Hostname: page-component-78c5997874-ndw9j Total loading time: 0 Render date: 2024-11-12T20:29:23.872Z Has data issue: false hasContentIssue false

Association of antepartum vitamin D deficiency with postpartum depression: a clinical perspective

Published online by Cambridge University Press:  18 January 2019

Mercedes J Szpunar*
Affiliation:
Department of Psychiatry, University of California, San Diego, 200 Arbor Drive #0851, San Diego, CA92103, USA
*
*Corresponding author: Email [email protected]
Rights & Permissions [Opens in a new window]

Abstract

Objective

Postpartum depression affects up to 20 % of new mothers within the first 12 months of parturition. 25-Hydroxyvitamin D (25(OH)D) has known importance in bone health, but it may also play an important role in other functions, including reproduction and fertility, immune function and mental health. This clinical commentary reviews literature evaluating 25(OH)D deficiency during pregnancy and the incidence of postpartum depressive symptomatology.

Design

Narrative review, summary and recommendations.

Setting/Participants

A literature search revealed five relevant studies of antepartum women, three based in the USA, one in Turkey and one in Iran.

Results

Three of the five studies measured serum 25(OH)D concentrations during the first or second trimester and discovered an association with 25(OH)D deficiency and depressive symptoms postpartum. One study determined an almost significant (P=0·058) inverse relationship with first-trimester 25(OH)D concentration and depressive symptoms postpartum, and the last study, which was a secondary analysis, did not find an association.

Conclusions

The Endocrine Society recommends routine vitamin D supplementation during pregnancy and lactation due to increased metabolic demand in the mother, but a recent Cochrane review recommended against screening. Vitamin D should be the target of more studies during pregnancy and the postpartum period since it appears to have an important role for both medical and mental health. Vitamin D supplementation is a relatively safe and cost-effective intervention during pregnancy, and it may prove to be important in the prevention of postpartum depression.

Type
Commentary
Copyright
© The Author 2019

Postpartum depression (PPD) affects up to 20 % of women within the first 12 months of parturition(Reference Gaynes, Gavin and Meltzer-Brody1). Similar to major depressive disorder (MDD), symptoms may include sadness, anhedonia, feeling overwhelmed, mood lability, irritability, sleep and appetite disturbance, and guilt(Reference Gaynes, Gavin and Meltzer-Brody1Reference Steward and Vigod3). Peripartum (antepartum and postpartum) depression can have negative consequences for both the mother and developing child, and hence diagnosis and appropriate treatment should be of paramount public health priority(Reference Brockington, Butterworth and Glangeaud-Freudenthal4). Nutritional measures have been utilized as both treatment interventions and as possible markers of depression in the peripartum period, and pregnant women are susceptible to the effects of nutrient deficiencies due to increased nutritional demands from the developing fetus(Reference Bodnar and Wisner5, Reference Ellsworth-Bowers and Corwin6). Standard prenatal vitamins may be inadequate for the requirements of specific nutrients, such as vitamin D(Reference Bodnar, Simhan and Powers7).

The term ‘vitamin D’ encompasses a family of secosteroid hormones produced after exposure to sunlight (i.e. via UVB radiation) in fungi (ergocalciferol; vitamin D2) and in animal tissue (cholecalciferol; vitamin D3). Cholecalciferol is produced endogenously in human skin after exposure to UVB radiation, especially during the summer. Hence, sunlight is critical to vitamin D status given the limited availability of ergocalciferol and cholecalciferol from dietary sources(Reference Shin, Choi and Longtin8). Ergocalciferol and cholecalciferol are metabolized in the liver to form 25-hydroxyvitamin D (25(OH)D), the predominant form of vitamin D in the blood(Reference Miller and Peters9). In addition to its importance in bone health(Reference Miller and Peters9), 25(OH)D may function in reproduction(Reference Grundmann and von Versen-Höynck10, Reference Mumford, Garbose and Kim11) and in the promotion of immune health(Reference Shin, Choi and Longtin8, Reference Brannon12). Exposure to sunlight and UVB radiation are important considerations when evaluating for 25(OH)D. For example, lower concentrations are expected in the winter months, which are characterized by shorter days and therefore decreased exposure to sunlight(Reference Holick, Binkley and Bischoff-Ferrari13). Another important consideration is skin pigmentation because melanin differentially absorbs UVB. Hence, African Americans are at higher risk for vitamin D deficiency compared with Caucasian Americans(Reference Bodnar, Simhan and Powers7, Reference Harris14). Recent research has implicated low 25(OH)D as a possible cause of depressive symptoms(Reference Hoang, Defina and Willis15), which is more pronounced in women than men(Reference Gur, Genc and Eskicioglu16Reference Polak, Houghton and Reeder19). This finding continues to be investigated, and a causal link remains to be elucidated.

