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Exploring educational inequalities in hypertension control, salt knowledge and awareness, and patient advice: insights from the WHO STEPS surveys of adults from nine Eastern European and Central Asian countries

Published online by Cambridge University Press:  13 February 2023

Katerina Maximova*
Affiliation:
MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, 209 Victoria Street, Toronto, ON M5B 1T8, Canada Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
Enrique Loyola Elizondo
Affiliation:
World Health Organization European Office for the Prevention and Control of Non-Communicable Diseases (NCD Office), Division of Country Health Programmes, WHO Regional Office for Europe, Moscow, Russia
Holly Rippin
Affiliation:
World Health Organization European Office for the Prevention and Control of Non-Communicable Diseases (NCD Office), Division of Country Health Programmes, WHO Regional Office for Europe, Moscow, Russia
João Breda
Affiliation:
World Health Organization European Office for the Prevention and Control of Non-Communicable Diseases (NCD Office), Division of Country Health Programmes, WHO Regional Office for Europe, Moscow, Russia
Francesco P Cappuccio
Affiliation:
WHO Collaborating Centre for Nutrition, University of Warwick, Coventry, UK Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, UK
Morteza Hajihosseini
Affiliation:
School of Public Health, University of Alberta, Edmonton, Canada
Kremlin Wickramasinghe
Affiliation:
World Health Organization European Office for the Prevention and Control of Non-Communicable Diseases (NCD Office), Division of Country Health Programmes, WHO Regional Office for Europe, Moscow, Russia
Irina Novik
Affiliation:
Republican Scientific and Practical Center of Medical Technologies, Informatization, Management and Economics of Public Health (RSPC MT), Minsk, Belarus
Vital Pisaryk
Affiliation:
Republican Scientific and Practical Center of Medical Technologies, Informatization, Management and Economics of Public Health (RSPC MT), Minsk, Belarus
Lela Sturua
Affiliation:
National Center for Disease Control and Public Health (NCDC) of Georgia, Tbilisi, Georgia
Ainura Akmatova
Affiliation:
Department of Public Health, Ministry of Health, Bishkek, Kyrgyzstan
Galina Obreja
Affiliation:
Department of Social Medicine and Management, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova
Saodat Azimzoda Mustafo
Affiliation:
State Research Institute of Gastroenterology, Ministry of Health and Social Protection of Population, Dushanbe, Republic of Tajikistan
Banu Ekinci
Affiliation:
Department of Chronic Disease and Elderly Health, General Directorate of Public Health of Ministry of Health of Turkey, Ankara, Turkey
Toker Erguder
Affiliation:
WHO Country Office in Turkey, Ankara, Turkey
Shukhrat Shukurov
Affiliation:
Central Project Implementation Bureau of the Health-3 Project, Tashkent, Uzbekistan
Gahraman Hagverdiyev
Affiliation:
Public Health and Reforms Center, Ministry of Health, Baku, Azerbaijan
Diana Andreasyan
Affiliation:
National Institute of Health, Ministry of Health, Yerevan, Armenia
Carina Ferreira-Borges
Affiliation:
World Health Organization European Office for the Prevention and Control of Non-Communicable Diseases (NCD Office), Division of Country Health Programmes, WHO Regional Office for Europe, Moscow, Russia
Nino Berdzuli
Affiliation:
World Health Organization European Office for the Prevention and Control of Non-Communicable Diseases (NCD Office), Division of Country Health Programmes, WHO Regional Office for Europe, Moscow, Russia
Stephen Whiting
Affiliation:
World Health Organization European Office for the Prevention and Control of Non-Communicable Diseases (NCD Office), Division of Country Health Programmes, WHO Regional Office for Europe, Moscow, Russia
Natalia Fedkina
Affiliation:
World Health Organization European Office for the Prevention and Control of Non-Communicable Diseases (NCD Office), Division of Country Health Programmes, WHO Regional Office for Europe, Moscow, Russia
Ivo Rakovac
Affiliation:
World Health Organization European Office for the Prevention and Control of Non-Communicable Diseases (NCD Office), Division of Country Health Programmes, WHO Regional Office for Europe, Moscow, Russia
*
*Corresponding author: Email [email protected]
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Abstract

Objective:

To inform strategies aimed at improving blood pressure (BP) control and reducing salt intake, we assessed educational inequalities in high blood pressure (HBP) awareness, treatment and control; physician’s advice on salt reduction; and salt knowledge, perceptions and consumption behaviours in Eastern Europe and Central Asia.

Design:

Data were collected in cross-sectional, population-based nationally representative surveys, using a multi-stage clustered sampling design. Five HBP awareness, treatment and control categories were created from measured BP and hypertension medication use. Education and other variables were self-reported. Weighted multinomial mixed-effects regression models, adjusted for confounders, were used to assess differences across education categories.

Settings:

Nine Eastern European and Central Asian countries (Armenia, Azerbaijan, Belarus, Georgia, Kyrgyzstan, Republic of Moldova, Tajikistan, Turkey and Uzbekistan).

Participants:

Nationally representative samples of 30 455 adults aged 25–65 years.

Results:

HBP awareness, treatment and control varied substantially by education. The coverage of physician’s advice on salt was less frequent among participants with lower education, and those with untreated HBP or unaware of their HBP. The education gradient was evident in salt knowledge and perceptions of salt intake but not in salt consumption behaviours. Improved salt knowledge and perceptions were more prevalent among participants who received physician’s advice on salt reduction.

Conclusions:

There is a strong education gradient in HBP awareness, treatment and control as well as salt knowledge and perceived intake. Enhancements in public and patient knowledge and awareness of HBP and its risk factors targeting socio-economically disadvantaged groups are urgently needed to alleviate the growing HBP burden in low- and middle-income countries.

