Field studies were conducted in Louisiana and Mississippi in 2009 and 2010 to evaluate coapplications of glyphosate, pyrithiobac, and residual herbicides on growth and yield of glyphosate-resistant cotton. Treatments were a factorial arrangement of glyphosate (0 and 860 g ae ha−1), pyrithiobac (0 and 470 g ai ha−1), and two residual herbicides (pendimethalin [1,120 g ai ha−1], S-metolachlor [1,070 g ai ha−1], and no residual herbicide). Cotton injury was greatest 3 d after treatment (DAT) and decreased at each evaluation interval until 28 DAT when pyrithiobac was coapplied with glyphosate. Cotton injury ranged from 4 to 17% through 14 DAT when pyrithiobac was applied alone (no residual herbicide) or with pendimethalin, but injury decreased to ≤ 3% after 14 DAT. Cotton injury 3 to 21 DAT following pyrithiobac plus S-metolachlor ranged from 4 to 31%, but S-metolachlor alone injured cotton 1 to 7%. When pyrithiobac was included, cotton injury following S-metolachlor was 3 to 15% greater than that following pendimethalin from 3 to 14 DAT. Pendimethalin did not reduce plant height at 21 or 42 DAT compared with treatments receiving no residual herbicide, but S-metolachlor reduced plant heights 5 and 4% at 21 and 42 DAT, respectively. Although cotton injury was severe in some cases and persisted until 21 DAT, the injury did not cause reductions in yield. This indicates the early-season cotton injury was transient, and cotton was able to recover from the injury with no observed differences in yield.