As stated by the Institute of Medicine, 25(OH)D sufficiency is defined as ≥ 20 ng/ml (≥50 nmol/l) and deficiency is defined as <12 ng/ml (<30 nmol/l); the range between, 12–20 ng/ml (30–50 nmol/l), is defined as potential risk for inadequacy. Greater than 30 ng/ml (>75 nmol/l) is not associated with improved benefit(20). Conversely, the Endocrine Society defines 25(OH)D deficiency as <20 ng/ml (<50 nmol/l), insufficiency as 21–29 ng/ml and sufficiency as 30–100 ng/ml(Reference Holick, Binkley and Bischoff-Ferrari13). Although these ranges differ slightly, both organizations agree that <20 ng/ml is potentially inadequate or worse, and the more stringent criteria by the Endocrine Society recommend a target minimum concentration of 30 ng/ml(Reference Holick, Binkley and Bischoff-Ferrari13).

Several studies have demonstrated correlations of low 25(OH)D concentration in early pregnancy with increased depressive symptomatology later in pregnancy(Reference Brandenbarg, Vrijkotte and Goedhart21Reference Cunha Figueiredo, Trujillo and Freitas-Vilela23). The present commentary encompasses the findings of currently published literature regarding 25(OH)D deficiency during pregnancy and depressive symptoms in the postpartum period.

Methods

A literature search was performed using PubMed, PsycINFO and Web of Science. Keywords included combinations of ‘pregnancy’ or ‘postpartum’ with ‘depression’ and ‘vitamin D’. Studies were considered if published in peer-reviewed, English-language journals, if a serum 25(OH)D concentration was obtained during pregnancy (prior to the day of parturition), and a validated assessment for depressive symptoms was utilized during the postpartum period. Articles were excluded if written as a review article or case report, not focused on human research, or if oral administration of vitamin D was not verified by a corresponding serum concentration. While over 150 articles were initially identified, only five were relevant after excluding duplicates and applying inclusion and exclusion criteria. Data extraction from each study included the author, year of publication, sample size, study description, time of serum collection, scale of depressive symptom assessment and a brief description of reported outcomes (Table 1). The studies are organized by chronology, then alphabetically.

Table 1 25-Hydroxyvitamin D deficiency and postpartum depressive symptoms

25(OH)D, 25-hydroxyvitamin D; RCT, randomized controlled trial; PPD, postpartum depression; EPDS, Edinburgh Postnatal Depression Scale; CLIA, chemiluminescence immunoassay; CES-D, Center for Epidemiological Studies Depression Scale; BDI, Beck Depression Inventory; MINI, Mini International Neuropsychiatric Interview; PP, postpartum.

Results

As delineated in Table 1, four of the five studies utilized the Edinburgh Postnatal Depression Scale (EPDS)(Reference Cox, Holden and Sagovsky24) for evaluation of depressive symptoms, and the study by Williams et al. used both the Beck Depression Inventory (BDI)(Reference Beck, Ward and Mendelson25) and the clinician-administered Mini International Neuropsychiatric Interview (MINI)(Reference Williams, Romero and Clinton26). All studies used the Endocrine Society’s definition of 25(OH)D deficiency, <20 ng/ml(Reference Holick, Binkley and Bischoff-Ferrari13).

