Efficient tools for predicting the drag of rough walls in turbulent flows would have a tremendous impact. However, accurate methods for drag prediction rely on experiments or numerical simulations which are costly and time consuming. Data-driven regression methods have the potential to provide a prediction that is accurate and fast. We assess the performance and limitations of linear regression, kernel methods and neural networks for drag prediction using a database of 1000 homogeneous rough surfaces. Model performance is evaluated using the roughness function obtained at a friction Reynolds number $Re_\tau$ of 500. With two trainable parameters, the kernel method can fully account for nonlinear relations between the roughness function $\Delta U^+$ and surface statistics (roughness height, effective slope, skewness, etc.). In contrast, linear regression cannot account for nonlinear correlations and displays large errors and high uncertainty. Multilayer perceptron and convolutional neural networks demonstrate performance on par with the kernel method but have orders of magnitude more trainable parameters. For the current database size, the networks’ capacity cannot be fully exploited, resulting in reduced generalizability and reliability. Our study provides insight into the appropriateness of different regression models for drag prediction. We also discuss the remaining steps before data-driven methods emerge as useful tools in applications.