Potential determinants of continued low weight status after weight loss

It is known that important changes in eating behaviours can differ between short- and long-term weight changes⁽ Reference Jabs and Devine ^{10 )}. Reyes et al.⁽ Reference Reyes, Oliver and Klotz ^{11 )} documented the existing similarities and differences between weight loss in regainers (those who had regained ≥33 % of their weight loss as compared with the end of intervention) and subsequent maintainers (those who had sustained their initial weight loss for at least 1 year and regained ≤15 % as compared with the end of intervention; Table 1). They identified only three determinants of low weight status after using a slimming diet: self-monitoring of dietary intake over time, large support during the weight regain phase, and using small size clothing. Furthermore, they reported the main determinants connected with unsuccessful maintenance of low weight status: worse adaptation to changes in the lifestyle to continue diet and PA, using less positive self-talk and loss of effectiveness in problem-solving techniques during the weight regain phase. Researchers⁽ Reference Byrne, Cooper and Fairburn ^{3 )} have speculated on some additional explanations why obese subjects gain weight after successful weight loss. The main factors according to Byrne et al.⁽ Reference Byrne, Cooper and Fairburn ^{3 )} were: failure to achieve weight goals and dissatisfaction with the weight achieved, a tendency to evaluate self-worthiness in terms of weight and shape, lack of vigilance in weight control and a dichotomous (black-and-white) thinking style. Regainers also did not permit themselves to any of the food they really enjoyed and therefore felt deprived⁽ Reference Kayman, Bruvold and Stern ^{12 )}. Moreover, stress during the weight regain phase seems to be an important factor for weight change, also demonstrating it to be a critical factor for inducing overeating⁽ Reference Manzoni, Pagnini and Gorini ^{13 )}. The study of Sarlio-Lähteenkorva et al.⁽ Reference Sarlio-Lähteenkorva, Rissanen and Kaprio ^{14 )} carried out in men with 6 and 15 years follow-up documented the failure to maintain weight loss as a result of a stressful life and high alcohol intake.

Table 1. The potential determinants of weight status after using slimming diet in obese subjects⁽ Reference Reyes, Oliver and Klotz ^{11 )}

One of the most important aspects influencing the motivation towards a long-term weight regain is also the low initial weight loss⁽ Reference Kaholokula, Townsend and Sinclair ^{15 )}. The retrospective analyses of pooled data from two multicentric, randomised, placebo-controlled clinical trials were in line with this statement. Weight loss of >5 % body weight after 12 weeks diet and Orlistat were a good indicator of 2-year weight loss, whereas ≥2·5 kg initial weight loss during the 4-week run-in phase and ≥10 % weight loss after 6 months did not add significantly to the prediction of the 2-year outcome⁽ Reference Rissanen, Lean and Rössner ^{16 )}. In weight regainers, it has also been shown that self-monitoring of food intake and weight control decline over time⁽ Reference Byrne, Cooper and Fairburn ^{3 )}. According to Teixeira et al.⁽ Reference Teixeira, Silva and Coutinho ^{17 )} lowering emotional eating and adopting a flexible dietary restraint pattern are critical factors for sustained low weight status. Therefore, for long-term success, interventions must also be effective in promoting exercise, intrinsic motivation and self-efficacy. Self-efficacy can be improved during the study conduct; however, in regainers it was connected with low intrinsic motivation leading to easily giving up⁽ Reference Johnston, Tyler and Foreyt ^{18 )}. In the study by Dennis and Golberg⁽ Reference Dennis and Goldberg ^{19 )} the type of disbelievers berating themselves for their perceived aberrant behaviour intensified their already hesitant self-efficacy beliefs. The disbelieving women did not believe they had the inner strength or self-control to do what needed to be done to manage their weight successfully. Additionally, they reflected doubt, self-recrimination, and marked dependency needs in weight control.