Gur and colleagues recruited 179 medically healthy pregnant women from a university hospital setting in Turkey(Reference Gur, Gokduman and Turan27). They measured serum 25(OH)D between 24 and 28 weeks’ gestation and at 6 months postpartum. 25(OH)D was defined as severely deficient if <10 ng/ml and mildly deficient if <20 ng/ml; the prevalence in the antepartum women was 11·0 and 40·3 %, respectively. These women were assessed by EPDS (Turkish version) at 1 week, 6 weeks and 6 months postpartum. Depression (defined as EPDS≥12) ranged from 21·6 to 23·7 %. Lower maternal 25(OH)D at 24–28 weeks’ gestation was associated with higher levels of depressive symptoms at 1 week, 6 weeks and 6 months postpartum. The study did not control for other risk factors, such as personal or family history of MDD. Additionally, it excluded women ‘prone’ to PPD for reasons including unmarried status, unplanned pregnancy, low socio-economic status, medical or psychiatric illness at time of enrolment, and complications at time of delivery(Reference Gur, Gokduman and Turan27).

Vaziri et al. performed an interventional randomized controlled trial in Iran(Reference Vaziri, Nasiri and Tavana28). The participants provided serum for 25(OH)D determination at 26–28 weeks’ gestation (baseline) and within the first 24 h postpartum. EPDS was obtained at four time points: 26–28 and 38–40 weeks’ gestation; and at 4 and 8 weeks postpartum. The women were randomized to receive supplementation of 50µg (2000IU) cholecalciferol or placebo, and baseline EPDS was not different between the two groups. At baseline, 72·8 % of the women were 25(OH)D deficient (<20 ng/ml); additionally, 9·8 % of the women were categorized as insufficient (21–29 ng/ml). In the treatment arm, the average 25(OH)D serum concentration increased by about 4·6 ng/ml over approximately 12 weeks of treatment, whereas in the placebo arm concentration remained constant (near 12 ng/ml). EPDS scores were significantly lower at all three subsequent time points in the treatment arm. Limitations of the study include: exclusion of women with EPDS>13 at first assessment (i.e. women with elevated depressive symptoms); and the cholecalciferol intervention required self-administration, which does not ensure daily supplementation(Reference Vaziri, Nasiri and Tavana28).

Lamb et al. recruited 126 pregnant women from a large urban medical centre from their prenatal appointments(Reference Lamb, Lutenbacher and Wallston29). The EPDS and serum for 25(OH)D determination were gathered at 14 and 32 weeks’ gestation. In the postpartum, serum was collected at 6 weeks and EPDS at 10 weeks. The authors concluded that the EPDS was consistent over time in their sample and elevated depressive symptoms (defined as EPDS score ≥10) was inversely correlated with 25(OH)D concentrations at all three time points. At 14 weeks’ gestation, 25(OH)D deficiency (<20ng/ml) was determined in 21·6 % of their study population; this deficiency reduced to 12·5 % by the postpartum period. An explanation for this reduction may have been the initiation of prenatal vitamins containing vitamin D. Interestingly, the authors also determined lower 25(OH)D concentrations in two populations: (i) women requiring a caesarean delivery; and (ii) women with postpartum haemorrhage. Limitations of the study include an attrition rate of 30 % by the last time point and missing 25(OH)D samples from some of the study participants(Reference Lamb, Lutenbacher and Wallston29).

Accortt and colleagues obtained serum from ninety-one African-American women at an average at 9·7 weeks’ gestation(Reference Accortt, Schetter and Peters30). They measured serum 25(OH)D as well as inflammatory cytokines. Using the cut-off of 20 ng/ml, 85 % of the women were discovered to be 25(OH)D deficient. When assessed by EPDS at 4–6 weeks postpartum, 12 % of the women had an elevated EPDS, and the authors noted that the EPDS scores were higher in overweight or obese women. Higher concentration of 25(OH)D was protective against postpartum depressive symptoms with marginal significance (P=0·058). Limitations of the study include that 50 % of the original study population (n 85) was lost to follow-up (i.e. did not complete EPDS in the postpartum period). As the study was a secondary analysis, the authors were unable to obtain a repeat measure(Reference Accortt, Schetter and Peters30).