Type
Research Paper
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of The Nutrition Society

The global target of a 25 % relative reduction in the prevalence of raised blood pressure (BP) by 2025 adopted by the WHO(1) is supported by all European countries(2). High blood pressure (HBP) or hypertension is a major modifiable risk factor for CVD and a leading risk factor for global deaths(3). In the WHO European Region, 54 % of CVD burden is attributable to HBP(4) and 28 % of adults have HBP (≥140/90 mmHg), with the highest prevalence in Eastern European and Central Asian countries where it frequently surpasses 40 %(3). The HBP burden has doubled worldwide since 1990, with most of the increases occurring in low- and middle-income countries. This burden is projected to further increase by 60 % by 2025, disproportionately affecting low- and middle-income settings(3). Despite the high prevalence, many individuals are unaware they have HBP, and among those who are aware, many are untreated or uncontrolled, particularly in low- and middle-income countries(3,5) .

A substantial body of evidence convincingly implicates excess salt (sodium chloride) intake in the pathogenesis of HBP and the atherosclerotic process underlying CVD(Reference Aburto, Ziolkovska and Hooper6). Current levels of dietary salt consumption grossly exceed human physiological needs(Reference Adrogue and Madias7), with excess salt consumption being highly prevalent worldwide(8). In countries of the WHO European Region, average daily salt intake is 2–3 times above the maximum daily recommended intake of <5 g/d and is particularly high in Central Asian and Eastern European countries(Reference Powles, Fahimi and Micha9). Improved recognition of the importance of salt has been identified as one of the major public health and medical challenges in the prevention and treatment of HBP and CVD.

Population-wide reduction of dietary salt consumption is considered to be the most cost-effective intervention to help achieve the global target of a 30 % relative reduction in mean population intake of salt/sodium(Reference Asaria, Chisholm and Mathers10,Reference Bibbins-Domingo, Chertow and Coxson11) and has been advocated by the WHO as a crucial strategy for tackling the global burden of disease(8,12) . Several countries have adopted formal policies aimed at reducing salt intake in the general population, with implementation of comprehensive national programmes shown to lead to approximately a 10 % reduction in salt intake and significant reductions in population BP levels, the incidence of CVD events, and CVD mortality(Reference Santos, Tekle and Rosewarne13). In the WHO European Region, twenty-six out of fifty-three countries had an operational salt reduction policy in 2013, although countries in Eastern Europe and Central Asia are lagging behind(14). While comprehensive and multifaceted efforts that include food reformulation, front-of-pack labelling, marketing limitations and surveillance are needed to lower dietary salt consumption, improvements in salt knowledge and perceptions, combined with primary health care counselling and advice to reduce salt intake, are essential components of all successful population-wide salt reduction strategies(Reference Hyseni, Elliot-Green and Lloyd-Williams15).

Promoting health and well-being is a core priority of the WHO General and European Programme of Work(16,17) , and measuring and reducing socio-economic inequalities, leaving no one behind, is a major goal of the European Programme of Work 2020–2025(17). Socio-economic inequalities (whether based on education, income or occupation) in non-communicable disease (NCD) morbidity and mortality have been previously documented, with CVD and HBP disproportionately affecting socio-economically disadvantaged groups(18). However, little is known about socio-economic inequalities in HBP awareness, treatment and control, salt knowledge, perceptions and consumption behaviours, and physician’s advice on salt reduction among adults across different socio-economic groups(Reference Powles, Fahimi and Micha9), and virtually no evidence on socio-economic gradients exist in Eastern Europe and Central Asia. In this study, we examined educational inequalities in HBP awareness, treatment and control, physician’s advice on salt reduction, and salt knowledge, perceptions of salt intake and salt consumption behaviours among adults from nine Eastern European and Central Asian countries. We ask the question whether adults with lower education will have (a) lower prevalence of HBP awareness, treatment and control, (b) lower prevalence of physician’s advice on salt reduction, and (c) poorer salt knowledge, perceptions and behaviours, compared to those with higher education.

Methods

Study population

Data from nine countries in Eastern Europe and Central Asia (Armenia, Azerbaijan, Belarus, Georgia, Kyrgyzstan, Republic of Moldova, Tajikistan, Turkey and Uzbekistan) were collected in cross-sectional, population-based national household surveys through the WHO STEPwise approach to Surveillance (WHO STEPS). The WHO STEPS is the WHO-recommended framework for NCD surveillance. The STEPS survey methods are described in depth in the WHO STEPS Surveillance Manual(19), and details are given in the individual country reports(20). Briefly, a multi-stage clustered sampling design was employed to draw a nationally representative sample in each country. Primary, secondary and tertiary sampling units represented geographical divisions (e.g. provinces, regions and villages). A limited number of households (usually 12–20) in each primary selection unit were selected, and one adult per household was randomly chosen for participation in the survey. Due to the ways data were collected in each country, the study population included adults aged 25–65 years, 15–69 years and 18–65 years in Kyrgyzstan, Turkey, Uzbekistan, respectively, and 18–69 in six other countries (Table 1). Participation was voluntary, and informed consent was obtained using country-specific language forms. In addition, to protect the confidentiality of collected and archived data, records were anonymised with unique identifiers assigned to participants. Ethical approval was obtained in each country before survey administration.

Table 1 Overview of WHO STEPS surveys in nine Eastern European and Central Asian countries

LMIC, lower-middle-income country; UMIC, upper-middle-income country.

* The World Bank income level in the year of the survey.

Survey instrument

Data were collected using the STEPS survey instrument, which is both standardised and adaptable to each country’s priorities, needs and resources(Reference Riley, Guthold and Cowan21). The information was collected using standardised questionnaire via face-to-face interviews at the participant’s home by interviewers trained by the WHO. The questionnaire includes questions about socio-demographic characteristics (age, sex, level of education, marital status and work status), and NCD risk factors such as consumption of vegetables and fruit, salt-related behaviours and perceptions, physical activity, history of risk factor measurements and diagnosis for selected NCD, and advice from health care professionals regarding risk factors. Standard WHO and internationally recognised definitions and measures are used in order to maintain comparability. The interview is followed by basic physical measurements, including height, weight, waist circumference and BP, collected by trained interviewers at respondent’s home(19,20) .

