This article presents a review of optical-fiber-based process-monitoring techniques that can be used to track the chemical reactions that take place during the processing of materials, with specific reference to thermosetting resins. The techniques covered include quantitative process-monitoring methods based on near and mid-infrared, Raman, UV–visible, evanescent wave, and fluorescence spectroscopy. The basis for refractive-index-based process monitoring using optical fibers is also presented. The techniques described here can be readily applied to other classes of materials and other areas of interest such as aging and degradation. Recent advances in noncontact process monitoring are also presented.