Williams et al. performed a secondary analysis of a randomized controlled trial designed to assess for n-3 fatty acid supplementation during pregnancy as protective against postpartum depressive symptoms(Reference Williams, Romero and Clinton26). In the original study, 126 women at high risk for PPD (EPDS score 9–19, or a past history of MDD) were randomized to receive supplementation with fish oil or placebo; 105 women completed data assessments(Reference Mozurkewich, Clinton and Chilimigras31). Serum for 25(OH)D determination was obtained at 12–20 and 34–36 weeks’ gestation; 16 and 12 % of the women were deficient, respectively. The BDI was utilized to evaluate depressive symptoms, as well as the MINI for diagnostic evaluation for MDD, at four time points: 12–20, 26–28 and 34–36 weeks’ gestation; and at 6–8 weeks postpartum. 25(OH)D deficiency at 12–20 weeks’ gestation was associated with higher depressive symptoms at 34–46 weeks’ gestation. More specifically, for every 1-unit increase in 25(OH)D since 12–20 weeks’ gestation, the BDI score decreased by 0·14 units. However, no association was observed between 25(OH)D deficiency and postpartum depressive symptoms. Limitations of the study include that it was a secondary data analysis of an interventional study that was designed to reduce depressive symptoms by treatment with n-3 fatty acids, and hence the original study purpose may have confounded these results(Reference Williams, Romero and Clinton26).

Discussion

Epidemiological evidence regarding the causation of depressive symptoms by 25(OH)D deficiency is limited, but some theorize that vitamin D may play an important role in mood(Reference Hoang, Defina and Willis15). This theory may prove to be more critical in women than men(Reference Gur, Genc and Eskicioglu16Reference Polak, Houghton and Reeder19). Ellsworth-Bowers and Corwin postulated that vitamin D impacts both the immune system and the hypothalamic–pituitary–adrenal axis to assert a regulatory role in the development in depression(Reference Ellsworth-Bowers and Corwin6). Early detection and treatment of PPD should be of high public health priority to prevent negative outcomes for both mothers and children(Reference Brockington, Butterworth and Glangeaud-Freudenthal4). The present commentary is unique in its focus on antepartum 25(OH)D assessment in concert with postpartum depressive symptomatology.

In an interventional randomized controlled trial with cholecalciferol supplementation, Vaziri et al. demonstrated improvement in both 25(OH)D serum concentration and EPDS scores by the end of pregnancy and at 2 months postpartum in mothers with 25(OH)D deficiency during the second trimester of pregnancy(Reference Vaziri, Nasiri and Tavana28). Similarly, Gur and colleagues measured 25(OH)D serum levels in women during their second trimester of pregnancy and determined increased depressive symptoms up to 6 months postpartum in 25(OH)D-deficient women(Reference Gur, Gokduman and Turan27). Most recently, Lamb et al. determined 25(OH)D deficiency during the first and third trimesters to be associated with increased depressive symptoms at 10 weeks postpartum(Reference Lamb, Lutenbacher and Wallston29). The two remaining studies reviewed here were secondary analyses and therefore were primarily designed to evaluate other hypotheses. Thus, their findings are interpreted with reservation as certain confounders were unavoidable.