Measures

BP was measured at the end of the home questionnaire, using a standardised protocol. Trained interviewers assessed BP in the sitting position, on the left arm, after the participant had voided their bladder, fasted and refrained from drinking coffee or smoking for >30 min and following a 5-min rest after interview, using digital sphygmomanometers and universal sized cuffs. Three readings were taken, at least 3 min apart, and the second and third readings were used to calculate an individual’s mean value. Five hypertension awareness, treatment and control categories were created as follows: normotensive (BP < 140/90 mmHg, not on HBP medication); hypertensive treated, controlled (BP < 140/90 mmHg, on HBP medication); hypertensive treated, uncontrolled (BP ≥ 140/90 mmHg, on HBP medication); hypertensive untreated, aware (BP ≥ 140/90 mmHg, not on HBP medication, aware of HBP); and hypertensive untreated, unaware (BP ≥ 140/90 mmHg, not on HBP medication, not aware of HBP)(19).

Participants reported the highest level of education completed using national education categories, which were mapped to the UNESCO International Standard Classification of Education (ISCED). ISCED provides a comprehensive framework of uniform and internationally agreed definitions to facilitate comparisons of education systems across countries(22). Using country-specific 2011 ISCED mappings, participant’s education was categorised into three groupings, corresponding to levels 0–2 (less than high school), 3–5 (high school) and 6–8 (college/university/postgraduate degree)(22).

Salt knowledge was based on participants’ answers to the following questions: ‘Do you think that too much salt in your diet could cause a health problem?’ (yes/no), and ‘How important to you is lowering the salt in your diet?’ (very important/somewhat important/not at all important). Participants’ salt consumption behaviours were based on three questions: ‘How often do you add salt/salty sauce to your food right before eating it?’, ‘How often is salt/salty seasoning/salty sauce adding in cooking or preparing foods in your household?’ and ‘How often do you eat processed foods high in salt?’ (always, often, sometimes, rarely and never). Lastly, perceptions of salt intake were based on the following question: ‘How much salt or salty sauce do you think you consume?’ (far too much, too much, just the right amount, too little, far too little). Participants reported if they received physician’s advice to reduce salt intake: ‘During the past 3 years, has your doctor advised you to reduce salt in your diet?’ (yes/no).

Participants reported their age, sex and number of people living in household. Marital status was categorised as never married, currently married or cohabiting, and other (separated, divorced and widowed). Work status categories included employed, non-paid, homemaker, student, retired and unemployed. Participant reported their typical weekly consumption of vegetables and fruit, from which the number of daily servings was derived. Physical activity was assessed using the Global Physical Activity Questionnaire (GPAQ)(Reference Bull, Maslin and Armstrong23), and participants were categorised if they meet the WHO recommendation for health-enhancing physical activity of 150 min of moderate or 75 min of vigorous physical activity weekly, or equivalent(24). Following BP assessment, anthropometric measurements were also taken by trained data collectors, with standing height and weight measured to the nearest 1 cm and 100 g, using a stadiometer and a calibrated balance beam scale. Overweight and obesity were based on BMI ≥ 25 and 30 kg/m2, respectively.

Data analysis

To enable comparisons across countries, age was restricted to 25–65 years, resulting in the following sample sizes available for analysis: Armenia n 1878, Azerbaijan n 4700, Belarus n 4224, Georgia n 3399, Kyrgyzstan n 2623, Republic of Moldova n 3983, Tajikistan n 2237, Turkey n 4208 and Uzbekistan n 3203 (Table 1). To estimate the national prevalence of study outcomes (hypertension control, physician’s advice to reduce salt intake, and salt knowledge, perceptions of salt intake and salt consumption behaviours), percentages were derived using survey design weights developed by the WHO to account for multi-stage cluster design and non-response while considering the age and sex distribution of the population so that the results are nationally representative. Next, to assess differences in these percentages across education groupings (corresponding to levels 0–2, 3–5 and 6–8 of country-specific 2011 ISCED mappings), generalised linear mixed-effects regression models with the ‘logit’ link function using survey design weights and random intercepts (i.e. weighted multinomial mixed-effects regression) were applied to the data. Separate models were fitted for each outcome (hypertension control, physician’s advice to reduce salt intake, and salt knowledge, perceptions of salt intake and salt consumption behaviours), with education groupings as an independent variable, and were adjusted for age, sex, marital status, weight status (normal weight, overweight and obese), and daily servings of vegetables and fruit. The survey package in R 3.5.0 software (GNU General Public License) was used to account for the complex survey design, and lme4 and broom packages were used for weighted multinomial mixed-effects regression models. All analyses were stratified by country to facilitate comparisons and acknowledge country-specific contexts for HBP control and cultural factors around salt intake. Significance level was set at α = 0·05, and statistical significance was set at P < 0·05.

Results

Participants were, on average, 41–42 years old, 45–51 % were female, and majority were married (Table 2). About one-fifth to one-quarter of participants had completed some form of post-secondary education, and this proportion varied from 13·5 % in Uzbekistan to 44·3 % in Azerbaijan. More than half were overweight or obese, with the proportion of overweight and obese participants ranging from 52·4 % in Armenia to 71·7 % in Turkey. Consumption of vegetables and fruit was well below the recommended levels, and the proportion of participants consuming at least five servings daily ranged between 12·2 % in Turkey and 39·8 % in Tajikistan. Majority of participants did not meet the WHO recommendation for weekly physical activity(24), with the proportion ranging from 9·4 % in the Republic of Moldova to 41·4 % in Turkey. Over half were normotensive, with Turkey having the highest proportion of participants with normal BP (74·7 %). The remainder of the participants were hypertensive, and many were untreated and unaware of their HBP, particularly in Tajikistan, Armenia and Kyrgyzstan (30·1 %, 28·9 % and 25·6 %, respectively). HBP awareness, treatment and control varied by education (Fig. 1). In most countries, a higher proportion of participants with less than high school or high school education had worse HBP awareness, treatment and control, particularly among those with treated but uncontrolled HBP and those who were untreated and unaware of their HBP.

