here is a long and beneficial tradition of international collaboration in science and technology. There are, however, trends working against collaboration, and tensions between (for example) collaboration and competition, and European integration and increasing emphasis on national competitiveness. It is therefore important to have a clear understanding of when and in what form international collaboration is desirable. This paper considers these issues, drawing lessons from CERN – the European Laboratory for Particle Physics. CERN, which pioneered European collaboration, is now becoming in a sense a world organization. Physicists from 47 countries will participate in experiments at CERN's next project, the Large Hadron Collider (LHC), which is set to be the first megascience project constructed by a global partnership, driven ‘bottom up’ by the scientists involved. CERN's experience with the LHC could provide an excellent precedent for other projects.