Multiple studies have demonstrated that 25(OH)D deficiency during the first trimester of pregnancy is predictive of elevated depressive symptoms during the second and/or third trimesters(Reference Brandenbarg, Vrijkotte and Goedhart21Reference Cunha Figueiredo, Trujillo and Freitas-Vilela23). In three of the studies reviewed here, the prevalence of 25(OH)D deficiency was ≥40 %(Reference Gur, Gokduman and Turan27, Reference Vaziri, Nasiri and Tavana28, Reference Accortt, Schetter and Peters30). Clinicians may be surprised to learn of the high prevalence of 25(OH)D deficiency during pregnancy, which has been demonstrated in pregnant women living in other locations with high sun exposure (Brazil and Australia)(Reference Cunha Figueiredo, Trujillo and Freitas-Vilela23, Reference Robinson, Whitehouse and Newnham32). Curiously, a recent prospective cohort study discovered that 25(OH)D>30 ng/ml was associated with increased likelihood of conception and live birth in a cohort of women with a history of multiple pregnancy losses(Reference Hoang, Defina and Willis15). One plausible explanation is that requirements of 25(OH)D during pregnancy are even higher due to the demands of the developing fetus, and the threshold of 30 ng/ml may need to be redefined for this special population.

The present commentary has limitations, including the inability to directly compare studies due to methodological differences. The EPDS, utilized in most of these studies, was initially developed as an adjunct to diagnostic evaluation. While it provides a numerical score for comparison of symptoms, it does not assess for duration or intensity of depression nor clinically diagnose MDD(Reference Cox33). The studies have populations that are inherently different, such as Turkish, Iranian and African American; hence, the findings are not generalizable. Importantly, UVB radiation from sunlight plays a critical role in 25(OH)D production(Reference Shin, Choi and Longtin8), and one would expect different amounts of sun exposure based on the locations where the studies occurred.

A recent Cochrane review did not recommend routine screening of 25(OH)D in pregnant women, expressing concern for possible adverse effects of over-supplementation(Reference De-Regil, Palacios and Lombardo34). In contrast, the Endocrine Society recommends routine supplementation with cholecalciferol during pregnancy and lactation due to increased metabolic demand and as preventive against pre-eclampsia and required caesarean delivery(Reference Holick, Binkley and Bischoff-Ferrari13). Furthermore, a recent randomized field trial found a reduction in pregnancy complications (pre-eclampsia, gestational diabetes and preterm delivery) in women supplemented with cholecalciferol(Reference Rostami, Tehrani and Simbar35).

Cholecalciferol supplementation is a safe and cost-effective intervention during pregnancy(Reference Hollis, Johnson and Hulsey36). The present author and others conclude that vitamin D should be the target of more extensive research during pregnancy and the postpartum period, as it appears to be important for both the medical and mental health of the mother and developing child(Reference Bodnar and Wisner5, Reference Ellsworth-Bowers and Corwin6, Reference Grundmann and von Versen-Höynck10, Reference Gur, Genc and Eskicioglu16). All pregnant women should be screened for 25(OH)D and recommended cholecalciferol supplementation if deficient. For every 2·5 µg (100 IU) of oral supplementation, 25(OH)D serum concentration increases by approximately 1 ng/ml(Reference Hollis, Johnson and Hulsey36), which can be used as a guide for patient dosing.

Acknowledgements

Acknowledgements: The author would like to thank Michael McCarthy, MD, PhD for his guidance in the preparation of this manuscript. Financial support: The composure of this manuscript was funded by the National Institutes of Health (grant number R25 MH101072). The National Institutes of Health had no role in the design, analysis or writing of this article. Conflict of interest: There is no conflict of interest to declare. Authorship: M.J.S. was the sole author of this manuscript. Ethics of human subject participation: Not applicable.