Some studies could show that weight regain is more pronounced when food choice is unrestricted and high in fat content⁽ Reference Cotton, Burley and Weststrate ^{20 ,} Reference Swinburn, Caterson and Seidell ^{21 )}. However, a high fat content of the diet might prevent food craving which has been also identified as factor favouring weight regain⁽ Reference Massey and Hill ^{22 )}. As shown by Anton et al.⁽ Reference Anton, Gallagher and Carey ^{23 )} a high-fat diet (40 % energy from fat) reduced cravings for carbohydrates at month 12 (P<0·05) and fruit and vegetables at month 24. Additionally, participants reported significant reductions in food cravings for specific types of foods (i.e. high-fat foods, fast food, fats; P<0·05). Conversely, Martin et al.⁽ Reference Martin, Rosenbaum and Han ^{24 )} showed that compared with the low carbohydrate diet, the low-fat diet induced significantly larger decreases in cravings for high-fat foods. No evidence was found to support the belief that restricting intake of certain foods could lead to increased craving for these foods⁽ Reference Harvey, Wing and Mullen ^{25 )}. The future challenge would be to develop a strategy that diminishes craving for high energy sweets and fast food. The study of Batra et al. ⁽ Reference Batra, Das and Salinardi ^{26 )} suggested that a better strategy than the reduction in craving could be a reduction in hunger. Thomas et al.⁽ Reference Thomas, Bechtell and Vestal ^{27 )} hypothesised that subjective hunger and desire for food can change significantly, after 1d  over- or underfeeding. Currently, it seems impossible to assess the effectiveness of hunger-suppressing v. craving-suppressing strategies for obesity therapy.

Sleep in weight regulation

A number of studies have suggested that there is a link between sleep loss and weight gain in adults⁽ Reference Weiss, Xu and Storfer-Isser ^{28 )}. Physiological studies have shown that sleep deprivation may influence weight through effects on appetite, PA and/or thermoregulation⁽ Reference Piaggi, Krakoff and Bogardus ^{29 )}. Experimental reductions in sleep duration support the claim that sleeping time could alter metabolic rates or affect the levels of appetite regulatory hormones such as leptin and ghrelin⁽ Reference St-Onge, O'Keeffe and Roberts ^{30 )}. An association between insufficient sleep and increased energy intake has been demonstrated in some studies⁽ Reference Piaggi, Krakoff and Bogardus ^{29 –} Reference Labayen, Ortega and Ruiz ^{31 )}.

Sleep restriction was associated with an increase in energy consumption with no change in energy expenditure through PA or leptin and ghrelin concentrations⁽ Reference Calvin, Carter and Adachi ^{32 )}. As shown by Nedeltchova et al.⁽ Reference Nedeltcheva, Kilkus and Imperial ^{33 )}, bedtime restriction promotes overeating and low activity which was accompanied by increased intake of energy from snacks with higher carbohydrate content without a statistically significant change in the consumption of energy from meals. Markwald et al.⁽ Reference Markwald, Melanson and Smith ^{34 )} found that insufficient sleep increased not only total daily energy expenditure by ~5 %, but also energy intake, especially at night after having finalised the dinner. The increase in energy intake was exceeding the energy needed to maintain the energy balance. The insufficient sleep was leading to 0·82 (sd 0·47) kg weight gain. Recent studies found evidence⁽ Reference Greer, Goldstein and Walker ^{35 )} that sleep deprivation significantly decreases activity in appetitive evaluation regions, within the human frontal cortex and insular cortex during food desirability choices, combined with a converse amplification of activity within the amygdala. Another question that is encountered in the clinical setting is whether this bi-directional change in the profile of brain activity is further associated with a significant increase in the desire for weight-gain promoting high-energy foods⁽ Reference Greer, Goldstein and Walker ^{35 )}. These findings suggest a role for improving sleep duration as a component of weight management strategy⁽ Reference Greer, Goldstein and Walker ^{35 )}.

Effectiveness of energy restriction and macronutrient composition of the diet on regain

