the absent-minded professor who is valued for their in-depth subject knowledge and whose quirks and eccentricities are accepted by their peers is as faulty as the stereotype of the autistic as a white, adolescent, male maths wizard. Today’s academics are expected to teach, research, and engage in administrative and other activities. In this chapter thirty-two of the participants provide advice to autistic people considering a career in academia. They emphasise the importance of knowing what the role entails, both its strengths and its challenges; finding the right people to work with and to seek counsel from; knowing (and valuing) yourself; developing resilience; maintaining your well-being; and following your passion.
The field of autism research is moving from its troubled history of research on autistic people to research with autistic people. This recognition of the need for research both with and by autistic people means there is also a need to understand the extent to which autism conferences include or exclude the voices of autistic people. In this chapter, participants reflect on their experiences in attending conferences as recipients of knowledge, active participants in the conversation, and conveyors of information. Topics discussed include sensory issues, conference organisation, social interaction and networking, in-session interaction, in-session information, inclusion, and online conferences.
This chapter explores both the literal and figurative answers to the question of how the participants became autistic academics. From the literal standpoint, this includes pragmatic aspects such as the courses they studied and career pathways they followed, as well as the obstacles and successes they experienced in applying for positions in academia. From the figurative standpoint, it focuses on how and why they chose their particular disciplines and areas of research.
While the concept of reasonable adjustments is well-established in academia, and it is enshrined in university policy that we must support the provision of these adjustments for our students, autistic employees may not always feel empowered to ask for necessary adjustments to thrive in an academic workplace. In this chapter participants reflect on the process of requesting and receiving adjustments, including those that have been denied and those that they wish they could ask for.
This chapter explores the bi-directional challenges of autistics in the academy. Many of the challenges experienced by autistic people in academia are similar to those experienced in other aspects of our lives – dealing with sensory challenges, different processing styles, social interaction, and communication. Other challenges that are inherent to academia include the breadth of activity, the performance and competitive aspects of the role, and complicated institutional politics.
In academia, as in any profession, one of the toughest decisions facing an autistic person is whether and when to disclose their diagnosis. On the one hand, disclosure can bring awareness, understanding, and support. On the other, it can bring misunderstanding, stigma, and discrimination. In this chapter participants reflect on their decisions to disclose (or not to disclose) to employers, colleagues, staff, and students – and the impacts of these decisions. This chapter also addresses the issue of masking (hiding their autistic characteristics), including when and why participants feel the need to mask and the impact this has on them.
This chapter explores the bi-directional strengths of autistics in the academy: the strengths that autistic people bring to their role, and the strengths of the university environment as a workplace for academics. Key strengths of autistic people that are beneficial in academic roles include focused interests, attention to detail, pragmatism, and many other aspects that may not be evident in common stereotypes of autism. Strengths of the academic environment as an autistic workplace include the cerebral nature of the role, structured interactions, and the value placed on in-depth knowledge. Combined, these bi-directional strengths are expanded on in the context of the resulting capacity for autistic people in academia to learn, teach, work, help, and connect.
The journey to a career in academia commences with university studies. Autistic people continue to be under-represented in university enrolments, and even more under-represented in university graduations. In this chapter participants reflect on their university experience, including the transition to university. Topics discussed include interactions with peers, teaching staff, and administration; supports that were, or could have been, provided; and recommendations for improving the university experience for future autistic students.