Table 2 Characteristics of study participants

Fig. 1 National prevalence of hypertension awareness, treatment and control according to education. Lower = less than high school. Medium = high school. Higher = college/university/postgraduate. *P-values derived from weighted multinomial mixed-effects regression models, adjusted for age, sex, marital status, weight status (normal weight, overweight and obese), and daily servings of vegetables and fruit

The proportion of participants who received physician’s advice to reduce salt intake varied by education in Armenia, Georgia, Kyrgyzstan and Tajikistan (Table 3). A lower proportion of participants with less than high school education received physician’s advice to lower salt intake in Armenia, Georgia and Tajikistan. Importantly, there was a difference in receiving physician’s advice to lower salt intake in all countries across categories of HBP awareness, treatment and control (Table 3). Participants with treated HBP (regardless of whether it was controlled or uncontrolled) were most likely to receive physician’s advice to lower salt intake. Both normotensives and hypertensive participants who were unaware of HBP were least likely to receive advice to reduce salt intake in all countries. Among participants aware of HBP but not receiving treatment, the rates were lower than among those treated, but still higher than among normotensives and those unaware of HBP.

Table 3 Proportion of participants who received physician’s advice to reduce salt intake according to education and hypertension awareness, treatment and control status

* From weighted multinomial mixed-effects regression models, adjusted for age, sex, marital status, weight status (normal weight, overweight and obese), and daily servings of vegetables and fruit.

Participants with lower education frequently reported lower levels of salt knowledge (Fig. 2). Salt knowledge (‘Think too much salt in own’s diet could cause a health problem’ and ‘Consider lowering salt in own’s diet as very important’) improved consistently with higher education in almost all countries. In terms of perceptions of salt intake, a higher proportion of participants with lower education considered that they consume far too much or too much salt in Belarus, Georgia, Tajikistan and Uzbekistan. However, salt consumption behaviours did not show a consistent education gradient. Participants with lower education reported more frequently that they always/often add salt before eating than those with higher education in Azerbaijan, Belarus and Georgia. Always/often adding salt during cooking was more prevalent among participants with higher than lower education in Turkey (as well as frequent consumption of processed foods high in salt), and among participants with medium education in Armenia and Georgia.

Fig. 2 National prevalence of salt knowledge, perceptions of salt intake and salt consumption behaviours according to education. Lower = less than high school. Medium = high school. Higher = college/university/postgraduate. *P-values derived from weighted multinomial mixed-effects regression models, adjusted for age, sex, marital status, weight status (normal weight, overweight and obese), and daily servings of vegetables and fruit

Salt knowledge was higher among those receiving physician’s advice to reduce salt intake (Fig. 3). In all countries, a higher proportion of participants reported that too much salt in their own diet could cause a health problem, and that lowering salt in their own diet is very important if they received physician’s advice to lower salt intake. In terms of perceptions of salt intake, a much higher proportion of participants reported thinking they consume far too much or too much salt if they received physician’s advice to reduce salt intake in Armenia, Belarus, Georgia, Kyrgyzstan and Turkey. Nonetheless, frequent salt consumption (always/often adding salt to food before eating or during cooking and eating processed foods high in salt) did not show a consistent improvement among those receiving physician’s advice to reduce salt intake. Better salt consumption behaviours among participants who received physician’s advice to reduce salt intake were observed only in the Republic of Moldova, Turkey and Uzbekistan.

Fig. 3 National prevalence of salt knowledge, perceptions of salt intake and salt consumption behaviours according to physician’s advice to reduce salt intake. Yes = received physician’s advice to reduce salt intake during the past 3 years. No = did not receive physician’s advice to reduce salt intake during the past 3 years. *P-values derived from weighted multinomial mixed-effects regression models, adjusted for age, sex, marital status, weight status (normal weight, overweight and obese), and daily servings of vegetables and fruit

Discussion

This study reports for the first time on nationally representative educational inequalities in HBP awareness, treatment and control as well as in salt knowledge, perceptions and behaviours from nine countries in Eastern Europe and Central Asia. Four key findings emerge from this study. First, the national prevalence of hypertension was high, and HBP treatment and control rates varied by country but were very low in general. Substantial differences exist in HBP awareness, treatment and control across the educational groupings, with participants with lower levels of education having lower levels of HBP awareness, treatment and control. Second, participants with diagnosed and treated HBP received the advice by a health care professional to reduce salt intake more often, although the coverage of physician’s advice on salt reduction was low in all groups. Third, knowledge of harmful effects of salt on health was lower among participants with lower education, but the education gradient in salt consumption behaviours was less pronounced and the direction of association was inconsistent. Lastly, knowledge of harmful effects of salt was more prevalent among participants who received advice on salt reduction from health care professionals, but the impact of physician’s advice was not evident for salt consumption behaviours.