The detailed results of intervention studies investigating weight regain identified from the systematic literature search and selected for this review are shown in Table 2. The number of participants in each study was at least 110 and the baseline average BMI in the studied subjects was higher than 35 kg/m². Champagne et al.⁽ Reference Champagne, Broyles and Moran ^{39 )}, Kuller et al.⁽ Reference Kuller, Pettee and Kinzel ^{40 )} and Svetkey et al.⁽ Reference Svetkey, Stevens and Brantley ^{43 )} included also overweight participants. In the weight loss period, all authors⁽ Reference Bischoff, Damms-Machado and Betz ^{36 –} Reference Svetkey, Stevens and Brantley ^{43 )} applied the reduction of energy intake to at least 5020·8–7531·2 kJ/d⁽ Reference Wadden, Neiberg and Wing ^{37 –} Reference Kuller, Pettee and Kinzel ^{40 ,} Reference Lindström, Louheranta and Mannelin ^{42 ,} Reference Svetkey, Stevens and Brantley ^{43 )} even to very low energy diet⁽ Reference Lantz, Peltonen and Agren ^{41 )} and with ready-to-use formula (Optifast)⁽ Reference Bischoff, Damms-Machado and Betz ^{36 )}. The content of fat in the diet was taken into account especially by Wadden et al.⁽ Reference Wadden, Neiberg and Wing ^{37 )}, Milson et al.⁽ Reference Milsom, Middleton and Perri ^{38 )}, Kuller et al.⁽ Reference Kuller, Pettee and Kinzel ^{40 )} and Svetkey et al.⁽ Reference Svetkey, Stevens and Brantley ^{43 ).} In these studies, consumption under 30 % of energy from fat intake was generally taken as goal for the participants. In all studies included in this review article, increase in PA (goal about 180 min/week) was one of the intervention measures, with the exception of the studies performed by Kuller et al.⁽ Reference Kuller, Pettee and Kinzel ^{40 )} and Lantz et al.⁽ Reference Lantz, Peltonen and Agren ^{41 )}. Each study conducted the education and dietary counselling for participants as individual as well as group sessions and provided this counselling in different forms, mostly face-to-face but also via email or telephone. Phases of meal replacements were applied in the studies performed by Bischoff et al.⁽ Reference Bischoff, Damms-Machado and Betz ^{36 )} and Wadden et al.⁽ Reference Wadden, Neiberg and Wing ^{37 )}. The measurements of weight gain during follow-up were different across the studies and included direct weight measurements, self-reports of attained weight and assessment of biomarker concentrations. Furthermore, in some studies data on determinants of weight management were also collected. Milsom et al.⁽ Reference Milsom, Middleton and Perri ^{38 )}, for example, added a weight management questionnaire to the assessment of weight development after 3·5 years follow-up. The questionnaire results showed that unsuccessful participants were less engaged in record keeping, in regular self-weighing, in planned meals ahead of time and in goal setting subscales, e.g. energy, fruit and vegetables, fat. After 3 years, Wadden et al.⁽ Reference Wadden, Neiberg and Wing ^{37 )} presented in addition to the results on weight changes also data on self-reported energy intake and energy expenditure (Paffenberger Activity Questionnaire). In this study, the oldest participants (65–76 years) reported lower daily energy intake than younger individuals and men significantly higher weekly energy expenditure from PA and higher energy intake than women. At year 4, intensive lifestyle intervention (ILI) participants achieved a mean loss of 4·7 (se 0·2) % of initial weight, compared with 1·1 (se 0·2) % for individuals in diabetes support and education (P<0·0001). Also Svetkey et al.⁽ Reference Svetkey, Stevens and Brantley ^{43 )} provided similar data in addition to weight change. Lantz et al.⁽ Reference Lantz, Peltonen and Agren ^{41 )} and Bischoff et al.⁽ Reference Bischoff, Damms-Machado and Betz ^{36 )}, showed only the changes in body weight and BMI after 2-years observation. Champagne et al.⁽ Reference Champagne, Broyles and Moran ^{39 )} presented additionally the changes related to diet by the application of a FFQ. Significant increases from baseline to 6 months were seen in per cent energy from carbohydrate (8·4 (se 0·3) %) and protein (0·9 (se 0·1) %), daily dairy servings (0·4 (se 0·03)) and daily fruit and vegetable servings (3·5 (se 0·1)). Other studies⁽ Reference Kuller, Pettee and Kinzel ^{40 ,} Reference Lindström, Louheranta and Mannelin ^{42 )} also included the changes in biomarker concentrations (e.g. LDL-cholesterol, HDL-cholesterol, glucose and insulin). In Lindstroem's study⁽ Reference Lindström, Louheranta and Mannelin ^{42 )} significant improvements were seen at year 1 in fasting plasma glucose (0·2 v. 0·0 mmol/l), 2-h plasma glucose (0·9 v. 0·3 mmol/l), HbA1c (0·1 v. 0·1 %), serum total cholesterol to HDL-cholesterol ratio (0·4 v. 0·1), and serum TAG (0·2 v. 0·0 mmol/l) in the intervention group compared with the control group. Additionally, Kuller et al.⁽ Reference Kuller, Pettee and Kinzel ^{40 )} found that systolic blood pressure (P = 0·048), LDL-cholesterol (P = 0·026), TAG (P = 0·92), insulin (P = 0·0001), glucose (P = 0·002) and HDL-cholesterol (P = 0·0001) developed significantly differently between the Health Education and the Lifestyle Change group. In the reviewed studies, the weight changes from baseline to weight loss ranged from −4·0 to −0·2 kg; in two studies they were not reported⁽ Reference Milsom, Middleton and Perri ^{38 ,} Reference Lantz, Peltonen and Agren ^{41 )}. However, the studies with no data on weight loss reported an average weight regain of about 4 kg⁽ Reference Bischoff, Damms-Machado and Betz ^{36 –} Reference Milsom, Middleton and Perri ^{38 )} and percentage changes in body weight between 4 and 15·1 %⁽ Reference Bischoff, Damms-Machado and Betz ^{36 –} Reference Milsom, Middleton and Perri ^{38 )}. The participants were often re-contacted several times during follow-up, e.g. via emails containing newsletters with information related to weight management.

