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Biocompatibility and anticancer activity of L-phenyl alanine-coated iron oxide magnetic nanoparticles as potential chrysin delivery system

Published online by Cambridge University Press:  12 June 2018

Hamed Nosrati ,
Elham Javani ,
Marziyeh Salehiabar ,
Hamidreza Kheiri Manjili ,
Soodabeh Davaran  and
Hossein Danafar
Hamed Nosrati
Affiliation:
Student Research Center, Zanjan University of Medical Sciences, Zanjan 009824, Iran; and Department of Pharmaceutical Biomaterials, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan 009824, Iran
Elham Javani
Affiliation:
Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan 009824, Iran
Marziyeh Salehiabar
Affiliation:
Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan 009824, Iran
Hamidreza Kheiri Manjili
Affiliation:
Zanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan 009824, Iran
Soodabeh Davaran
Affiliation:
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 009841, Iran
Hossein Danafar*
Affiliation:
Department of Pharmaceutical Biomaterials, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan 009824, Iran; and Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan 009824, Iran
*
a)Address all correspondence to this author. e-mail: [email protected]
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Abstract

In this project, we described the production of chrysin-loaded L-phenyl alanine (Phe)-coated iron oxide magnetic nanoparticles (chrysin@Phe@IOMNs). chrysin@Phe@IOMNs were characterized by X-ray diffraction, thermogravimetric analysis, fourier transform infrared spectroscopy, vibrating sample magnetometer, and transmission electron microscopy techniques. Next, hemocompatibility and biocompatibility of Phe-coated IOMNs were determined by hemolysis and MTT assays on HFF-2 and HEK-293 cell lines, respectively. Finally, the anticancer activity of chrysin@Phe@IOMNs was examined on MCF-7 cell line. The outcomes direct that as-prepared nanocarriers are nontoxic and biocompatible and also chrysin@Phe@IOMNs are appropriate for chrysin delivery and other hydrophobic therapeutic agents.

Keywords

magnetic nanoparticlesbiomaterialferromagnetichemolysisdrug deliverychrysinnanostructure
Type
Article
Information
Journal of Materials Research , Volume 33 , Issue 11 , 13 June 2018 , pp. 1602 - 1611
Copyright
Copyright © Materials Research Society 2018 

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