The suboptimal HBP awareness, treatment and control, whereby many participants with diagnosed hypertension do not have their HBP controlled despite being treated, and a large proportion of hypertensive participants either do not have their HBP treated or are unaware of their HBP, is concerning but corroborates the emerging evidence from low- and middle-income settings(Reference Beaney, Burrell and Castillo25,Reference Mohanty, Pedgaonkar and Upadhyay26) . While evidence on HBP awareness, treatment and control in low- and middle-income settings is scant, the findings align with the rates observed in high-income countries in the 1980s and early 1990s, whereby treatment rates were at most 40 % and control rates were less than 25 %(5). Importantly, our study demonstrated a large and consistent educational gradient in HBP awareness, treatment and control(Reference Mohanty, Pedgaonkar and Upadhyay26,Reference Siven, Niiranen and Aromaa27) . Overall, results highlight that improvements in HBP awareness, treatment and control are urgently needed in low- and middle-income settings(Reference Redon, Mourad and Schmieder28). Indeed, evidence from high-income countries suggests that hypertension awareness, treatment rate and control rate can be improved rapidly following implementation of national programmes for hypertension education and/or health check-ups and identifies tailored knowledge dissemination (targeting socio-economically disadvantaged, hard-to-reach population subgroups) as an important ingredient of success of national education programmes(5).

Results from this study identify important gaps in the coverage of advice on salt reduction by health care professionals. Physician’s advice is a well-established strategy for improving HBP control(Reference Inui, Yourtee and Williamson29,Reference Dawes, Kaczorowski and Swanson30) . However, we found that the coverage of physician’s advice to reduce salt intake was less frequent among participants with lower education as well as those who were hypertensive but were untreated or unaware of their HBP. This lack of physician’s advice poses a double threat, since a strong socio-economic gradient (whether based on education and other dimensions of socio-economic status (SES) such as income or occupation) exists in the prevalence of HBP, and lower SES groups bear disproportionately higher rates of CVD mortality, compared with higher SES groups(18,31) . The findings from this study corroborate this evidence and highlight the need for improvements in the population-wide coverage of medical advice and awareness raising on salt reduction, with greater emphasis on targeting those with lower education and untreated HBP (e.g. through primary health care multidisciplinary collaboration between physicians, nurses and pharmacists(Reference Earl and Henstenburg32,Reference Proia, Thota and Njie33) and pharmacy-based interventions(Reference Santschi, Chiolero and Colosimo34)). The feasibility of adopting evidence-based approaches to implement in countries in Eastern Europe and Central Asia should be investigated using modern implementation science methodologies(Reference Breda, Wickramasinghe and Peters35,Reference Peters, Peters and Wickramasinghe36) .

In this study, we documented an education gradient in salt knowledge, which may contribute to the high burden of CVD among lower SES groups. Overall, the personal risk associated with salt consumption was not salient for many participants, and the perception of personal risk was socio-economically patterned. Risk reduction knowledge is often strongly socio-economically patterned and is lowest among those with low SES(Reference Andersson and Leppert37). Recent evidence from Italy and the UK in general populations also find socio-economic differences in salt knowledge and awareness of salt reduction guidelines(Reference Iaccarino Idelson, D’Elia and Cairella38,Reference Millett, Laverty and Stylianou39) . Since a lack of knowledge is commonly identified as a barrier to salt restriction in adults with hypertension(Reference Gee, Bienek and Campbell40), and better salt awareness and self-control of salt intake have been linked to lower prevalence of hypertension in general adult populations(Reference Baharudin, Ambak and Othman41), our findings make an important contribution to the nascent literature on socio-economic inequalities in salt knowledge in Eastern European and Central Asian countries.

Moreover, the translation of improvements in knowledge and perceptions into better lifestyle behaviours depends on individual social and economic resources which may or may not allow individuals to benefit from such interventions(Reference Lynch, Kaplan and Salonen42). Our findings from nine countries in Eastern Europe and Central Asia reveal the lack of consistent patterns in salt consumption behaviours across education groupings, despite an education gradient in knowledge and perceptions of one’s own salt intake. Nonetheless, previous studies have demonstrated a socio-economic gradient in salt consumption in the UK, Italy and Montenegro when salt intake was measured through dietary recall or a 24-h urine collection(Reference Ji and Cappuccio43Reference D’Elia, Brajovic and Klisic45). Overall, the study findings suggest that, in addition to evidence-informed programmes to improve salt knowledge(Reference Santos, Tekle and Rosewarne13,Reference Webster, Santos and Hogendorf46) , other approaches are needed to optimise the effectiveness of country-specific salt reduction strategies and maximise population impact on behaviour change(47). Specifically, legislative and regulatory interventions that engage industry to limit salt content in processed foods through product reformulation are also needed to facilitate development and implementation of comprehensive population-wide salt reductions strategies(Reference Magnusson and Patterson48) and to reduce health inequalities(Reference Gillespie, Allen and Guzman-Castillo49).

The strengths of this study include large and nationally representative samples, standardised and state-of-the-art questionnaire as well as objective and standardised measurement of biological risk factors including BP, weight and height. Several limitations warrant consideration. Although the data were adjusted for non-response rate, there is a possibility that non-respondents have different characteristics than respondents in the surveys. Better knowledge of salt effects on health lead to better health outcomes via diets low in salt. Measures of salt knowledge, participants’ perceptions of salt intake and salt consumption behaviours were all self-reported. We cannot rule out the possibility of recall or social desirability bias introducing measurement error. The WHO STEPS surveys do not have a reliable objective measure of salt/Na intake at the individual level. It is possible that an education gradient in salt consumption may be detected if salt intake was measured through dietary recall or a 24-h urine collection. We are also not able to disentangle whether the gaps in the coverage of physician’s advice to reduce salt intake among participants with lower education as well as those who were hypertensive but were untreated or unaware of their HBP may be due to issues of reduced frequency of accessing health care or health promotion services, recall bias or physician’s bias in providing care. Future research should investigate the sources of the discrepancies in the coverage of physician’s advice on salt reduction by health care professionals. Finally, although education is a robust indicator of SES (defined as one’s material and social standing relative to others), only inequalities based on education, but not other dimensions of SES (e.g. income and occupation), could be considered due to the data parameters.