Table 2. Long-term weight status after energy restriction and changes in macronutrient composition of the diet

N/R, not reported; PA, physical activity; ITT, intention to treat; WC, waist circumference; ILI, intensive lifestyle intervention; SBP, systolic blood pressure; HbA1c, glycated haemoglobin; TC, total cholesterol; LDL-C, low-density lipoprotein; HDL-C, high-density lipoprotein; Glc, glucose; NMR HDL-P, NMR LDL-P, NMR small LDL-P – proton NMR spectroscopy method for quantifying plasma lipoproteins.

In the first phase (weight reduction period), the effectiveness of different strategies for weight reduction in obese subjects has been investigated⁽ Reference Bischoff, Damms-Machado and Betz ^{36 –} Reference Svetkey, Stevens and Brantley ^{43 )}. It has been shown that similar responses regarding satiety, hunger and satisfaction exist for diets with different proportion of nutrients⁽ Reference Sacks, Bray and Carey ^{44 )}. In general, the reduced-energy diets result in clinically meaningful weight losses regardless of which macronutrients they emphasise⁽ Reference Bischoff, Damms-Machado and Betz ^{36 –} Reference Sacks, Bray and Carey ^{44 )}. For long-term weight loss, macronutrient composition should also be considered regarding whether it helps to counteract compensatory mechanisms leading to weight regain after weight loss⁽ Reference Jakubowicz, Froy and Wainstein ^{45 )}. Thus, interest has been rising for a comparison of different low energy diets containing different ratios of fat, protein and carbohydrates in relation to long-term weight gain. Particular interest was recently given to protein⁽ Reference Bischoff, Damms-Machado and Betz ^{36 ,} Reference Wadden, Neiberg and Wing ^{37 )} and fat⁽ Reference Milsom, Middleton and Perri ^{38 –} Reference Kuller, Pettee and Kinzel ^{40 ,} Reference Svetkey, Stevens and Brantley ^{43 )}. It was found by one group that a high carbohydrate and protein breakfast is preventing weight regain by reducing diet-induced compensatory changes in hunger, cravings and ghrelin suppression⁽ Reference Jakubowicz, Froy and Wainstein ^{45 )}. High-protein diets may also be related to higher levels of thermogenesis, which can increase energy efficiency during weight loss and help avoiding weight regain⁽ Reference Lejeune, Kovacs and Westerterp-Plantenga ^{46 )}. It was shown by one study that body-weight loss and low weight-gain depend on the high-protein content of the diet, rather than the low-carbohydrate component, while it is unrelated to the concomitant fat-content of the diet⁽ Reference Sørensen, Boutin and Taylor ^{47 )}. Furthermore, the Mediterranean and Dietary Approaches to Stop Hypertension diet, which was recommended by Champagne et al.⁽ Reference Martin, Rosenbaum and Han ^{48 )} and Svetkey et al.⁽ Reference Svetkey, Stevens and Brantley ^{43 )} for the weight reduction phase, encourages intakes of fruit, vegetables, nuts, and whole grains and discourages intakes of red and processed meats and saturated fat. Unlike the Mediterranean diet, the Dietary Approaches to Stop Hypertension diet, in addition, discourages sodium and sugar-sweetened beverages and encourages the intake of low-fat dairy, and has no specific alcohol recommendation⁽ Reference Connors, Bisogni and Sobal ^{8 )}. Indeed, the Dietary Approaches to Stop Hypertension diet was related to a reduction in body weight in a high cardiovascular risk population and also prevented weight gain⁽ Reference Hunter, Brock and Byrne ^{49 ,} Reference Berz, Singer and Guo ^{50 )}.