References

1.Gaynes, BN, Gavin, N, Meltzer-Brody, Set al. (2005) Perinatal depression: prevalence, screening accuracy, and screening outcomes. Evid Rep Technol Assess (Summ) issue 119, 18.Google ScholarPubMed
2.O’Hara, MW (2009) Postpartum depression: what we know. J Clin Psychol 65, 12581269.CrossRefGoogle ScholarPubMed
3.Steward, DE & Vigod, S (2016) Postpartum depression. N Engl J Med 375, 21772186.CrossRefGoogle Scholar
4.Brockington, I, Butterworth, R & Glangeaud-Freudenthal, N (2017) An international position paper on mother–infant (perinatal) mental health, with guidelines for clinical practice. Arch Womens Ment Health 20, 113120.CrossRefGoogle ScholarPubMed
5.Bodnar, LM & Wisner, KL (2005) Nutrition and depression: implications for improving mental health among childbearing-aged women. Biol Psychiatry 58, 679685.CrossRefGoogle ScholarPubMed
6.Ellsworth-Bowers, ER & Corwin, EJ (2012) Nutrition and the psychoneuroimmunology of postpartum depression. Nat Res Rev 25, 180192.CrossRefGoogle ScholarPubMed
7.Bodnar, LM, Simhan, HN, Powers, RWet al. (2007) High prevalence of vitamin D insufficiency in black and white pregnant women residing in the northern United States and their neonates. J Nutr 137, 447452.CrossRefGoogle ScholarPubMed
8.Shin, JS, Choi, MY, Longtin, MSet al. (2010) Vitamin D effects on pregnancy and the placenta. Placenta 31, 10271034.CrossRefGoogle ScholarPubMed
9.Miller, RK & Peters, P (2014) Vitamins, minerals, and trace elements. In Drugs During Pregnancy and Lactation, pp. 493510 [C Schaefer, PWJ Peters and RK Miller, editors]. Amsterdam: Academic Press.Google Scholar
10.Grundmann, M & von Versen-Höynck, F (2011) Vitamin D – roles in women’s reproductive health? Reprod Biol Endocrinol 9, 146.CrossRefGoogle ScholarPubMed
11.Mumford, SL, Garbose, RA, Kim, Ket al. (2018) Association of preconception serum 25-hydroxyvitamin D concentrations with livebirth and pregnancy loss: a prospective cohort study. Lancet Diabetes Endocrinol 6, 725732.CrossRefGoogle ScholarPubMed
12.Brannon, PM (2012) Vitamin D and adverse pregnancy outcomes: beyond bone health and growth. Proc Nutr Soc 71, 205212.CrossRefGoogle Scholar
13.Holick, MF, Binkley, NC, Bischoff-Ferrari, HAet al. (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96, 19111930.CrossRefGoogle ScholarPubMed
14.Harris, SS (2006) Vitamin D and African Americans. J Nutr 136, 11261129.CrossRefGoogle ScholarPubMed
15.Hoang, MT, Defina, LF, Willis, BLet al. (2011) Association between low serum 25-hydroxyvitamin D and depression in a large sample of healthy adults: the Cooper Center longitudinal study. Mayo Clin Proc 86, 10501055.CrossRefGoogle Scholar
16.Gur, EB, Genc, M, Eskicioglu, Fet al. (2015) The effects of vitamin D level in pregnancy on postpartum depression. Arch Womens Ment Health 18, 263264.CrossRefGoogle Scholar
17.Huang, JY, Arnold, D, Qiu, CFet al (2014) Association of serum vitamin D with symptoms of depression and anxiety in early pregnancy. J Womens Health (Larchmt) 23, 588595.CrossRefGoogle ScholarPubMed
18.Milaneschi, Y, Shardell, M, Corsi, AMet al. (2010) Serum 25-hydroxyvitamin D and depressive symptoms in older women and men. J Clin Endocrinol Metab 95, 32253233.CrossRefGoogle ScholarPubMed
19.Polak, MA, Houghton, LA, Reeder, ALet al. (2014) Serum 25-hydroxyvitamin D concentrations and depressive symptoms among young adult men and women. Nutrients 6, 47204730.CrossRefGoogle ScholarPubMed
20.Institute of Medicine (2011) Dietary Reference Intakes for Vitamin D and Calcium. Washington, DC: National Academies Press.Google Scholar
