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1 results

  • Tacrolimus enhances the recovery of normal laryngeal muscle fibre distribution after reinnervation

  • P Gorphe, N Guerout, M Birchall, G Terenghi, J-P Marie
  • Journal:
    The Journal of Laryngology & Otology / Volume 126 / Issue 11 / November 2012
    Published online by Cambridge University Press:
    04 September 2012, pp. 1155-1158
    Print publication:
    November 2012
  • Objectives:

    To assess the recovery of various muscle fibre types in the posterior cricoarytenoid muscle after laryngeal reinnervation in the rat, and to determine the influence of tacrolimus on this process.

    Methods:

    Four groups of rats underwent resection and anastomosis of the left vagus nerve, and were administered either tacrolimus at a low dose or an immunosuppressive dose, or cyclosporin A at a low dose or an immunosuppressive dose. A fifth group received surgery alone, and a sixth group received neither surgery nor drug treatment (healthy group). Muscles were removed for immunohistochemical analysis 45 days after surgery.

    Results:

    There was no difference in the proportion of types 1, 2a and 2b muscle fibres, comparing the immunosuppressive tacrolimus group and the healthy group, whereas there were fewer type 1 fibres in the group receiving surgery alone, compared with the healthy group (7 vs 12.1 per cent, respectively; p = 0.0303).

    Conclusion:

    Tacrolimus enhanced the recovery of normal laryngeal muscle fibres after reinnervation in the rat, indicating a possible role in laryngeal transplantation.