Taking into consideration the age of the participants, as it was expected, younger participants were more familiar with web-based methods and in their case, implementation of web-based methods was a highly effective strategy than older participants, who prefer the traditional methods for information distribution (e.g. newsletter or telephone conferences) and also a manually and simplified form of contact with nutritionist⁽ Reference Neve, Morgan and Collins ^{6 ,} Reference Milsom, Middleton and Perri ^{38 ,} Reference Svetkey, Stevens and Brantley ^{43 , 51 –} Reference Hebden, Balestracci and McGeechan ^{53 )}. In both cases, the face-to-face counselling condition obtained the best results⁽ Reference Bischoff, Damms-Machado and Betz ^{36 ,} Reference Wadden, Neiberg and Wing ^{37 ,} Reference Champagne, Broyles and Moran ^{39 –} Reference Lindström, Louheranta and Mannelin ^{42 )}. This condition also allowed the study subjects to cope with the new dietary approach in a very short time period. Moreover, the research study should give each of the study participants the opportunity to participate in further behavioural and dietary counselling beyond the scientific study. A key message from the study review is that to build good relations between study subjects and nutritionist, the dietary counselling should be conducted by the same team throughout the study period⁽ Reference Bischoff, Damms-Machado and Betz ^{36 –} Reference Svetkey, Stevens and Brantley ^{43 )}. As mentioned previously, clinicians need to emphasise the role of healthy diet for healthy lifestyle.

In the second phase (weight regain phase), the key point seems to be the self-regulation of dietary intake which stays in close connection with changes in dietary habits. It was found in general that individuals who had used a self-guided approach maintained their initial weight loss with great success, even better than those individuals who had used a very low energy diet⁽ Reference Bischoff, Damms-Machado and Betz ^{36 ,} Reference Lindström, Louheranta and Mannelin ^{42 )}. The involvement of study participants in the process of preparing healthy meals might be an important step for obese people, especially in the case when they are losing the motivation to stay slim⁽ Reference Sabinsky, Toft and Raben ^{54 )}. The study conducted by ter Bogt et al.⁽ Reference ter Bogt, Bemelmans and Beltman ^{55 )} did not indicate differences in preventing weight gain between structured lifestyle counselling by nurse practitioners compared with usual care by general practitioners in overweight and obese subjects. For the future, it seems to be important not only to record the mean value of weight loss after the intervention period but also focusing on the long-term body weight gain including a more comprehensive documentation of the data during follow-up. In view of the role of dietary changes and their determinants, the documented long-term data on changes in body weight in the studies had been unsatisfactory, particularly in regard to changes in the self-estimation by the study participants⁽ Reference Wadden, Neiberg and Wing ^{37 ,} Reference Milsom, Middleton and Perri ^{38 )}. The available evidence from clinical trials suggests that obese subjects used to perceive themselves as less obese and have a tendency to declare less food intake than actually eaten⁽ Reference Quick, Nansel and Liu ^{56 )}.

Physical activity and weight regain

The selected studies which integrate the PA into the changes of lifestyle are presented in Table 3. The majority of the studies focused on obese subjects, with the exception of Hunter et al.⁽ Reference Hunter, Brock and Byrne ^{49 )} and Nakade et al.⁽ Reference Nakade, Aiba and Suda ^{57 )} who included both obese and overweight subjects. The studies were different in PA by demographic characteristics. Participants younger than 50 years, male, non-African American or overweight are more active than those who are older than 50 years, female, African American or obese⁽ Reference Young, Jerome and Chen ^{60 )}. Moreover, only 2 % of participants are active for 60 or more minutes daily. It should be underlined that sex differences between energy expenditure related to PA, appetite ratings and energy intake may lead to different patterns of energy intake and subsequent weight maintenance⁽ Reference Harrington, Martin and Ravussin ^{61 )}.

Table 3. Physical activity in long-term weight status

CG, control group; HPA, high physical activity; N/R, not reported; SBT, standard behaviour therapy; WC, waist circumference; VLED, very-low-energy diet.