21.Brandenbarg, J, Vrijkotte, TG, Goedhart, Get al. (2012) Maternal early-pregnancy vitamin D status is associated with maternal depressive symptoms in the Amsterdam Born Children and Their Development cohort. Psychosom Med 74, 751757.CrossRefGoogle ScholarPubMed
22.Cassidy-Bushrow, AE, Peters, RM, Johnson, DAet al. (2012) Vitamin D nutritional status and antenatal depressive symptoms in African American women. J Womens Health (Larchmt) 21, 11891195.CrossRefGoogle ScholarPubMed
23.Cunha Figueiredo, AC, Trujillo, J, Freitas-Vilela, AAet al. (2017) Association between plasma concentrations of vitamin D metabolites and depressive symptoms throughout pregnancy in a prospective cohort of Brazilian women. J Psychiatr Res 95, 18.CrossRefGoogle Scholar
24.Cox, J, Holden, J & Sagovsky, R (1987) Detection of post-natal depression: development of the ten item Edinburgh Postnatal Depression Scale. Br J Psychiatry 150, 782786.CrossRefGoogle Scholar
25.Beck, AT, Ward, CH, Mendelson, Met al. (1961) An inventory for measuring depression. Arch Gen Psychiatry 4, 561571.CrossRefGoogle ScholarPubMed
26.Williams, JA, Romero, VC, Clinton, CMet al. (2016) Vitamin D levels and perinatal depressive symptoms in women at risk: a secondary analysis of the mothers, omega-3, and mental health study. BMC Pregnancy Childbirth 16, 203.CrossRefGoogle ScholarPubMed
27.Gur, EB, Gokduman, A, Turan, GAet al. (2014) Mid-pregnancy vitamin D levels and postpartum depression. Eur J Obstet Gynecol Reprod Biol 179, 110116.CrossRefGoogle ScholarPubMed
28.Vaziri, F, Nasiri, S, Tavana, Zet al. (2016) A randomized controlled trial of vitamin D supplementation on perinatal depression: in Iranian pregnant mothers. BMC Pregnancy Childbirth 16, 239.CrossRefGoogle ScholarPubMed
29.Lamb, AR, Lutenbacher, M, Wallston, KAet al. (2018) Vitamin D deficiency and depressive symptoms in the perinatal period. Arch Womens Ment Health 21, 745755.CrossRefGoogle ScholarPubMed
30.Accortt, EE, Schetter, CD, Peters, RMet al. (2016) Lower prenatal vitamin D status and postpartum depressive symptomatology in African American women: preliminary evidence for moderation by inflammatory cytokines. Arch Womens Ment Health 19, 373383.CrossRefGoogle ScholarPubMed
31.Mozurkewich, EL, Clinton, CM, Chilimigras, JLet al. (2013) The Mothers, Omega-3, and Mental Health Study: a double-blind, randomized controlled trial. Am J Obstet Gynecol 208, 313.e1e9.CrossRefGoogle ScholarPubMed
32.Robinson, M, Whitehouse, AJ, Newnham, JPet al. (2014) Low maternal serum vitamin D during pregnancy and the risk of postpartum depression symptoms. Arch Womens Ment Health 17, 213219.CrossRefGoogle ScholarPubMed
33.Cox, J (2017) Use and misuse of the Edinburgh Postnatal Depression Scale. Arch Womens Ment Health 20, 789790.CrossRefGoogle ScholarPubMed
34.De-Regil, LM, Palacios, C, Lombardo, LKet al. (2016) Vitamin D supplementation for women during pregnancy. Cochrane Database Syst Rev issue 1, CD008873.Google Scholar
35.Rostami, M, Tehrani, FR, Simbar, Met al. (2018) Effectiveness of prenatal vitamin D deficiency screening and treatment program: a stratified randomized field trial. J Clin Endocrinol Metab 103, 29362948.CrossRefGoogle ScholarPubMed
36.Hollis, BW, Johnson, D, Hulsey, TCet al. (2011) Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res 26, 23412357.CrossRefGoogle ScholarPubMed
Figure 0

Table 1 25-Hydroxyvitamin D deficiency and postpartum depressive symptoms