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2 results

  • Are obstetric complications related to adult schizophrenia? A case-control study

  • Mario Amore, Francesco Pisani, Chiara Balista, Marco Sarchiapone, Robin McCreadie
  • Journal:
    Acta Neuropsychiatrica / Volume 19 / Issue 6 / December 2007
    Published online by Cambridge University Press:
    24 June 2014, pp. 338-343
  • Background:

    Early environmental events may be relevant to the etiology of schizophrenia. Among such events, interest has focused especially on obstetric complications (OCs).

    Objective:

    Aims of the study were to compare the incidence of OCs in patients, siblings and normal controls and to examine the relationship between OCs and later schizophrenia.

    Method:

    One hundred and thirteen patients with schizophrenia were recruited, as were 140 patients’ siblings and 113 controls without schizophrenia. The OCs history of patients, their sibs and controls was obtained through interviews with patients’ and controls’ mothers.

    Results:

    The results highlighted that more patients than sibs had at least one definite OC and a higher mean number of OCs; more patients had premature rupture of membranes, threatened abortion and a labor of more than 36 h.

    Conclusions:

    Our data provide some evidence for a link between OCs and later schizophrenia. Furthermore, this study highlights how OCs, which may cause fetal distress through a hypoxic-ischemic mechanism, could increase the risk of schizophrenia interacting with genetic susceptibility.

  • The Northwestern University Twin Study. V: Twin Deliveries at Prentice Women's Hospital and Maternity Center, 1978-83

  • L.G. Keith, R. Depp, M.W. Method, R. Wittman, J. Lopez-Zeno, J. Minoque, R. Nearhing, D.M. Keith
  • Journal:
    Acta geneticae medicae et gemellologiae: twin research / Volume 37 / Issue 1 / January 1988
    Published online by Cambridge University Press:
    01 August 2014, pp. 1-10
    Print publication:
    January 1988
    • Article
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  • Two hundred fifty-one twin deliveries between January 1, 1978 and June 30, 1983 at Prentice Women's Hospital and Maternity Center were reviewed. Cases were excluded if birth weight was less than 500 g, if gestational age was less than 26 weeks or if an antenatal fetal demise had occurred. Maternal demographic characteristics, delivery data and infant characteristics are described. The effect of providing care to a high-risk population of mothers in whom approximately 60% either deliver thair infants preterm or with a birth weight of less than 2,500 g is discussed in terms of costs of care.