The findings suggest that HBP awareness, treatment and control were low in Eastern European and Central Asian countries, and there was a strong education gradient in HBP awareness, treatment and control as well as salt knowledge and perceived intake. Results from this study underscore the urgent need for enhancements in public and patient knowledge and awareness of HBP and its risk factors, targeting socio-economically disadvantaged groups with lower education to help alleviate the high and growing HBP burden in low- and middle-income countries in the WHO European Region and worldwide. The findings reveal educational inequalities in physician’s advice on salt reduction. Given that physician’s advice is a promising intervention strategy, future implementation science research studies should investigate its potential to optimise the delivery of existing brief interventions and patient education programmes in the primary health care settings by reaching the most high-risk and socio-economically disadvantaged segments of the population while considering local primary health care systems, level of development, cultural factors and resources available for health promotion. Other potential avenues for reducing salt intake at the population level may include legislative and regulatory approaches, which rely less on individual uptake and have been shown to contribute to health improvements in an equitable manner(Reference Cappuccio, Capewell and Lincoln50).

Acknowledgements

Acknowledgements: The authors would like to thank the WHO STEPS country teams in Armenia, Azerbaijan, Belarus, Georgia, Kyrgyzstan, Republic of Moldova, Tajikistan, Turkey and Uzbekistan for organising and conducting the survey. Authorship: All listed authors contributed to study design, drafted and revised the article, and gave their final approval of the version submitted for publication. K.M., I.R. and E.L.E. conceived and designed the study. E.L.E. and I.R. supervised data collection, management and validation. I.N., V.P., L.S., A.A., G.O., S.A.M., B.E., T.E., S.S., G.H. and D.A. oversaw data collection and contributed to data interpretation. K.M., M.H. and I.R. conducted the statistical analyses and drafted the manuscript with support from E.L.E., H.R., N.F., H.R., K.W., J.J.B., F.P.C., C.F.B. and S.W. contributed to interpretation and manuscript development. All authors reviewed and approved the final manuscript. Ethics of human subject participation: This study was conducted according to the guidelines laid down in the Declaration of Helsinki, and all procedures involving research study participants were reviewed and approved by the Ethics Committees in the nine countries and the WHO. The participants provided their written informed consent to participate in this study.

Financial support:

This study has been conducted with the financial assistance of the Government of the Russian Federation within the context of the WHO European Office for the Prevention and Control of Noncommunicable Diseases. Funding sources of individual STEPS surveys are acknowledged in published reports.

Conflicts of interest:

There are no conflicts of interest.

Footnotes

Disclaimer: This paper was published as part of a Supplement in the Journal of Public Health Nutrition, publication of which was supported by the World Health Organization European Office for the Prevention and Control of Noncommunicable Diseases. The papers included in this supplement were invited by the Guest Editors and have undergone the standard journal formal review process. They may be cited. The authors alone are responsible for the views expressed in this publication and they do not necessarily represent the views, decisions or policies of the institutions with which they are affiliated.