Very few reviewed intervention studies have explored whether the programmes based on diet and exercise gave better results regarding anthropometry than the use of one method alone⁽ Reference Hunter, Brock and Byrne ^{49 ,} Reference Nakade, Aiba and Suda ^{57 –} Reference Jeffery, Wing and Sherwood ^{59 )}. Often the PA is much more difficult to perform by obese subjects, because performance is related to public places. Public places are perceived negatively by this group of subjects, and they are spending ‘extra’-money or finding ‘extra’ time for exercises⁽ Reference Hagberg and Lindholm ^{62 )}. In sedentary and obese subjects, it was also found that a supervised exercise-based programme appears to be more efficacious in promoting and maintaining weight loss and improvements in markers of health and fitness compared with an individual counselling and group sessions focused on exercises⁽ Reference Nakade, Aiba and Suda ^{57 ,} Reference Borg, Kukkonen-Harjula and Fogelholm ^{58 )}. It was also observed that both aerobic and resistance training prevented regain of potentially harmful visceral fat⁽ Reference Hunter, Brock and Byrne ^{49 )}. Most likely daily self-monitoring of PA can be one of the feasible and effective approaches for low long-term weight regain. Even 12-months of small-changes of PA due to intervention can be successful in sustaining initial weight loss⁽ Reference Zinn, Schofield and Hopkins ^{63 )}. Thus, the literature clearly indicates that increased PA is one of the main predictors of low weight status after weight reduction⁽ Reference Phelan, Wing and Loria ^{64 )}. Increasing PA with increased weight loss might help to maintain weight loss itself⁽ Reference Bonini, Fioretti and Sargentini ^{65 )}. It should be noted that often even moderate weight losses, induced by energy restriction, lead to a large decrease in PA. However, the decrease in PA returns to baseline levels when weight loss is maintained⁽ Reference Ebbeling, Swain and Feldman ^{66 )}. Thus, clinicians should remind all patients that without maintenance of an active lifestyle, the risk of weight regain is highly increased. The American College of Sports Medicine recommends 150–250 min/week PA to prevent weight gain which should be increased up to 200–300 min/week for prevention of weight gain after weight loss⁽ Reference Donnelly, Blair and Jakicic ^{67 )}.

Similarly, as in Table 2, in the studies with intervention of PA, only the basic anthropometrical measurements and the energy expenditure during follow-up were assessed, based upon self-administered questionnaires⁽ Reference Nakade, Aiba and Suda ^{57 –} Reference Jeffery, Wing and Sherwood ^{59 )}. An implementation of easy to use tools, e.g. accelerometers can be an appropriate mean to favour the maintenance of PA in obese or older adults⁽ Reference Bélanger-Gravel, Godin and Bilodeau ^{68 )}. In the studies, an intensive lifestyle intervention including high volume of PA resulted in favourable changes in CVD risk factors and eating behaviours in subjects with severe obesity⁽ Reference Danielsen, Svendsen and Mæhlum ^{69 )}. The lifestyle counselling by either nurses or general practitioners obtained similar results after 3 years intervention in terms of higher PA and healthier diet⁽ Reference Driehuis, Barte and Ter Bogt ^{70 )}. Although the studies used different study designs, diet programme and exercise duration, even with a shorter term follow-up, all measures of an increase of PA can be recommended due to its evident beneficial effect on health status.

Conclusions and challenges

In the strategy of successful long-term weight loss among the obese the main role should be given to a diet with self-regulation of dietary intake. This measure should be combined with behaviour therapy and PA and tailored to the individual situation. In addition, the psychosocial condition of the obese subjects stays in close relation to their motivation. However, after having analysed the papers, it is difficult to arrive at a conclusion regarding unambiguous measures related to low long-term weight regain in obese subjects and to recommend a specific dietary intervention.

From the present literature, it appears that more standardised measurements of determinants of weight changes and low weight regain will provide more comparable data and will allow for a better interpretation of the study results. The challenges are seen to harmonise and standardise the data collected in the follow-up period of long-term weight loss studies. The standardised format of data collected in different countries with different languages could give an opportunity for more extensive analysis of existing datasets. Moreover, it appears useful to build up easily accessible programmes for obese subjects after weigh loss by an interdisciplinary team that would include nutritional education, individual well-balanced diet, promotion of PA and measures to keep a high motivation of behavioural changes. Regular use of interactive web-sites and potential contact with nutritionist could bring an additional benefit for participants in the follow-up period. Therefore in the process of development of such programmes for obese subjects, all details of the studies conducted so far could be important and should be considered.