References

United Nations General Assembly (2018) Political Declaration of the Third High-Level Meeting of the General Assembly on the Prevention and Control of Non-Communicable Diseases. https://digitallibrary.un.org/record/1648984?ln=en (accessed July 2022).Google Scholar
United Nations General Assembly (2014) Outcome Document of the High-Level Meeting of the General Assembly on the Comprehensive Review and Assessment of the Progress Achieved in the Prevention and Control of Non-Communicable Diseases. https://digitallibrary.un.org/record/774662?ln=en (accessed July 2022).Google Scholar
NCD Risk Factor Collaboration (NCD-RisC) (2021) Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. Lancet 398, 957980.10.1016/S0140-6736(21)01330-1CrossRefGoogle Scholar
Global Burden of Disease Collaboration Network (2017) Global Burden of Disease Study 2017 (GBD 2017) Results. http://ghdx.healthdata.org/gbd-results-tool?params=gbd-api-2017-permalink/bb5a7afe6a241fa30b51266b977ecdd5 (accessed July 2022).Google Scholar
NCD Risk Factor Collaboration (NCD-RisC) (2019) Long-term and recent trends in hypertension awareness, treatment, and control in 12 high-income countries: an analysis of 123 nationally representative surveys. Lancet 394, 639651.10.1016/S0140-6736(19)31145-6CrossRefGoogle Scholar
Aburto, NJ, Ziolkovska, A, Hooper, L et al. (2013) Effect of lower sodium intake on health: systematic review and meta-analyses. BMJ 346, f1326.10.1136/bmj.f1326CrossRefGoogle ScholarPubMed
Adrogue, HJ & Madias, NE (2007) Sodium and potassium in the pathogenesis of hypertension. N Engl J Med 356, 19661978.CrossRefGoogle ScholarPubMed
World Health Organization & Regional Office for Europe (2020) Accelerating Salt Reduction in Europe: A Country Support Package to Reduce Population Salt Intake in the WHO European Region. https://apps.who.int/iris/handle/10665/340028 (accessed July 2022).Google Scholar
Powles, J, Fahimi, S, Micha, R et al. (2013) Global, regional and national sodium intakes in 1990 and 2010: a systematic analysis of 24 h urinary sodium excretion and dietary surveys worldwide. BMJ Open 3, e003733.CrossRefGoogle ScholarPubMed
Asaria, P, Chisholm, D, Mathers, C et al. (2007) Chronic disease prevention: health effects and financial costs of strategies to reduce salt intake and control tobacco use. Lancet 370, 20442053.10.1016/S0140-6736(07)61698-5CrossRefGoogle ScholarPubMed
Bibbins-Domingo, K, Chertow, GM, Coxson, PG et al. (2010) Projected effect of dietary salt reductions on future cardiovascular disease. N Engl J Med 362, 590599.10.1056/NEJMoa0907355CrossRefGoogle ScholarPubMed
World Health Organization (2010) Creating an Enabling Environment for Population-Based Salt Reduction Strategies: Report of a Joint Technical Meeting Held by WHO and the Food Standards Agency, United Kingdom, July 2010. https://apps.who.int/iris/handle/10665/44474 (accessed July 2022).Google Scholar
Santos, JA, Tekle, D, Rosewarne, E et al. (2021) A systematic review of salt reduction initiatives around the world: a midterm evaluation of progress towards the 2025 global non-communicable diseases salt reduction target. Adv Nutr 12, 17681780.10.1093/advances/nmab008CrossRefGoogle ScholarPubMed
World Health Organization & Regional Office for Europe (2013) Mapping Salt Reduction Initiatives in the WHO European Region. https://www.euro.who.int/__data/assets/pdf_file/0009/186462/Mapping-salt-reduction-initiatives-in-the-WHO-European-Region.pdf (accessed July 2022).Google Scholar
Hyseni, L, Elliot-Green, A, Lloyd-Williams, F et al. (2017) Systematic review of dietary salt reduction policies: evidence for an effectiveness hierarchy? PLoS ONE 12, e0177535.10.1371/journal.pone.0177535CrossRefGoogle ScholarPubMed
World Health Organization (2019) Thirteenth General Programme of Work 2019–2023. Geneva: WHO. https://www.who.int/about/what-we-do/thirteenth-general-programme-of-work-2019–2023 (accessed July 2022).Google Scholar
World Health Organization & Regional Office for Europe (2013) European Programme of Work, 2020–2025 – “United Action for Better Health in Europe” (EUR/RC70/11). https://apps.who.int/iris/bitstream/handle/10665/333908/70wd11e-EPW-200673.pdf?sequence=1&isAllowed=y (accessed July 2022).Google Scholar
World Health Organization (2021) Noncommunicable Diseases. Fact Sheet. https://www.who.int/news-room/fact-sheets/detail/noncommunicable-diseases (accessed July 2022).Google Scholar
World Health Organization (2020) The WHO STEPwise Approach to Noncommunicable Disease Risk Factor Surveillance. WHO STEPS Surveillance Manual. https://www.who.int/teams/noncommunicable-diseases/surveillance/systems-tools/steps/manuals (accessed July 2022).Google Scholar
World Health Organization (2022) Noncommunicable Diseases and their Risk Factors: STEPS Country Reports. https://ghdx.healthdata.org/series/steps-noncommunicable-disease-risk-factors-survey (accessed July 2022).Google Scholar
Riley, L, Guthold, R, Cowan, M et al. (2016) The World Health Organization STEPwise approach to noncommunicable disease risk-factor surveillance: methods, challenges, and opportunities. Am J Public Health 106, 7478.10.2105/AJPH.2015.302962CrossRefGoogle ScholarPubMed
UNESCO & Institute for Statistics (2012) International Standard Classification of Education (ISCED) 2011 (UIS/2012/INS/10/REV). http://uis.unesco.org/sites/default/files/documents/international-standard-classification-of-education-isced-2011-en.pdf (accessed July 2022).Google Scholar
Bull, FC, Maslin, TS & Armstrong, T (2009) Global physical activity questionnaire (GPAQ): nine country reliability and validity study. J Phys Act Health 6, 790804.CrossRefGoogle ScholarPubMed
World Health Organization (2010) Global Recommendations on Physical Activity for Health. https://www.who.int/publications/i/item/9789241599979 (accessed July 2022).Google Scholar
Beaney, T, Burrell, LM, Castillo, RR et al. (2019) May measurement month 2018: a pragmatic global screening campaign to raise awareness of blood pressure by the International Society of Hypertension. Eur Heart J 40, 20062017.CrossRefGoogle ScholarPubMed
Mohanty, SK, Pedgaonkar, SP, Upadhyay, AK et al. (2021) Awareness, treatment, and control of hypertension in adults aged 45 years and over and their spouses in India: a nationally representative cross-sectional study. PLoS Med 18, e1003740.10.1371/journal.pmed.1003740CrossRefGoogle ScholarPubMed
Siven, SS, Niiranen, TJ, Aromaa, A et al. (2015) Social, lifestyle and demographic inequalities in hypertension care. Scand J Public Health 43, 246253.10.1177/1403494815571031CrossRefGoogle ScholarPubMed
Redon, J, Mourad, JJ, Schmieder, RE, et al. (2016) Why in 2016 are patients with hypertension not 100 % controlled? A call to action. J Hypertens 34,14801488.10.1097/HJH.0000000000000988CrossRefGoogle Scholar
Inui, TS, Yourtee, EL & Williamson, JW (1976) Improved outcomes in hypertension after physician tutorials. A controlled trial. Ann Intern Med 84, 646651.10.7326/0003-4819-84-6-646CrossRefGoogle ScholarPubMed
Dawes, MG, Kaczorowski, J, Swanson, G et al. (2010) The effect of a patient education booklet and BP ‘tracker’ on knowledge about hypertension. A randomized controlled trial. Fam Pract 27, 472478.10.1093/fampra/cmq048CrossRefGoogle ScholarPubMed
NCD Risk Factor Collaboration (NCD-RisC) (2017) Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19.1 million participants. Lancet 389, 3755.CrossRefGoogle Scholar
Earl, GL & Henstenburg, JA (2012) Dietary approaches to hypertension: a call to pharmacists to promote lifestyle changes. J Am Pharm Assoc 52, 637645.10.1331/JAPhA.2012.10241CrossRefGoogle Scholar
Proia, KK, Thota, AB, Njie, GJ et al. (2014) Team-based care and improved blood pressure control: a community guide systematic review. Am J Prev Med 47, 8699.10.1016/j.amepre.2014.03.004CrossRefGoogle ScholarPubMed
Santschi, V, Chiolero, A, Colosimo, AL et al. (2014) Improving blood pressure control through pharmacist interventions: a meta-analysis of randomized controlled trials. J Am Heart Assoc 3, e000718.10.1161/JAHA.113.000718CrossRefGoogle Scholar
Breda, J, Wickramasinghe, K, Peters, DH et al. (2019) One size does not fit all: implementation of interventions for non-communicable diseases. BMJ 367, l6434.CrossRefGoogle Scholar
Peters, DH, Peters, MA, Wickramasinghe, K et al. (2019) Asking the right question: implementation research to accelerate national non-communicable disease responses. BMJ 365, l1868.10.1136/bmj.l1868CrossRefGoogle ScholarPubMed
Andersson, P & Leppert, J (2001) Men of low socio-economic and educational level possess pronounced deficient knowledge about the risk factors related to coronary heart disease. J Cardiovasc Risk 8, 371377.CrossRefGoogle ScholarPubMed
Iaccarino Idelson, P, D’Elia, L, Cairella, G et al. (2020) Salt and health: survey on knowledge and salt intake related behaviour in Italy. Nutrients 12, 279.10.3390/nu12020279CrossRefGoogle ScholarPubMed
Millett, C, Laverty, AA, Stylianou, N et al. (2012) Impacts of a national strategy to reduce population salt intake in England: serial cross sectional study. PLoS ONE 7, e29836.10.1371/journal.pone.0029836CrossRefGoogle ScholarPubMed
Gee, ME, Bienek, A, Campbell, NR et al. (2012) Prevalence of, and barriers to, preventive lifestyle behaviors in hypertension (from a national survey of Canadians with hypertension). Am J Cardiol 109, 570575.10.1016/j.amjcard.2011.09.051CrossRefGoogle ScholarPubMed
Baharudin, A, Ambak, R, Othman, F et al. (2012) Knowledge, attitude and behaviour on salt intake and its association with hypertension in the Malaysian population: findings from MyCoSS (Malaysian Community Salt Survey). J Health Popul Nutr 40, 6.10.1186/s41043-021-00235-0CrossRefGoogle Scholar
Lynch, JW, Kaplan, GA & Salonen, JT (1997) Why do poor people behave poorly? Variation in adult health behaviours and psychosocial characteristics by stages of the socioeconomic lifecourse. Soc Sci Med 44, 809819.10.1016/S0277-9536(96)00191-8CrossRefGoogle ScholarPubMed
Ji, C & Cappuccio, FP (2014) Socioeconomic inequality in salt intake in Britain 10 years after a national salt reduction programme. BMJ Open 4, e005683.CrossRefGoogle ScholarPubMed
Cappuccio, FP, Ji, C, Donfrancesco, C et al. (2015) Geographic and socioeconomic variation of sodium and potassium intake in Italy: results from the MINISAL-GIRCSI programme. BMJ Open 5, e007467.10.1136/bmjopen-2014-007467CrossRefGoogle ScholarPubMed
D’Elia, L, Brajovic, M, Klisic, A et al. (2019) Sodium and potassium intake, knowledge attitudes and behaviour towards salt consumption amongst adults in Podgorica, Montenegro. Nutrients 11, 160.10.3390/nu11010160CrossRefGoogle ScholarPubMed
Webster, J, Santos, JA, Hogendorf, M et al. (2022) Implementing effective salt reduction programs and policies in low- and middle-income countries: learning from retrospective policy analysis in Argentina, Mongolia, South Africa and Vietnam. Public Health Nutr 25, 805816.CrossRefGoogle ScholarPubMed
World Health Organization & Regional Office for Europe (2018) Using Dietary Intake Modelling to Achieve Population Salt Reduction: A Guide to Developing a Country-Specific Salt Reduction Model. https://www.euro.who.int/__data/assets/pdf_file/0004/365242/salt-report-eng.pdf (accessed July 2022).Google Scholar
Magnusson, R & Patterson, D (2011) Role of law in global response to non-communicable diseases. Lancet 378, 859860.CrossRefGoogle Scholar
Gillespie, DO, Allen, K, Guzman-Castillo, M et al. (2015) The health equity and effectiveness of policy options to reduce dietary salt intake in England: policy forecast. PLoS ONE 10, e0127927.10.1371/journal.pone.0127927CrossRefGoogle ScholarPubMed
Cappuccio, FP, Capewell, S, Lincoln, P et al. (2011) Policy options to reduce population salt intake. BMJ 343, d4995.10.1136/bmj.d4995CrossRefGoogle ScholarPubMed
Figure 0

Table 1 Overview of WHO STEPS surveys in nine Eastern European and Central Asian countries

Figure 1

Table 2 Characteristics of study participants

Figure 2

Fig. 1 National prevalence of hypertension awareness, treatment and control according to education. Lower = less than high school. Medium = high school. Higher = college/university/postgraduate. *P-values derived from weighted multinomial mixed-effects regression models, adjusted for age, sex, marital status, weight status (normal weight, overweight and obese), and daily servings of vegetables and fruit

Figure 3

Table 3 Proportion of participants who received physician’s advice to reduce salt intake according to education and hypertension awareness, treatment and control status

Figure 4

Fig. 2 National prevalence of salt knowledge, perceptions of salt intake and salt consumption behaviours according to education. Lower = less than high school. Medium = high school. Higher = college/university/postgraduate. *P-values derived from weighted multinomial mixed-effects regression models, adjusted for age, sex, marital status, weight status (normal weight, overweight and obese), and daily servings of vegetables and fruit

Figure 5

Fig. 3 National prevalence of salt knowledge, perceptions of salt intake and salt consumption behaviours according to physician’s advice to reduce salt intake. Yes = received physician’s advice to reduce salt intake during the past 3 years. No = did not receive physician’s advice to reduce salt intake during the past 3 years. *P-values derived from weighted multinomial mixed-effects regression models, adjusted for age, sex, marital status, weight status (normal weight, overweight and obese), and daily servings of vegetables and fruit